Patents by Inventor Sallie Permar

Sallie Permar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ZIKA ANTIBODIES AND THEIR USE
    Publication number: 20220315646
    Abstract: The invention is directed to antibodies, and antigen-binding fragments thereof, that potently neutralize infection of ZIKV. The invention also relates to antigenic sites to which the antibodies and antigen-binding fragments bind, as well as to nucleic acids that encode the antibodies of the invention, and immortalized B cells that produce such antibodies and antibody fragments. In addition, the invention relates to the use of the antibodies and antibody fragments of the invention in screening methods as well as in the diagnosis, prophylaxis and treatment of ZIKV infection.
    Type: Application
    Filed: September 11, 2020
    Publication date: October 6, 2022
    Inventors: Sallie PERMAR, Mattia BONSIGNORI, Tulika SINGH, Kwan-Ki HWANG
  • COMPOSITIONS COMPRISING SUPRAMOLECULAR NANOFIBER HIV ENVELOPES AND METHODS FOR THEIR USE
    Publication number: 20220040290
    Abstract: The technology provides immunogenic compositions comprising HIV-1 envelopes in supramolecular nanofiber complexes, which may also comprise a T-cell helper epitopes, and methods of using these compositions for induction of immune responses.
    Type: Application
    Filed: September 24, 2019
    Publication date: February 10, 2022
    Inventors: Sallie PERMAR, Joel COLLIER, Kevin O. SAUNDERS, Chelsea FRIES, Fouda Amou'ou Genevieve GINY
  • MULTIVALENT CMV VACCINE AND USES THEREOF
    Publication number: 20210260184
    Abstract: The invention is directed to multivalent HCMV immunogenic compositions and their use.
    Type: Application
    Filed: July 19, 2019
    Publication date: August 26, 2021
    Inventors: Sallie PERMAR, Cody NELSON, Jennifer JENKS
  • Methods for reducing HIV-1 mother-to-child transmission by inducing V3-specific or CD4 binding site-specific antibodies
    Patent number: 11077130
    Abstract: The invention provides compositions and methods to induce and boost antibody response, including but not limited to IgG responses binding to HIV-1 in a subject in need thereof, wherein the induced/boosted plasma level of the antibody responses, for example V3 and/or CD4 binding site antibody responses, is over a threshold level and is associated with reduced risk of maternal-to-child-transmission (MTCT) of HIV-1.
    Type: Grant
    Filed: September 26, 2014
    Date of Patent: August 3, 2021
    Assignee: DUKE UNIVERSITY
    Inventors: Barton F. Haynes, Sallie Permar, M. Anthony Moody, Feng Gao, Hua-Xin Liao, Georgia Tomaras, David C. Montefiori
  • HIV-1 MOTHER-TO-CHILD TRANSMISSION CORRELATES OF PROTECTION AND VACCINE
    Publication number: 20160339051
    Abstract: The invention provides compositions and methods to induce and boost antibody response, including but not limited to IgG responses binding to HIV-1 in a subject in need thereof, wherein the induced/boosted plasma level of the antibody responses, for example V3 and/or CD4 binding site antibody responses, is over a threshold level and is associated with reduced risk of maternal-to-child-transmission (MTCT) of HIV-1.
    Type: Application
    Filed: September 26, 2014
    Publication date: November 24, 2016
    Inventors: Barton F. Haynes, Sallie Permar, M. Anthony Moody, Feng Gao, Hua-Xin Liao, Georgia Tomaras, David C. Montefiori