Abstract: In one aspect, methods of diagnosing a subject as having Alzheimer's disease and prognosing a subject as being at risk of progressing to Alzheimer's disease are provided. In some embodiments, the method comprises determining one or more of the level of expression of rhotekin 2 (RTKN2), the level of expression of microtubule-associated Ser/Thr kinase 4 (MAST4), the level of binding of forkhead box O1 (FOXO1) to the RTKN2 promoter, and the level of binding of amyloid precursor protein (APP) to the MAST4 promoter in a sample from the subject.

Abstract: In one aspect, methods of diagnosing a subject as having Alzheimer's disease and prognosing a subject as being at risk of progressing to Alzheimer's disease are provided. In some embodiments, the method comprises determining one or more of the level of expression of rhotekin 2 (RTKN2), the level of expression of microtubule-associated Ser/Thr kinase 4 (MAST4), the level of binding of forkhead box O1 (FOXO1) to the RTKN2 promoter, and the level of binding of amyloid precursor protein (APP) to the MAST4 promoter in a sample from the subject.

Abstract: Provided here are methods of treating Niemann-Pick disease type C (NPC) in a subject or delaying the onset of NPC in a subject by administering to the subject an immunomodulator, or a modulator of amyloid precursor protein (APP) function, or a combination thereof.

Abstract: A molded part includes a plurality of surfaces and an embossment extending from one of the plurality of surfaces. The embossment includes a body and a bore extending through a central portion of the body. The embossment further includes a first pocket extending through a sidewall of the body and into the bore and a second pocket extending through an opposite sidewall of the body and into the bore. The first pocket and the second pocket each define inwardly tapered walls. The first pocket and the second pocket are spaced axially along the body and are diametrically opposed.

Abstract: In one aspect, methods of reversing or delaying the progression of Alzheimer's disease in a subject having Alzheimer's disease or delaying the onset of Alzheimer's disease in a subject having mild cognitive impairment are provided. In some embodiments, the method comprises administering to the subject an oxysterol inhibitor.

Abstract: Systems and methods for identifying abnormal movements or tremors in one or more human subjects. Kinetic and/or electromyographic sensors are employed in detection hardware to detect voluntary and involuntary movements. The data collected from such voluntary and involuntary movement detection can be further processed and compared to baseline data to identify and distinguish abnormal movements from normal movements. The identification of abnormal movements may indicate a neurodegenerative disorder.

Abstract: In one aspect, methods of diagnosing a subject as having Alzheimer's disease and prognosing a subject as being at risk of progressing to Alzheimer's disease are provided. In some embodiments, the method comprises determining one or more of the level of expression of rhotekin 2 (RTKN2), the level of expression of microtubule-associated Ser/Thr kinase 4 (MAST4), the level of binding of forkhead box O1 (FOXO1) to the RTKN2 promoter, and the level of binding of amyloid precursor protein (APP) to the MAST4 promoter in a sample from the subject.

Abstract: Methods are disclosed for determining a patient's risk for developing Alzheimer's disease and preventing or treating Alzheimer's disease. Kits for assessing a patient's risk of developing Alzheimer's are also provided.

Abstract: A vehicle overhead console is provided which includes a conversation mirror assembly having a housing capable of storing a conversation mirror. The conversation mirror may travel between a stored and a use position. The conversation mirror is releasably secured to the stored and use positions by way of magnetic, tab, and spring arrangements.

Abstract: Methods are disclosed for determining a patient's risk for developing Alzheimer's disease and preventing or treating Alzheimer's disease. Kits for assessing a patient's risk of developing Alzheimer's are also provided.

Abstract: A vehicle overhead console is provided which includes a conversation mirror assembly having a housing capable of storing a conversation mirror. The conversation mirror may travel between a stored and a use position. The conversation mirror is releasably secured to the stored and use positions by way of magnetic, tab, and spring arrangements.