Abstract: The expandable sheaths disclosed herein include an expandable outer layer and a generally non-expandable inner layer. The outer layer is movable between a non-expanded configuration and an expanded configuration, where the outer layer/tubular layer is biased to the non-expanded configuration. Receipt of the inner layer within the central lumen of the outer layer causes the outer layer to transition from the non-expanded configuration to the expanded configuration.

Abstract: A sheath locking system comprising an introducer locking hub comprising a hub body defining a locking channel for engaging a corresponding guide on a sheath locking sleeve. The sheath locking sleeve removably coupled to the introducer locking hub via engagement between the guide and the locking channel. The sheath locking sleeve movable between an unlocked position where the sheath locking sleeve is rotationally and axially movable with respect to the introducer locking hub, and a locked position where the sheath locking sleeve is axially fixed with respect to the introducer locking hub.

Abstract: A release mechanism for a delivery apparatus and associated methods for operating the release mechanism are disclosed. As one example, a handle portion of the delivery apparatus can include a release mechanism configured to adjust a linear position of a component of the delivery apparatus. The release mechanism can include a threaded drive screw including one or more retaining elements arranged at a proximal end of the drive screw and one or more grooves forming a helical threaded portion of the drive screw that each extend from a corresponding retaining element to a distal end of the drive screw, the drive screw coupled to the component; and a rotatable knob surrounding and coaxial with the drive screw, the knob including one or more teeth arranged at a proximal end of the knob, each tooth configured to interface with a corresponding retaining element and groove of the drive screw.

Abstract: Disclosed herein is a delivery apparatus used to introduce a prosthetic device, such as a heart valve or other implant, into a patient's vasculature. The delivery apparatus includes a sheath member defining a tubular structure and a tip portion provided at the distal end of the sheath member. The inner surface of the tip portion includes structure for directing expansion of the heart valve during delivery and/or also directing folding and/or crimping of the prosthetic heart valve as it is withdrawn back into the sheath.

Abstract: The present disclosure generally relates to systems, devices, and methods for delivery systems including deflectable elongate shafts. A delivery system may include a deflectable elongate shaft including a pull tether extending along the length of the elongate shaft and having a distal portion and a proximal portion and an intermediate portion, with the distal portion of the pull tether coupled to a portion of the elongate shaft such that the intermediate portion of the pull tether may variably move towards the first set of bi-directional cuts or the second set of bi-directional cuts. The pull tether may be configured to be pulled to deflect the hypotube.

Abstract: Fluid separation chambers are provided for rotation about an axis in a fluid processing system. The fluid separation chamber may be provided with first and second stages, with the first and second stages being positioned at different axial locations. In another embodiment, at least one of the stages may be provided with a non-uniform outer diameter about the rotational axis, which may define a generally spiral-shaped profile or a different profile for fractionating a fluid or fluid component. One or more of the stages may also have a varying outer diameter along the axis. The profile of the chamber may be provided by the chamber itself (in the case of rigid chambers) or by an associated fixture or centrifuge apparatus (in the case of flexible chambers).

Abstract: Fluid separation chambers are provided for rotation about an axis in a fluid processing system. The fluid separation chamber may be provided with first and second stages, with the first and second stages being positioned at different axial locations. In another embodiment, at least one of the stages may be provided with a non-uniform outer diameter about the rotational axis, which may define a generally spiral-shaped profile or a different profile for fractionating a fluid or fluid component. One or more of the stages may also have a varying outer diameter along the axis. The profile of the chamber may be provided by the chamber itself (in the case of rigid chambers) or by an associated fixture or centrifuge apparatus (in the case of flexible chambers).

Abstract: Fluid separation chambers are provided for rotation about an axis in a fluid processing system. The fluid separation chamber may be provided with first and second stages, with the first and second stages being positioned at different axial locations. In another embodiment, at least one of the stages may be provided with a non-uniform outer diameter about the rotational axis, which may define a generally spiral-shaped profile or a different profile for fractionating a fluid or fluid component. One or more of the stages may also have a varying outer diameter along the axis. The profile of the chamber may be provided by the chamber itself (in the case of rigid chambers) or by an associated fixture or centrifuge apparatus (in the case of flexible chambers).

Abstract: Fluid separation chambers are provided for rotation about an axis in a fluid processing system. The fluid separation chamber may be provided with first and second stages, with the first and second stages being positioned at different axial locations. In another embodiment, at least one of the stages may be provided with a non-uniform outer diameter about the rotational axis, which may define a generally spiral-shaped profile or a different profile for fractionating a fluid or fluid component. One or more of the stages may also have a varying outer diameter along the axis. The profile of the chamber may be provided by the chamber itself (in the case of rigid chambers) or by an associated fixture or centrifuge apparatus (in the case of flexible chambers).

Abstract: Fluid separation chambers are provided for rotation about an axis in a fluid processing system. The fluid separation chamber may be provided with first and second stages, with the first and second stages being positioned at different axial locations. In another embodiment, at least one of the stages may be provided with a non-uniform outer diameter about the rotational axis, which may define a generally spiral-shaped profile or a different profile for fractionating a fluid or fluid component. One or more of the stages may also have a varying outer diameter along the axis. The profile of the chamber may be provided by the chamber itself (in the case of rigid chambers) or by an associated fixture or centrifuge apparatus (in the case of flexible chambers).

Abstract: A sheeting is provided for use with a fluid processing cassette having a valve station with a plurality of fluid flow ports. The sheeting has a generally flexible layer and a biasing member associated with the layer. The sheeting is attached to the cassette such that the biasing member is received within the valve station. The cassette may be used with a fluid processing system having a valve actuator with a piston that is aligned with the cassette during use. In an extended position, the piston presses the sheeting against the port to prevent fluid flow through the valve station. When the piston moves from the extended position to a retracted position, it allows the sheeting to uncover the port, thereby allowing fluid flow through the valve station. The biasing member assists in displacing the sheeting from the port when the piston moves to the retracted position.

Abstract: Centrifuges are provided for rotating fluid separation chambers about an axis in a fluid processing system. The centrifuge may be provided with high- and low-G walls, with a gap defined between the high- and low-G walls. A first section of the gap may have a substantially uniform radius about the axis, while a second section of the gap may have a non-uniform radius about the axis. The radius of the second section of the gap about the axis at all locations is no larger than the radius of the first section of the gap about the axis. The high-G wall may comprise an inner surface of an outer bowl, while the low-G wall may comprise an outer surface of an inner spool. At least a portion of the second section of the gap may have a varying radius along the axis and/or be configured as a spiral.

Abstract: An irradiation device includes a fluid treatment chamber configured to receive a biological fluid container, the fluid treatment chamber having opposing first and second sides, at least one light source disposed adjacent at least one of the first and second sides of the fluid treatment chamber, and an overflow reservoir in fluid communication with the fluid treatment chamber to receive fluid leaking from the biological fluid container. The device also includes a non-contact sensor disposed adjacent the overflow reservoir and configured to generate a signal according to leaked fluid in the overflow reservoir, an indicator, and a controller coupled to the at least one light source, the non-contact sensor and the indicator, the controller configured to activate the indicator upon receipt of the signal from the sensor and to deactivate the at least one light source subsequent to receipt of the signal from the sensor.

Abstract: A medical device position guidance system having a noninvasive medical device communicable with an invasive medical device. The system provides outputs useful to assess the position of an invasive medical device in an animal, such as a human. A magnetic field is used to gather information about the position of the invasive device. Radio waves are used to communicate this information between the noninvasive device and the invasive device.

Abstract: An irradiation device includes a fluid treatment chamber configured to receive a biological fluid container, the fluid treatment chamber having opposing first and second sides, at least one light source disposed adjacent at least one of the first and second sides of the fluid treatment chamber, and an overflow reservoir in fluid communication with the fluid treatment chamber to receive fluid leaking from the biological fluid container. The device also includes a non-contact sensor disposed adjacent the overflow reservoir and configured to generate a signal according to leaked fluid in the overflow reservoir, an indicator, and a controller coupled to the at least one light source, the non-contact sensor and the indicator, the controller configured to activate the indicator upon receipt of the signal from the sensor and to deactivate the at least one light source subsequent to receipt of the signal from the sensor.

Abstract: Fluid separation chambers are provided for rotation about an axis in a fluid processing system. The fluid separation chamber may be provided with first and second stages, with the first and second stages being positioned at different axial locations. In another embodiment, at least one of the stages may be provided with a non-uniform outer diameter about the rotational axis, which may define a generally spiral-shaped profile or a different profile for fractionating a fluid or fluid component. One or more of the stages may also have a varying outer diameter along the axis. The profile of the chamber may be provided by the chamber itself (in the case of rigid chambers) or by an associated fixture or centrifuge apparatus (in the case of flexible chambers).

Abstract: A sheeting is provided for use with a fluid processing cassette having a valve station with a plurality of fluid flow ports. The sheeting has a generally flexible layer and a biasing member associated with the layer. The sheeting is attached to the cassette such that the biasing member is received within the valve station. The cassette may be used with a fluid processing system having a valve actuator with a piston that is aligned with the cassette during use. In an extended position, the piston presses the sheeting against the port to prevent fluid flow through the valve station. When the piston moves from the extended position to a retracted position, it allows the sheeting to uncover the port, thereby allowing fluid flow through the valve station. The biasing member assists in displacing the sheeting from the port when the piston moves to the retracted position.

Abstract: A clamping apparatus is provided for use with a fluid flow device, such as a blood separation system. The clamping apparatus includes a clamp head at least partially defining first and second tube openings each to receive tubing. The clamping apparatus also includes a first actuator coupled to a first flow control member. The first flow control member is configured to be movable via the first actuator relative to the first tube opening to control fluid flow through tubing located in the first tube opening. The clamping apparatus further includes a second actuator coupled to a second flow control member. The second flow control member is movable via the second actuator relative to the second tube opening to control fluid flow through tubing located in the second tube opening.