Abstract: Methods for non-invasive retrieval of viable (i.e., able to be fertilized) oocytes from the uterus via a combination of unique ovarian stimulation and uterine lavage technology. These methods may eliminate the need for an invasive surgical procedure. Embodiments include the use of a novel hormonal protocol, including the use of injectable gonadotropins, to induce the release of immature oocytes from the ovaries of a patient. The immature oocytes mature as they transit the fallopian tubes such that mature, viable oocytes may be collected from the uterus via a uterine lavage procedure. Further embodiments include the use of a novel hormonal protocol, including the administration of Prostaglandins, Estradiol, and/or Progesterone Blockers, to accelerate transport of oocytes through the fallopian tubes.

Abstract: Uterine lavage devices and methods are described. A uterine lavage catheter device for recovering oocytes or blastocysts from a human uterus may include a seal element configured to provide a sealing surface against the exterior cervical ostium, a supply lumen extending from the seal element and configured to supply lavage fluid, a nozzle configured to generate a spray pattern, and a return lumen.