Patents by Inventor Sam Possemiers
Sam Possemiers has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11633440Abstract: The disclosure relates to a mixture of bacteria belonging to at least six or seven different and specific bacterial species preferably for use in preventing or treating gastro-intestinal disorders. Preferably, the mixture of bacteria is grown together in a fermenter prior to administering the mixture to a subject in order to prevent or treat the disorder.Type: GrantFiled: October 3, 2022Date of Patent: April 25, 2023Inventors: Sam Possemiers, Massimo Marzorati, Tom Van De Wiele, Ilse Scheirlinck, Pieter Van Den Abeele, Selin Bolca, Davide Gottardi
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Patent number: 11596658Abstract: The disclosure relates to a mixture of bacteria belonging to at least six or seven different and specific bacterial species preferably for use in preventing or treating gastro-intestinal disorders. Preferably, the mixture of bacteria is grown together in a fermenter prior to administering the mixture to a subject in order to prevent or treat the disorder.Type: GrantFiled: October 3, 2022Date of Patent: March 7, 2023Inventors: Sam Possemiers, Massimo Marzorati, Tom Van De Wiele, Ilse Scheirlinck, Pieter Van Den Abeele, Selin Bolca, Davide Gottardi
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Patent number: 11557226Abstract: Gastrointestinal tract simulation system and compartment therefor. The compartment comprising a vessel having an open top surrounded by a peripheral edge portion and an air-tight lid system configured to be placed onto the peripheral edge portion. The lid system comprises a body with a plurality of passageways extending through the body and providing access to the interior of the vessel, the plurality of passageways comprising passageways for fluid transfer tubes and passageways for mounting at least one sensor component. The lid system is provided with releasable sealing elements for sealing the plurality of passageways and at least one pressing element which is common to at least a number of the sealing elements and configured for applying pressure to each of the respective sealing elements to effect the sealing of the respective passageways.Type: GrantFiled: June 6, 2018Date of Patent: January 17, 2023Assignee: PRODIGEST BVBAInventors: Louis-Philippe Mascart, Massimo Marzorati, Tim Windels, Sam Possemiers, Pieter Van Den Abbeele
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Patent number: 11491196Abstract: The disclosure relates to a mixture of bacteria belonging to at least six or seven different and specific bacterial species preferably for use in preventing or treating gastro-intestinal disorders. Preferably, the mixture of bacteria is grown together in a fermenter prior to administering the mixture to a subject in order to prevent or treat the disorder.Type: GrantFiled: October 15, 2021Date of Patent: November 8, 2022Assignees: Universiteit Gent, Microbial Resource Management Health NV MRM HealthInventors: Sam Possemiers, Massimo Marzorati, Tom Van de Wiele, Ilse Scheirlinck, Pieter Van den Abeele, Selin Bolca, Davide Gottardi
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Patent number: 11324717Abstract: The present invention relates to the use of carotenoids, in particular a microbial carotenoid compound of formula I, such as methyl-glycosyl-apo-8?-lycopenoate or glycosyl-apo-8?-lycopene, for restoring and/or maintaining a health-beneficial gut microbial composition in a subject. The invention further provides the use of said compound in the treatment of disorders associated with a disturbed intestinal barrier integrity, such as for example irritable bowel syndrome. Further, a compound or composition comprising a microbial carotenoid compound is disclosed for use in the prevention and/or treatment of disorders associated with disturbed intestinal barrier integrity.Type: GrantFiled: June 22, 2017Date of Patent: May 10, 2022Assignee: Microbial Research Management Health NVInventors: Sam Possemiers, Cindy Duysburgh, Iris Pinheiro, Selin Bolca, Pieter Van Den Abbeele, Massimo Marzorati
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Patent number: 11304967Abstract: The present invention provides the use of a compound of formula I, and compositions comprising such a compound, for improving power output and/or oxygen efficiency in a subject.Type: GrantFiled: February 11, 2016Date of Patent: April 19, 2022Assignee: BIOACTOR BVInventors: Antonie Johannes Van Der Saag, Sam Possemiers
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Publication number: 20210353694Abstract: The disclosure relates to a mixture of bacteria belonging to at least six or seven different and specific bacterial species preferably for use in preventing or treating gastro-intestinal disorders. Preferably, the mixture of bacteria is grown together in a fermenter prior to administering the mixture to a subject in order to prevent or treat the disorder.Type: ApplicationFiled: July 27, 2021Publication date: November 18, 2021Inventors: Sam Possemiers, Massimo Marzorati, Tom Van De Wiele, Ilse Scheirlinck, Pieter Van Den Abeele, Selin Bolca, Davide Gottardi
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Patent number: 11141420Abstract: The present invention relates to compounds of formula (I), such as hesperitin-7-rutinoside 2S, for use in the treatment of visceral hypersensitivity. Compounds and compositions of the invention are particularly useful in the treatment of visceral hypersensitivity in a subject having irritable bowel syndrome or age-associated low grade systemic inflammation of the gut, but lacking spasmodic intestinal contractions.Type: GrantFiled: February 23, 2018Date of Patent: October 12, 2021Assignee: BioActor BVInventors: Antonie Johannes Van der Saag, Bouke Salden, Sam Possemiers, Yala Stevens
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Patent number: 11096971Abstract: The present disclosure relates to a mixture of bacteria belonging to at least six or seven different and specific bacterial species preferably for use in preventing or treating gastro-intestinal disorders. Preferably, the mixture of bacteria are grown together in a fermenter prior to administering the mixture to a subject in order to prevent or treat the disorder.Type: GrantFiled: February 3, 2017Date of Patent: August 24, 2021Assignees: UNIVERSllEll GENT, MICROBIAL RESOURCE MANAGEMENT HEALInventors: Sam Possemiers, Massimo Marzorati, Tom Van De Wiele, Ilse Scheirlinck, Pieter Van Den Abeele, Selin Bolca, Davide Gottardi
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Publication number: 20200230165Abstract: The present invention relates to compounds of formula (I), such as hesperitin-7-rutinoside 2S, for use in the treatment of visceral hypersensitivity. Compounds and compositions of the invention are particularly useful in the treatment of visceral hyper-sensitivity in a subject having irritable bowel syndrome or age-associated low grade systemic inflammation of the gut, but lacking spasmodic intestinal contractions.Type: ApplicationFiled: February 23, 2018Publication date: July 23, 2020Applicant: BioActor BVInventors: Antonie Johannes Van der Saag, Bouke Salden, Sam Possemiers, Yala Stevens
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Publication number: 20190209516Abstract: The present invention relates to the use of carotenoids, in particular a microbial carotenoid compound of formula I, such as methyl-glycosyl-apo-8?-lycopenoate or glycosyl-apo-8?-lycopene, for restoring and/or maintaining a health-beneficial gut microbial composition in a subject. The invention further provides the use of said compound in the treatment of disorders associated with a disturbed intestinal barrier integrity, such as for example irritable bowel syndrome. Further, a compound or composition comprising a microbial carotenoid compound is disclosed for use in the prevention and/or treatment of disorders associated with disturbed intestinal barrier integrity.Type: ApplicationFiled: June 22, 2017Publication date: July 11, 2019Applicant: ProDigest BVBAInventors: Sam Possemiers, Cindy Duysburgh, Iris Pinheiro, Selin Bolca, Pieter Van Den Abbeele, Massimo Marzorati
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Patent number: 8709764Abstract: The invention discloses the demethylation of 5-methoxyflavonoids by bacterial enzymes, the use of these enzymes in the production of phytoestrogens in vitro, and in pharmaceutical compositions in combination with a source of methylated 5-methoxyprenylflavonoids.Type: GrantFiled: March 27, 2006Date of Patent: April 29, 2014Assignee: Universiteit GentInventors: Sam Possemiers, Willy Verstraete, Arne Heyerick, Denis De Keukeleire
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Patent number: 8703479Abstract: A method is provided for co-culturing viable cells and microorganisms for at least 48 hours in which an adhesion module is provided including a basal compartment and a luminal compartment separated by a semi-permeable membrane, and a continuous or semi-continuous flow of fresh medium is applied to the basal compartment.Type: GrantFiled: April 12, 2013Date of Patent: April 22, 2014Assignee: Universiteit GentInventors: Massimo Marzorati, Sam Possemiers, Pieter Van Den Abbeele, Tom Van De Wiele, Barbara Vanhoecke, Willy Verstraete
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Patent number: 8465788Abstract: The present invention is directed to a particular arabinoxylan (“AX”) preparation and the finding that this preparation has a beneficial effect on the organization of the intestinal microbial community in the lumen and in particular at the site of the gut mucosa, where it modulates the barrier function of the intestinal surface, primarily by modulating the mucosa-associated microbial community towards a relative increase of health beneficial bacteria, such as bifidobacteria and lactobacilli. It is accordingly a first aspect of the present invention to provide said arabinoxylan preparation characterized in comprising isolated water-soluble arabinoxylans and the use thereof to improve functioning (e.g. barrier function) of the intestinal epithelium.Type: GrantFiled: August 18, 2009Date of Patent: June 18, 2013Assignee: BioActor B.V.Inventors: Peter Frank Ekhart, Hans Van Der Saag, Sam Possemiers, Pieter Van Den Abbeele, Tom Van De Wiele, Audrey Martine Neyrinck, Nathalie Maria Nelly Delzenne, Patrice D Cani
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Publication number: 20120230955Abstract: The present invention is directed to a particular arabinoxylan (“AX”) preparation and the finding that this preparation has a beneficial effect on the organization of the intestinal microbial community in the lumen and in particular at the site of the gut mucosa, where it modulates the barrier function of the intestinal surface, primarily by modulating the mucosa-associated microbial community towards a relative increase of health beneficial bacteria, such as bifidobacteria and lactobacilli. It is accordingly a first aspect of the present invention to provide said arabinoxylan preparation characterized in comprising isolated water-soluble arabinoxylans and the use thereof to improve functioning (e.g. barrier function) of the intestinal epithelium.Type: ApplicationFiled: August 18, 2009Publication date: September 13, 2012Applicant: BioActor bvbaInventors: Peter Frank Ekhart, Hans Van De Saag, Sam Possemiers, Pieter Van Den Abbeele, Tom Van De Wiele, Audrey Martine Neyrinck, Nathalie Maria Nelly Delzenne, Patrice D. Cani
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Publication number: 20120058551Abstract: The present invention relates to in vitro adhesion modules that allow growth, stabilization and study of microbial communities that adhere to and colonize host-related surfaces, that mimic transport of chemical compounds across epithelial surfaces and simulate host-microorganism interactions and adaptation. It includes the provision of micromolar amounts of oxygen via the basal side of a mucus layer towards the adhered microorganisms thus establishing the microaerophilic conditions prevailing at the base of a biofilm. It can also include cells, simulating the host, in a chamber on the basal side of a functional layer comprising said mucus layer. The adhesion module of the present invention can be placed between the different compartments of the SHIME—the Simulator of the Human Intestinal Microbial Ecosystem. An extension of the SHIME is made where the duodenum, jejunum and ileum are separately mimicked.Type: ApplicationFiled: April 14, 2010Publication date: March 8, 2012Applicant: UNIVERSITEIT GENTInventors: Massimo Marzorati, Sam Possemiers, Pieter Van Den Abbeele, Tom Van De Wiele, Barbara Vanhoecke, Willy Verstraete
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Publication number: 20090130724Abstract: The invention discloses the demethylation of 5-methoxyflavonoids by bacterial enzymes, the use of these enzymes in the production of phytoestrogens in vitro, and in pharmaceutical compositions in combination with a source of methylated 5-methoxyprenylflavonoids.Type: ApplicationFiled: March 27, 2006Publication date: May 21, 2009Inventors: Sam Possemiers, Willy Verstraete, Arne Heyerick, Denis De Keukeleire