Abstract: The present disclosure is generally directed to the use of compositions that include antibodies, e.g., monoclonal, chimeric, affinity-matured or humanized antibodies, antibody fragments, etc., that specifically bind one or more epitopes within a Sortilin protein, e.g., human Sortilin or mammalian Sortilin, and have improved and/or enhanced functional characteristics, in treating and/or delaying progression of a disease or injury in an individual in need thereof.

Abstract: Methods of improving visual endpoints related to retina-associated disease with CCR3 modulating agents are provided. An example of such an endpoint is visual acuity. Retina-associated diseases upon which visual acuity and other visual endpoints may be improved include retinopathy of prematurity, age-related macular degeneration, central retinal vein occlusion, and diabetic retinopathy.

Abstract: Articles of footwear and methods of making articles of footwear including one or more continuous threads wound around anchor points. The winding of the one or more continuous threads forms a thread pattern that imparts desired characteristics to components of the article of footwear. Thread lines of the thread pattern may be bonded together. In some embodiments, thread lines may be bonded with a bonding layer.

Abstract: Methods of improving visual endpoints related to retina-associated disease with CCR3 modulating agents are provided. An example of such an endpoint is visual acuity. Retina-associated diseases upon which visual acuity and other visual endpoints may be improved include retinopathy of prematurity, age-related macular degeneration, central retinal vein occlusion, and diabetic retinopathy.

Abstract: The present disclosure is generally directed to the use of compositions that include antibodies, e.g., monoclonal, chimeric, affinity-matured, humanized antibodies, antibody fragments, etc., that specifically bind one or more epitopes within a TREM2 protein, e.g., human TREM2, for use in treating and/or delaying progression of a disease or injury in an individual in need thereof.

Abstract: Methods of improving visual endpoints related to retina-associated disease with CCR3 modulating agents are provided. An example of such an endpoint is visual acuity. Retina-associated diseases upon which visual acuity and other visual endpoints may be improved include retinopathy of prematurity, age-related macular degeneration, central retinal vein occlusion, and diabetic retinopathy.

Abstract: Methods and compositions for treating and/or preventing aging-related conditions are described. The compositions used in the methods include blood plasma and blood plasma fractions derived from blood plasma with efficacy in treating and/or preventing aging-related conditions such as cognitive disorders. The methods relate to a regimen of pulsed dosing of blood plasma or blood plasma fractions.

Abstract: Methods and compositions for treating and/or preventing aging-related conditions are described. The compositions used in the methods include blood plasma and blood plasma fractions derived from blood plasma with efficacy in treating and/or preventing aging-related conditions such as cognitive disorders. The methods relate to a regimen of pulsed dosing of blood plasma or blood plasma fractions.

Abstract: Methods of improving visual endpoints related to retina-associated disease with CCR3 modulating agents are provided. An example of such an endpoint is visual acuity. Retina-associated diseases upon which visual acuity and other visual endpoints may be improved include retinopathy of prematurity, age-related macular degeneration, central retinal vein occlusion, and diabetic retinopathy.

Abstract: Articles of footwear and methods of making articles of footwear including one or more continuous threads wound around anchor points. The winding of the one or more continuous threads forms a thread pattern that imparts desired characteristics to components of the article of footwear. Thread lines of the thread pattern may be bonded together. In some embodiments, thread lines may be bonded with a bonding layer.

Abstract: Articles of footwear and methods of making articles of footwear including one or more continuous threads wound around anchor points. The winding of the one or more continuous threads forms a thread pattern that imparts desired characteristics to components of the article of footwear. Thread lines of the thread pattern may be bonded together. In some embodiments, thread lines may be bonded with a bonding layer.

Abstract: Methods and compositions for treating and/or preventing aging-related conditions are described. The compositions used in the methods include blood plasma and blood plasma fractions derived from blood plasma with efficacy in treating and/or preventing aging-related conditions such as cognitive disorders. The methods relate to a regimen of pulsed dosing of blood plasma or blood plasma fractions.

Abstract: Articles of footwear and methods of making articles of footwear including one or more continuous threads wound around anchor points. The winding of the one or more continuous threads forms a thread pattern that imparts desired characteristics to components of the article of footwear. Thread lines of the thread pattern may be bonded together. In some embodiments, thread lines may be bonded with a bonding layer.

Abstract: Described herein is a system and method for generic product wiring in a cloud environment. In accordance with an embodiment, a virtual assembly builder can be used to virtualize installed components in a reference environment, and then deploy those components into another destination environment. A user can capture the configuration and binaries of software components into software appliance artifacts, which can be grouped and their relationships defined as software assembly artifacts. In accordance with an embodiment, a generic product introspector plugin allows users to specify at introspection, during creation of a virtual assembly, one or more metadata properties to be exposed for editing and configuration by scripts, during a subsequent rehydration of the virtual assembly. The properties exposed for editing and configuration by scripts can be used during instantiation of an instance of the assembly to define one or more inputs and outputs for the instance.

Abstract: A stateful or stateless cookie operations server machine can provide real-time, actionable, user-specific tracking abilities in the collection of impressions and user interactions with a company's digital properties. The client-side code (e.g., in a web browser) may request an element configured with parameters and a hyperlink (e.g., URL) that causes parameters to be sent to a remote server. The remote server may process the parameters and perform various operations based on the parameters. Mathematical and/or other operations may be performed using the parameters. The remote server may retrieve a configuration corresponding to the request. The remote server may generate or transform content, based on the configuration. The remote server may transmit the transformed content.

Abstract: A stateless cookie operations server machine can provide real-time, actionable, user-specific tracking abilities in the collection of impressions and user interactions with a company's digital properties. The client-side code (e.g., in a web browser) may load an image element configured with parameters and a hyperlink (e.g., URL) that causes name-value pairs to be sent as parameters, along with a cookie data file, to a remote server. The remote server may process the parameters and perform operations based on both the value and the name of the name-value pairs. Mathematical and/or other operations may be performed on the parameters and the results saved into the appropriate cookie data file. The server sends the update cookie data file and any requested content (e.g., a transparent image pixel, or other information) back to the client-side device.

Abstract: Described herein is a system and method for generic product wiring in a cloud environment. In accordance with an embodiment, a virtual assembly builder can be used to virtualize installed components in a reference environment, and then deploy those components into another destination environment. A user can capture the configuration and binaries of software components into software appliance artifacts, which can be grouped and their relationships defined as software assembly artifacts. In accordance with an embodiment, a generic product introspector plugin allows users to specify at introspection, during creation of a virtual assembly, one or more metadata properties to be exposed for editing and configuration by scripts, during a subsequent rehydration of the virtual assembly. The properties exposed for editing and configuration by scripts can be used during instantiation of an instance of the assembly to define one or more inputs and outputs for the instance.

Abstract: The present invention discloses a bowling/pitching game that can be played virtually anywhere a substantially flat surface can be found and is enjoyable for adults as well as children. The playing field includes a distance marker and a scoring goal comprised of an outer scoring area and an inner scoring area. The goal also includes a game pole called the OOnagi™ pole and an object ball called an OOnagi™ ball, which sits on top of the OOnagi™ pole. While standing at the distance marker, the players pitch or bowl their balls called chuckers at the scoring goal. Scores are calculated according to the placement of the chuckers and OOnagi™ ball in the scoring goal.

Abstract: The present invention discloses a bowling/pitching game that can be played virtually anywhere a substantially flat surface can be found and is enjoyable for adults as well as children. The playing field includes a distance marker and a scoring goal comprised of an outer scoring area and an inner scoring area. The goal also includes a game pole called the OOnagi™ pole and an object ball called an OOnagi™ ball, which sits on top of the OOnagi™ pole. While standing at the distance marker, the players pitch or bowl their balls called chuckers at the scoring goal. Scores are calculated according to the placement of the chuckers and OOnagi™ ball in the scoring goal.