Abstract: Disclosed herein are methods, kits, and systems for detecting or determining an amount, quantity, concentration and/or level of immunoglobulin G, subclass 4 (LgG4) in a biological sample from a subject. Particularly, the methods, kits and systems are directed to detection of IgG4 using an anti-IgG4 antibody that does not cross-react with other IgG subclasses.

Abstract: Device independent access to stored caller data during an emergency communications event. A call server intercepts an emergency call and determines the capabilities of a calling device. Based on calling device capability, the call server uses one or more of the following device independent methods to ascertain a caller identity, independent of a calling device: interactive voice response redirect, HTTP authentication, SIP INFO method, biometric recognition, human interaction, and alternate number dialing. A caller identity is then used to query a subscriber database for a unique caller profile database key (CPDBK) assigned to the caller (unless a CPDBK is already determined). A call server uses a CPDBK to query a caller profile database (CPDB) for relevant caller data. Relevant caller data and the intercepted emergency communications event are then passed to an emergency call processing system, whereby relevant caller data may be used to more effectively address an emergency situation.

Abstract: A prank call server that performs 911 prank call filtering over a 911 emergency call system, prior to routing a 911 call to a PSAP. The inventive prank call server identifies prank calling devices, regardless of current service subscription, by retrieving and analyzing emergency call data pertaining to detected prank 911 calls. The prank call server assigns a unique global identifier to each 911 call detected on the 911 emergency call system. Unique global identifiers enable a PSAP to uniquely identify prank 911 calls that are identified thereon. A PSAP transmits a prank call signal and a relevant unique global identifier to the prank call server, for each prank 911 call that is detected. A prank call signal/unique global identifier combination triggers the prank call server to store all available call data for a referenced prank 911 call in to a prank call database, for subsequent prank call filtering analysis.

Abstract: A prank call server that performs 911 prank call filtering over a 911 emergency call system, prior to routing a 911 call to a PSAP. The inventive prank call server identifies prank calling devices, regardless of current service subscription, by retrieving and analyzing emergency call data pertaining to detected prank 911 calls. The prank call server assigns a unique global identifier to each 911 call detected on the 911 emergency call system. Unique global identifiers enable a PSAP to uniquely identify prank 911 calls that are identified thereon. A PSAP transmits a prank call signal and a relevant unique global identifier to the prank call server, for each prank 911 call that is detected. A prank call signal/unique global identifier combination triggers the prank call server to store all available call data for a referenced prank 911 call in to a prank call database, for subsequent prank call filtering analysis.

Abstract: Device independent access to stored caller data during an emergency communications event. A call server intercepts an emergency call and determines the capabilities of a calling device. Based on calling device capability, the call server uses one or more of the following device independent methods to ascertain a caller identity, independent of a calling device: interactive voice response redirect, HTTP authentication, SIP INFO method, biometric recognition, human interaction, and alternate number dialing. A caller identity is then used to query a subscriber database for a unique caller profile database key (CPDBK) assigned to the caller (unless a CPDBK is already determined). A call server uses a CPDBK to query a caller profile database (CPDB) for relevant caller data. Relevant caller data and the intercepted emergency communications event are then passed to an emergency call processing system, whereby relevant caller data may be used to more effectively address an emergency situation.

Abstract: Device independent access to stored caller data during an emergency communications event. A call server intercepts an emergency call and determines the capabilities of a calling device. Based on calling device capability, the call server uses one or more of the following device independent methods to ascertain a caller identity, independent of a calling device: interactive voice response redirect, HTTP authentication, SIP INFO method, biometric recognition, human interaction, and alternate number dialing. A caller identity is then used to query a subscriber database for a unique caller profile database key (CPDBK) assigned to the caller (unless a CPDBK is already determined). A call server uses a CPDBK to query a caller profile database (CPDB) for relevant caller data. Relevant caller data and the intercepted emergency communications event are then passed to an emergency call processing system, whereby relevant caller data may be used to more effectively address an emergency situation.

Abstract: A prank call server that performs 911 prank call filtering over a 911 emergency call system, prior to routing a 911 call to a PSAP. The inventive prank call server identifies prank calling devices, regardless of current service subscription, by retrieving and analyzing emergency call data pertaining to detected prank 911 calls. The prank call server assigns a unique global identifier to each 911 call detected on the 911 emergency call system. Unique global identifiers enable a PSAP to uniquely identify prank 911 calls that are identified thereon. A PSAP transmits a prank call signal and a relevant unique global identifier to the prank call server, for each prank 911 call that is detected. A prank call signal/unique global identifier combination triggers the prank call server to store all available call data for a referenced prank 911 call in to a prank call database, for subsequent prank call filtering analysis.

Abstract: A prank call server that performs 911 prank call filtering over a 911 emergency call system, prior to routing a 911 call to a PSAP. The inventive prank call server identifies prank calling devices, regardless of current service subscription, by retrieving and analyzing emergency call data pertaining to detected prank 911 calls. The prank call server assigns a unique global identifier to each 911 call detected on the 911 emergency call system. Unique global identifiers enable a PSAP to uniquely identify prank 911 calls that are identified thereon. A PSAP transmits a prank call signal and a relevant unique global identifier to the prank call server, for each prank 911 call that is detected. A prank call signal/unique global identifier combination triggers the prank call server to store all available call data for a referenced prank 911 call in to a prank call database, for subsequent prank call filtering analysis.

Abstract: A prank call server that performs 911 prank call filtering over a 911 emergency call system, prior to routing a 911 call to a PSAP. The inventive prank call server identifies prank calling devices, regardless of current service subscription, by retrieving and analyzing emergency call data pertaining to detected prank 911 calls. The prank call server assigns a unique global identifier to each 911 call detected on the 911 emergency call system. Unique global identifiers enable a PSAP to uniquely identify prank 911 calls that are identified thereon. A PSAP transmits a prank call signal and a relevant unique global identifier to the prank call server, for each prank 911 call that is detected. A prank call signal/unique global identifier combination triggers the prank call server to store all available call data for a referenced prank 911 call in to a prank call database, for subsequent prank call filtering analysis.

Abstract: A prank call server that performs 911 prank call filtering over a 911 emergency call system, prior to routing a 911 call to a PSAP. The inventive prank call server identifies prank calling devices, regardless of current service subscription, by retrieving and analyzing emergency call data pertaining to detected prank 911 calls. The prank call server assigns a unique global identifier to each 911 call detected on the 911 emergency call system. Unique global identifiers enable a PSAP to uniquely identify prank 911 calls that are identified thereon. A PSAP transmits a prank call signal and a relevant unique global identifier to the prank call server, for each prank 911 call that is detected. A prank call signal/unique global identifier combination triggers the prank call server to store all available call data for a referenced prank 911 call in to a prank call database, for subsequent prank call filtering analysis.

Abstract: The invention provides a lysis reagent and method for preparing a test sample for use in an assay, wherein the method yields a homogeneous lysis mixture suitable for use in automated pipetting systems without the need for a centrifugation step. The lysis reagent includes a glycol and an alcohol. Other aspects of the invention include related immunoassays and test kits.

Abstract: Device independent access to stored caller data during an emergency communications event. A call server intercepts an emergency call and determines the capabilities of a calling device. Based on calling device capability, the call server uses one or more of the following device independent methods to ascertain a caller identity, independent of a calling device: interactive voice response redirect, HTTP authentication, SIP INFO method, biometric recognition, human interaction, and alternate number dialing. A caller identity is then used to query a subscriber database for a unique caller profile database key (CPDBK) assigned to the caller (unless a CPDBK is already determined). A call server uses a CPDBK to query a caller profile database (CPDB) for relevant caller data. Relevant caller data and the intercepted emergency communications event are then passed to an emergency call processing system, whereby relevant caller data may be used to more effectively address an emergency situation.

Abstract: An improved extractive reagent composition and method for extracting an immunosuppressant drug, such as sirolimus, tacrolimus or cyclosporine, from blood samples while yielding a test sample extract that has low vapor pressure and is compatible with immunoassay components. The inventive reagent composition comprises dimethyl sulfoxide (DMSO), at least one divalent metal salt and water. The sample extracts resulting from use of each of these combinations have low vapor pressure and are compatible with immunochemistry assays.

Abstract: The invention provides methods of preparing a test sample for use in an assay for detecting an analyte bound by an intracellular ligand. The methods typically involve contacting the test sample with an assay reagent comprising: a lysis reagent; and a protease that has proteolytic activity for said intracellular ligand; to form a mixture compatible for use in an immunoassay without subsequent extraction steps. Other aspects of the invention include related immunoassays and test kits.

Abstract: A prank call server that performs 911 prank call filtering over a 911 emergency call system, prior to routing a 911 call to a PSAP. The inventive prank call server identifies prank calling devices, regardless of current service subscription, by retrieving and analyzing emergency call data pertaining to detected prank 911 calls. The prank call server assigns a unique global identifier to each 911 call detected on the 911 emergency call system. Unique global identifiers enable a PSAP to uniquely identify prank 911 calls that are identified thereon. A PSAP transmits a prank call signal and a relevant unique global identifier to the prank call server, for each prank 911 call that is detected. A prank call signal/unique global identifier combination triggers the prank call server to store all available call data for a referenced prank 911 call in to a prank call database, for subsequent prank call filtering analysis.

Abstract: A timing management node that assigns and adjusts timeout values for a time-constrained complex distributed system based on the nature of a system request, preferences of a customer furnishing a system request, and/or a current state of a complex distributed system. A timing management node evaluates information regarding a system request and information regarding a current state of a complex distributed system to generate timing requirements for the system request. Timing requirements are compiled in a timing policy messager and passed amongst nodes of a complex distributed system with process flow. Timing requirements may be revised during request processing to reflect events that have occurred within the distributed system. A timing policy message contains a timeout value and a total time elapsed parameter for a system request, to permit a complex distributed system to make smarter processing decisions based on a known time remaining to process the given system request.

Abstract: A composition comprising neutrophil gelatinase-associated lipocalin (NGAL), which has been enriched from urine, has a molecular weight of about 24.9 kDa to about 25.9 kDa, and comprises a plurality of isoforms having isoelectric points (pIs) ranging from about 5.9 to about 9.1; a composition comprising NGAL, which has been enriched from recombinant Chinese hamster ovary (CHO) cells, has a molecular weight of about 25.9 kDa to about 27.9 kDa, and comprises a plurality of isoforms having pIs ranging from about 5.6 to about 9.

Abstract: The invention provides methods of preparing a test sample for use in an assay for detecting an analyte bound by an intracellular ligand. The methods typically involve contacting the test sample with an assay reagent comprising: a lysis reagent; and a protease that has proteolytic activity for said intracellular ligand; to form a mixture compatible for use in an immunoassay without subsequent extraction steps. Other aspects of the invention include related immunoassays and test kits.

Abstract: The invention provides methods of preparing a test sample for use in an assay for detecting an analyte bound by an intracellular ligand. The methods typically involve contacting the test sample with an assay reagent comprising: a lysis reagent; and a protease that has proteolytic activity for said intracellular ligand; to form a mixture compatible for use in an immunoassay without subsequent extraction steps. Other aspects of the invention include related immunoassays and test kits.

Abstract: The invention provides a lysis reagent and method for preparing a test sample for use in an assay, wherein the method yields a homogeneous lysis mixture suitable for use in automated pipetting systems without the need for a centrifugation step. The lysis reagent includes a glycol and an alcohol. Other aspects of the invention include related immunoassays and test kits.