Abstract: The present invention provides a board game for use as a didactic teaching-aid for individuals that are interested in the immune system. The game comprises a playing board having a continuous main course having a plurality of playing spaces. Each playing space contains a number that matches the number of an immune scenario vignette that constitutes an exposure to an infectious disease or to an immune disease state, such as an auto-immune disease or an immune-deficiency. A method of curing or treating the disease, and information about the disease is provided in a disease handout that the players reference while tending to their disease at a hospital, clinic or pharmacy, depending on the nature of the exposure. When a player attains immunity, they become immune to those diseases that are subsequently encountered.