Abstract: The present disclosure provides macrocyclic compounds inspired by the immunophilin ligand family of natural products FK506 and rapamycin. The generation of a Rapafucin library of macrocyles that contain FK506 and rapamycin binding domains should have great potential as new leads for developing drugs to be used for treating diseases.

Abstract: A compound of Formula I, and its analogs are provided. Compositions that include Formula I can be used to inhibit human equilibrative nucleoside transporter 1, increase adenosine signaling and produce effects that include increasing antiviral activity, increasing antiparasitic activity, increasing alcohol tolerance, decreasing pain protecting from ischemia as well as many other conditions.

Abstract: The present disclosure provides macrocyclic compounds inspired by the immunophilin ligand family of natural products FK506 and rapamycin. The generation of a Rapafucin library of macrocyles that contain FK506 and rapamycin binding domains should have great potential as new leads for developing drugs to be used for treating diseases.

Abstract: The present disclosure provides neuroprotective compounds along with their use in treating disease such as Parkinson's disease (PD). The compounds can be used as inhibitors for Parthanatos Associated AIF (apoptosis-inducing factor) Nuclease (PAAN), also known as macrophage migration inhibitor factor (MIF).

Abstract: The present disclosure provides macrocyclic compounds inspired by the immunophilin ligand family of natural products FK506 and rapamycin. The generation of a Rapafucin library of macrocyles that contain FK506 and rapamycin binding domains should have great potential as new leads for developing drugs to be used for treating diseases.

Abstract: A machine-readable medium can include instructions for presenting a user interface, which when executed by a processor, can cause the processor to display an image on the user interface representing a mobile cleaning robot that is in communication with the processor. The processor can also display lines representing an environment of the mobile cleaning robot, where the image and the lines can together be indicative of a status of the mobile cleaning robot.

Abstract: Described herein are systems, devices, and methods for scheduling and controlling a mobile robot using a textual and user experienced-based mission routine. In an example, a mobile cleaning robot comprises a drive system to move the mobile cleaning robot about an environment, a sensor circuit to detect an object in the environment, and a controller circuit to receive a mission routine including data representing an editable schedule including at least one of time or order for performing one or more cleaning tasks with respect to a semantically annotated object that include spatial or contextual information of the detected object, or with respect to user experience or user behavior. The controller circuit navigates the mobile cleaning robot to conduct a mission in accordance with the mission routine.

Abstract: The present disclosure provides macrocyclic compounds inspired by the immunophilin ligand family of natural products FK506 and rapamycin. The generation of a Rapafucin library of macrocyles that contain FK506 and rapamycin binding domains should have great potential as new leads for developing drugs to be used for treating diseases.

Abstract: The present disclosure provides macrocyclic compounds inspired by the immunophilin ligand family of natural products FK506 and rapamycin. The generation of a Rapafucin library of macrocyles that contain FK506 and rapamycin binding domains should have great potential as new leads for developing drugs to be used for treating diseases.

Abstract: A display panel may include the following elements: a substrate; a first-color filter, which overlaps the substrate and may include a first-color portion and a first-color part; a second-color filter, which may include a second-color portion and a second-color part; a third-color filter, which may include a third-color portion and a third-color part; a light-blocking structure, which may be positioned between the first-color part and the second-color part in a plan view of the display panel and may include the first-color portion, the second-color portion, and the third-color portion, wherein the first-color portion, the second-color portion, and the third-color portion are stacked in a direction perpendicular to the substrate.

Abstract: A compound of Formula I, and its analogs are provided. Compositions that include Formula I can be used to inhibit human equilibrative nucleoside transporter 1, increase adenosine signaling and produce effects that include increasing antiviral activity, increasing antiparasitic activity, increasing alcohol tolerance, decreasing pain protecting from ischemia as well as many other conditions.

Abstract: A compound of Formula (I), and its analogs are provided. Compositions that include Formula I can be used to inhibit human equilibrative nucleoside transporter 1, increase adenosine signaling and produce effects that include increasing antiviral activity, increasing antiparasitic activity, increasing alcohol tolerance, decreasing pain protecting from ischemia as well as many other conditions.

Abstract: A Rapafucin library containing compounds of the general structure, (A) and (E), and a synthesis of these compounds are provided.

Abstract: A display panel may include the following elements: a substrate; a first-color filter, which overlaps the substrate and may include a first-color portion and a first-color part; a second-color filter, which may include a second-color portion and a second-color part; a third-color filter, which may include a third-color portion and a third-color part; a light-blocking structure, which may be positioned between the first-color part and the second-color part in a plan view of the display panel and may include the first-color portion, the second-color portion, and the third-color portion, wherein the first-color portion, the second-color portion, and the third-color portion are stacked in a direction perpendicular to the substrate.

Abstract: The present disclosure provides macrocyclic compounds inspired by the immunophilin ligand family of natural products FK506 and rapamycin. The generation of a Rapafucin library of macrocyles that contain FK506 and rapamycin binding domains should have great potential as new leads for developing drugs to be used for treating diseases.

Abstract: A display panel may include the following elements: a substrate; a first-color filter, which overlaps the substrate and may include a first-color portion and a first-color part; a second-color filter, which may include a second-color portion and a second-color part; a third-color filter, which may include a third-color portion and a third-color part; a light-blocking structure, which may be positioned between the first-color part and the second-color part in a plan view of the display panel and may include the first-color portion, the second-color portion, and the third-color portion, wherein the first-color portion, the second-color portion, and the third-color portion are stacked in a direction perpendicular to the substrate.

Abstract: Disclosed in certain embodiments is a composition comprising a first material; an adhesive material attached to the first material; a plurality of linker molecules bonded to the adhesive material; and a second material bonded to the linker molecules.

Abstract: A Rapafucin library containing compounds of the general structure, (A) and (E), and a synthesis of these compounds are provided.

Abstract: A compound of Formula (I), and its analogs are provided. Compositions that include Formula I can be used to inhibit human equilibrative nucleoside transporter 1, increase adenosine signaling and produce effects that include increasing antiviral activity, increasing antiparasitic activity, increasing alcohol tolerance, decreasing pain protecting from ischemia as well as many other conditions.

Abstract: A weaning readiness indicator is disclosed. The weaning readiness indicator includes a monitor, a memory, a processor, and a display. The monitor monitors a ventilated patient for a predetermined time length and generates a respiratory signal. The memory stores an algorithm, where the algorithm includes performing a nonlinear time frequency analysis on the respiratory signal to obtain a time frequency representation function, extracting one or more features from the time frequency representation function, and computing a weaning readiness index based on the one or more features. The processor is connected to the monitor and the memory, and executes the algorithm. The display is connected to the processor and provides an indication of the weaning readiness index of the ventilated patient. A sleeping status recording device and an air providing system applying nonlinear time frequency analysis are also disclosed.