Patents by Inventor Sally E. Spence

Sally E. Spence has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Targeted recombinant viral vectors
    Publication number: 20030175973
    Abstract: The present invention provides methods and a composition for targeted delivery of a nucleic acid to a cell comprising a biotinylated recombinant encapsidated virus, particularly adenovirus, wherein the recombinant adenovirus comprises the nucleic acid, and wherein the biotinylated recombinant virus is linked via streptavidin to a biotinylated targeting moiety.
    Type: Application
    Filed: March 20, 2003
    Publication date: September 18, 2003
    Inventors: Sally E. Spence, Jeffrey S. Smith, Jonathan R. Keller
  • Gene transfer in poultry by introduction of embryo cells in ovo
    Publication number: 20030150006
    Abstract: A method of altering the phenotype of a bird comprises introducing a DNA sequence into somatic cells of a bird contained within an egg during in ovo incubation. The DNA sequence is selected to be effective to cause a change in phenotype, such as an increase in growth rate, feed efficiency, or both in the bird after hatch. A DNA sequence may further be selected to increase disease resistance or induce disease prevention by the expression of an antigen over a period of time.
    Type: Application
    Filed: January 31, 2003
    Publication date: August 7, 2003
    Inventors: James Petitte, Catherine A. Ricks, Sally E. Spence
  • Complex of biotinylated viral vector and ligand for targeted gene delivery
    Patent number: 6555367
    Abstract: The present invention provides a composition for targeted delivery of a nucleic acid to a cell comprising a biotinylated recombinant adenovirus, wherein biotin is covalently linked to the recombinant adenovirus, wherein the recombinant adenovirus comprises the nucleic acid, and wherein the recombinant adenovirus is linked via streptavidin to a biotinylated targeting moiety. Also provided by this invention is a method for targeted delivery of a nucleic acid to a selected cell in a subject comprising administering to the subject a composition comprising a biotinylated recombinant adenovirus, wherein biotin is covalently linked to the recombinant adenovirus, wherein the recombinant adenovirus comprises the nucleic acid, and wherein the recombinant virus is linked via streptavidin to a biotinylated targeting moiety that specifically targets the selected cell.
    Type: Grant
    Filed: June 15, 2000
    Date of Patent: April 29, 2003
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Sally E. Spence, Jeffrey S. Smith, Jonathan R. Keller
  • Gene transfer in poultry by introduction of embryo cells in ovo
    Patent number: 6515199
    Abstract: A method of altering the phenotype of a bird comprises introducing a DNA sequence into somatic cells of a bird contained within an egg during in ovo incubation. The DNA sequence is selected to be effective to cause a change in phenotype, such as an increase in growth rate, feed efficiency, or both in the bird after hatch. A DNA sequence may further be selected to increase disease resistance or induce disease prevention by the expression of an antigen over a period of time.
    Type: Grant
    Filed: May 19, 1995
    Date of Patent: February 4, 2003
    Assignee: North Carolina State University
    Inventors: James Petitte, Catherine A. Ricks, Sally E. Spence