Abstract: Provided herein are optical probes to enhance the accessible volume imaged with a microscope, and systems and methods for inserting the optical probes into an object for imaging of the interior of the object. The object can be a tissue of a living organism. The probe can continuously image the space in the vicinity of the probe as the probe is inserted into the object. The probe can image a sample at an angle great than 0° relative to the implantation axis of the probe. The probe can be connected to a surface of the object by a cuff. The cuff can comprise one or more surface features to increase a surface area of the cuff that attaches to the surface of the object. The cuff can be held by a clamp while the probe is inserted into the object for imaging.