Abstract: The present invention refers to an in vitro method for predicting cardiotoxicity risk in a cancer patient receiving, or susceptible to receive, anthracyclines chemotherapy based on the determination of the expression levels of a combination of 10 circulating miRNAs consisting of miRNA 16-5p, miRNA 22-3p, miRNA 30b-5p/30c-5p, miRNA 92b-3p, miRNA 148a-3p, miRNA-150-5p, miRNA-192-5p, miRNA 215-5p, miRNA 486-3p/486-5p and miRNA-4732-3p, in a biological sample isolated from the patient. The present invention also refers to said set of 10 circulating miRNAs for its use as biomarker of prediction of cardiotoxicity risk in cancer patients receiving, or susceptible to receive, anthracyclines chemotherapy. Finally, a method for the prevention of cardiotoxicity, in patients receiving or susceptible to receive anthracyclines chemotherapy, that comprises modulating the expression levels of the set of said 10 circulating miRNAS is contemplated.

Abstract: A method, system, and computer program product for applying materials to a substrate. The method includes determining at least one optical indicium of a substrate based on data received from at least one optical detection system. The method also includes transmitting the at least one optical indicium to at least one edge computing device. The method further includes receiving at least one pattern from the at least one edge computing device. The method further includes controlling at least one robotic unit having at least one robot including at least one nozzle to apply at least one material to the substrate. Controlling the at least one robotic unit includes causing the at least one robotic unit to apply the at least one material to the substrate based on the at least one pattern.

Abstract: An adjustable bed assembly for a vehicle includes a contoured bed frame, a foundation disposed in the bed frame and coupled to an articulated frame having a support platform with a plurality of sectional support members. A linkage mechanism couples the support platform to the foundation and a drive mechanism operably coupled to the linkage assembly adjusts the position of at least one sectional support member. A mattress is disposed on the support platform and configured to conform with the plurality of sectional support members. A monitor mounted on the bed frame is movable between a retracted position and an extended position. A control device has a first preset for concurrently adjusting the articulated frame and moving the monitor.

Abstract: A mold for a dental appliance includes a dental arch portion and a beam. The dental arch portion is associated with teeth of a user. The dental arch portion includes a first distal portion, a second distal portion, and an incisor portion disposed between the first distal portion and the second distal portion. The beam extends from the first distal portion to the second distal portion. The beam includes a label portion disposed between the first distal portion and the second distal portion. The label portion forms a label for identification of the mold.

Abstract: An adjustable bed assembly for a vehicle includes a contoured bed frame, a foundation disposed in the bed frame and coupled to an articulated frame having a support platform with a plurality of sectional support members. A linkage mechanism couples the support platform to the foundation and a drive mechanism operably coupled to the linkage assembly adjusts the position of at least one sectional support member. A mattress is disposed on the support platform and configured to conform with the plurality of sectional support members. A monitor mounted on the bed frame is movable between a retracted position and an extended position. A control device has a first preset for concurrently adjusting the articulated frame and moving the monitor.

Abstract: Seat assemblies and methods for fabricating seat assemblies are provided. In one example, a seat assembly includes a seat base portion. A seat backrest portion is configured to extend substantially upright from the seat base portion. An armrest sub-assembly is configured to move between a stowed position that is one of substantially within and laterally adjacent to the seat backrest portion and an extended position that is generally forward of the seat backrest portion. At least a portion of the armrest sub-assembly translates along an incline relative to the seat base portion during movement from the stowed position towards the extended position.

Abstract: The invention refers to the use of extracts of Deschampsia antarctica (EDA) for counteracting the human skin barrier damage caused by environmental aggressions and for preventing and/or ameliorating disorders related to an impaired barrier function.

Abstract: The present invention relates to a product obtained from gastropod spawn, to be used to prepare dermatological, cosmetic or cosmeceutical compositions designed for skin care; said product has the capacity to activate and mobilize skin stem cells, as well as prevent the loss thereof that takes place as a consequence of chronological and premature ageing. The present invention also relates to the process followed in order to obtain said product.

Abstract: Seat assemblies and methods for fabricating seat assemblies are provided. In one example, a seat assembly includes a seat base portion. A seat backrest portion is configured to extend substantially upright from the seat base portion. An armrest sub-assembly is configured to move between a stowed position that is one of substantially within and laterally adjacent to the seat backrest portion and an extended position that is generally forward of the seat backrest portion. At least a portion of the armrest sub-assembly translates along an incline relative to the seat base portion during movement from the stowed position towards the extended position.

Abstract: The composition comprises of a component A selected from a hydroxylated derivative of benzoic acid or of cinamic acid, their esters, amides or salts, a glycoside of a hexose, and their mixtures; and a component B selected from quinic acid, shikimic acid, their alkaline metal or alkaline earth salts, their methyl esters, and mixtures of the same. This composition is suitable for protecting the skin against ultraviolet radiation coming from the sun or artificial sources, such as those used in phototherapy units and in sun tanning rooms. For application in the field of dermatology and nutrition, and, in particular, in the photoprotection of the skin and mucosa, photo-ageing and photocarcinogenesis, including protection of the immune system associated with the skin.

Abstract: The present invention relates to a product obtained from gastropod spawn, to be used to prepare dermatological, cosmetic or cosmeceutical compositions designed for skin care; said product has the capacity to activate and mobilise skin stem cells, as well as prevent the loss thereof that takes place as a consequence of chronological and premature ageing. The present invention also relates to the process followed in order to obtain said product.

Abstract: The composition comprises of a component A selected from a hydroxylated derivative of benzoic acid or of cinamic acid, their esters, amides or salts, a glycoside of a hexose, and their mixtures; and a component B selected from quinic acid, shikimic acid, their alkaline metal or alkaline earth salts, their methyl esters, and mixtures of the same. This composition is suitable for protecting the skin against ultraviolet radiation coming from the sun or artificial sources, such as those used in phototherapy units and in sun tanning rooms. For application in the field of dermatology and nutrition, and, in particular, in the photoprotection of the skin and mucosa, photo-ageing and photocarcinogenesis, including protection of the immune system associated with the skin.

Abstract: A hydraulic actuator is provided for supporting a load. The actuator includes a cylinder, a lower end closed by a base, and an annular side wall connected between the base and the upper wall. A piston is disposed partially within the cylinder, and includes a rod extending through the upper end of the cylinder, and a piston head that defines a hydraulic chamber with the base. A cylinder chamber is disposed between the base and the piston head and communicates with a fluid source and a fluid return to correspondingly extend and retract the piston. A support member is connected to the cylinder wall, and can be raised to support a tilt saddle member between the piston rod and the load after the piston has been extended.

Abstract: The composition comprises of a component A selected from a hydroxylated derivative of benzoic acid or of cinamic acid, their esters, amides or salts, a glycoside of a hexose, and their mixtures; and a component B selected from quinic acid, shikimic acid, their alkaline metal or alkaline earth salts, their methyl esters, and mixtures of the same. This composition is suitable for protecting the skin against ultraviolet radiation coming from the sun or artificial sources, such as those used in phototherapy units and in sun tanning rooms. For application in the field of dermatology and nutrition, and, in particular, in the photoprotection of the skin and mucosa, photo-ageing and photocarcinogenesis, including protection of the immune system associated with the skin.