Patents by Inventor Salvatore Pernagallo

Salvatore Pernagallo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NANOSYSTEMS FOR CONTROLLED TRANSPORT OF ACTIVE MOLECULES FOR DIAGNOSTIC, PROGNOSTIC AND THERAPEUTIC PURPOSES
    Publication number: 20230056857
    Abstract: Disclosed is a nanoparticle system consisting of a polymer support or substrate in the form of nanoparticles to which a hydrolase enzyme able to degrade hyaluronic acid and one or more biologically and/or pharmacologically active molecules are covalently bonded, its preparation process and its uses in the diagnostic, prognostic and therapeutic fields.
    Type: Application
    Filed: October 28, 2022
    Publication date: February 23, 2023
    Applicants: FIDIA FARMACEUTICI S.P.A., NANOGETIC S.L.
    Inventors: Rosario Maria SANCHEZ MARTIN, Salvatore PERNAGALLO, Juan Diego UNCITI BROCETA, Luciano MESSINA, Susanna VACCARO, Laura PILOTTO
  • Nanosystems for controlled transport of active molecules for diagnostic, prognostic and therapeutic purposes
    Patent number: 11510995
    Abstract: Disclosed is a nanoparticle system consisting of a polymer support or substrate in the form of nanoparticles to which a hydrolase enzyme able to degrade hyaluronic acid and one or more biologically and/or pharmacologically active molecules are covalently bonded, its preparation process and its uses in the diagnostic, prognostic and therapeutic fields.
    Type: Grant
    Filed: December 20, 2016
    Date of Patent: November 29, 2022
    Assignees: FIDIA FARMACEUTICI S.P.A., NANOGETIC S.L.
    Inventors: Rosario Maria Sanchez Martin, Salvatore Pernagallo, Juan Diego Unciti Broceta, Luciano Messina, Susanna Vaccaro, Laura Pilotto
  • PNA probe
    Patent number: 11242526
    Abstract: Disclosed herein are improved PNA based monomers, nucleobases, oligomers and probes for use in a variety of different methods of analysing nucleic acids. Further, the disclosure provides methods of preparing the modified and improved PNA molecules as well as methods of using the same.
    Type: Grant
    Filed: July 12, 2017
    Date of Patent: February 8, 2022
    Assignee: Destina Genomica S.L.
    Inventors: Hugh Alexander Ilyine, Juan J. Diaz-Mochon, Salvatore Pernagallo, Mavys Tabraue Chavez, Mario Antonio Fara
  • SINGLE MOLECULE DETECTION AND QUANTIFICATION OF NUCLEIC ACIDS WITH SINGLE BASE SPECIFICITY
    Publication number: 20200123592
    Abstract: Methods for detecting nucleic acids, particularly small nucleic acids such as microRNAs, involving the use of a peptide nucleic acid (PNA) probe that lacks a base and a labelled modified base corresponding to the omitted base in the PNA probe. A complex containing the target nucleic acid, the PNA probe, and the modified base can be determined using a single molecule array assay.
    Type: Application
    Filed: May 29, 2018
    Publication date: April 23, 2020
    Applicants: Quanterix Corporation, DestiNA Genomics Ltd.
    Inventors: Juan J. Díaz-Mochón, David C. Duffy, Salvatore Pernagallo, Hugh llyine, David M. Rissin, Barbara López-Longarela
  • IMPROVED PNA PROBE
    Publication number: 20190233818
    Abstract: Disclosed herein are improved PNA based monomers, nucleobases, oligomers and probes for use in a variety of different methods of analysing nucleic acids. Further, the disclosure provides methods of preparing the modified and improved PNA molecules as well as methods of using the same.
    Type: Application
    Filed: July 12, 2017
    Publication date: August 1, 2019
    Inventors: Hugh Alexander Ilyine, Juan J. Diaz-Mochon, Salvatore Pernagallo, Mavys Tabraue Chavez, Mario Antonio Fara
  • NANOSYSTEMS FOR CONTROLLED TRANSPORT OF ACTIVE MOLECULES FOR DIAGNOSTIC, PROGNOSTIC AND THERAPEUTIC PURPOSES
    Publication number: 20180360990
    Abstract: Disclosed is a nanoparticle system consisting of a polymer support or substrate in the form of nanoparticles to which a hydrolase enzyme able to degrade hyaluronic acid and one or more biologically and/or pharmacologically active molecules are covalently bonded, its preparation process and its uses in the diagnostic, prognostic and therapeutic fields.
    Type: Application
    Filed: December 20, 2016
    Publication date: December 20, 2018
    Applicants: FIDIA FARMACEUTICI S.P.A., NANOGETIC S.L.
    Inventors: Rosario Maria SANCHEZ MARTIN, Salvatore PERNAGALLO, Juan Diego UNCITI BROCETA, Luciano MESSINA, Susanna VACCARO, Laura PILOTTO
  • POLYMERS FOR GROWING CELLS
    Publication number: 20120052525
    Abstract: The present invention provides a polymer substrate for use in the attachment and functioning of hepatocyte and hepatocyte like cells. In particular, the polymer substrate is a polyurethane polymer.
    Type: Application
    Filed: March 19, 2010
    Publication date: March 1, 2012
    Inventors: David C. Hay, John P. Iredale, Mark Bradley, Juan J. Diaz-Mochon, Salvatore Pernagallo