Patents by Inventor Salvatore S. Margherita

Salvatore S. Margherita has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Radioimmunoassay methods for the determination of L-triiodothyronine and thyroxine
    Patent number: 4111656
    Abstract: An improved, simplified radioimmunoassay method for the in vitro determination of L-triiodothyronine in unextracted blood serum involves the use of a combination reagent constituted by a buffered solution containing radioactive L-triiodothyronine and an inhibitor for inhibiting binding of L-triiodothyronine to thyroxine-binding globulin. Optionally the reagent may also include an antiserum containing antibody capable of immunoreactivity with L-triiodothyronine. Packaged test kits for use in conveniently carrying out the radioimmunoassay are also provided. Certain salts of 8-anilino-1-naphthalene sulfonic acid, which may be regarded as purified forms of the acid, are preferably employed as inhibitors for inhibiting binding of L-triiodothyronine to thyroxine-binding globulin.
    Type: Grant
    Filed: May 21, 1976
    Date of Patent: September 5, 1978
    Assignee: Mallinckrodt, Inc.
    Inventor: Salvatore S. Margherita
  • Radioimmunoassay methods for the determination of L-triiodothyronine and thyroxine
    Patent number: 4110076
    Abstract: An improved, simplified radioimmunoassay method for the in vitro determination of L-triiodothyronine in unextracted blood serum involves the use of a combination reagent constituted by a buffered solution containing radioactive L-triiodothyronine and an inhibitor for inhibiting binding of L-triiodothyronine to thyroxine-binding globulin. Optionally the reagent may also include an antiserum containing antibody capable of immunoreactivity with L-triiodothyronine. Packaged test kits for use in conveniently carrying out the radioimmunoassay are also provided. Certain salts of 8-anilino-1-naphthalene sulfonic acid, which may be regarded as purified forms of the acid, are preferably employed as inhibitors for inhibiting binding of L-triiodothyronine to thyroxine-binding globulin.
    Type: Grant
    Filed: August 11, 1976
    Date of Patent: August 29, 1978
    Assignee: Mallinckrodt, Inc.
    Inventor: Salvatore S. Margherita