Abstract: Disclosed herein are methods of treating a toxicity in a subject receiving recombinant viral vector, such as a recombinant adeno-associated viral AAV (rAAV) vector comprising co-administration of an antibiotic and a viral vector. In one embodiment, the antibiotic is a tetracycline or macrolide family member. Also provided herein are compositions comprising an antibiotic and a viral vector.

Abstract: An extended area filter is provided. The extended area filter has sheets of a filter media configured for increased filter media surface area. A plurality of filter media tubes are position in a concentric arrangement about a longitudinal axis of the filter, defining annular inlet volumes and annular outlet volumes, the annular inlet volumes receiving an unfiltered fluid, and the outlet volumes receiving a filtrate passed through the tubes of filter media. Internal support elements suitable for placement within the outlet volumes are also provided. A filter apparatus configured for filtering a contaminated fluid and employing extended area filters of the invention is also provided.

Abstract: An extended area filter is provided. The extended area filter has sheets of a filter media configured for increased filter media surface area. A plurality of filter media tubes are position in a concentric arrangement about a longitudinal axis of the filter, defining annular inlet volumes and annular outlet volumes, the annular inlet volumes receiving an unfiltered fluid, and the outlet volumes receiving a filtrate passed through the tubes of filter media. A filter apparatus configured for filtering a contaminated fluid and employing extended area filters of the invention is also provided.

Abstract: A particle control screen assembly for a perforated pipe used in a well. The particle control screen assembly includes a screen with a first end and a second end. The screen includes a first and a second unsintered woven mesh layer, each layer having a first longitudinal edge and a second longitudinal edge. The cylindrical screen also includes openings sized to prevent passage of particulate material and a longitudinal metal weld adjacent the first and second longitudinal edges of the first and second unsintered woven mesh layers. The longitudinal metal weld secures the edges of the unsintered woven mesh layers together. The particle control screen assembly also includes a weld-compatible metal structure adjacent the first end of the cylindrical screen. A circumferential metal weld between the cylindrical screen and the metal structure bonds a portion of the metal structure and a portion of the cylindrical screen.

Abstract: A particle control screen includes a support layer. A first filter layer is disposed around the support layer. A second filter layer is disposed around the first filter layer. A third filter layer is disposed around the second filter layer. Each of the filter layers has a pore size. The pore size of the third filter layer is greater than the pore size of the second filter layer. The pore size of the second filter layer is greater than the pore size of the first filter layer.

Abstract: A particle control screen includes a support layer. A first filter layer is disposed around the support layer. A second filter layer is disposed around the first filter layer. A third filter layer is disposed around the second filter layer. Each of the filter layers has a pore size. The pore size of the third filter layer is greater than the pore size of the second filter layer. The pore size of the second filter layer is greater than the pore size of the first filter layer.

Abstract: A particle control screen assembly for a perforated pipe used in a well. The particle control screen assembly includes a screen with a first end and a second end. The screen includes a first and a second unsintered woven mesh layer, each layer having a first longitudinal edge and a second longitudinal edge. The cylindrical screen also includes openings sized to prevent passage of particulate material and a longitudinal metal weld adjacent the first and second longitudinal edges of the first and second unsintered woven mesh layers. The longitudinal metal weld secures the edges of the unsintered woven mesh layers together. The particle control screen assembly also includes a weld-compatible metal structure adjacent the first end of the cylindrical screen. A circumferential metal weld between the cylindrical screen and the metal structure bonds a portion of the metal structure and a portion of the cylindrical screen.

Abstract: An expandable well screen has a desirable thin-wall construction together with a simplified fabrication method. In fabricating the screen, a flexible sheet of metal mesh filter media is diffusion bonded to an inner side of a perforated metal sheet which is then deformed to a tubular shape to form a filter structure having an outer perforated tubular shroud interiorly lined with the filter media. The tubular filter structure is telescoped onto a perforated base pipe and has its opposite ends sealingly secured thereto to complete the expandable well screen.

Abstract: An expandable well screen has a desirable thin-wall construction together with a simplified fabrication method. In fabricating the screen, a flexible sheet of metal mesh filter media is diffusion bonded to an inner side of a perforated metal sheet which is then deformed to a tubular shape to form a filter structure having an outer perforated tubular shroud interiorly lined with the filter media. The tubular filter structure is telescoped onto a perforated base pipe and has its opposite ends sealingly secured thereto to complete the expandable well screen.

Abstract: An expandable well screen has a desirable thin-wall construction together with a simplified fabrication method. In fabricating the screen, a flexible sheet of metal mesh filter media is diffusion bonded to an inner side of a perforated metal sheet which is then deformed to a tubular shape to form a filter structure having an outer perforated tubular shroud interiorly lined with the filter media. The tubular filter structure is telescoped onto a perforated base pipe and has its opposite ends sealingly secured thereto to complete the expandable well screen.

Abstract: An expandable well screen has a desirable thin-wall construction together with a simplified fabrication method. In fabricating the screen, a flexible sheet of metal mesh filter media is diffusion bonded to an inner side of a perforated metal sheet which is then deformed to a tubular shape to form a filter structure having an outer perforated tubular shroud interiorly lined with the filter media. The tubular filter structure is telescoped onto a perforated base pipe and has its opposite ends sealingly secured thereto to complete the expandable well screen.

Abstract: An expandable well screen has a desirable thin-wall construction together with a simplified fabrication method. In fabricating the screen, a flexible sheet of metal mesh filter media is diffusion bonded to an inner side of a perforated metal sheet which is then deformed to a tubular shape to form a filter structure having an outer perforated tubular shroud interiorly lined with the filter media. The tubular filter structure is telescoped onto a perforated base pipe and has its opposite ends sealingly secured thereto to complete the expandable well screen.

Abstract: An expandable well screen has a desirable thin-wall construction together with a simplified fabrication method. In fabricating the screen, a flexible sheet of metal mesh filter media is diffusion bonded to an inner side of a perforated metal sheet which is then deformed to a tubular shape to form a filter structure having an outer perforated tubular shroud interiorly lined with the filter media. The tubular filter structure is telescoped onto a perforated base pipe and has its opposite ends sealingly secured thereto to complete the expandable well screen.

Abstract: An expandable well screen has a desirable thin-wall construction together with a simplified fabrication method. In fabricating the screen, a flexible sheet of metal mesh filter media is diffusion bonded to an inner side of a perforated metal sheet which is then deformed to a tubular shape to form a filter structure having an outer perforated tubular shroud interiorly lined with the filter media. The tubular filter structure is telescoped onto a perforated base pipe and has its opposite ends sealingly secured thereto to complete the expandable well screen.