Patents by Inventor Sam S. Lee
Sam S. Lee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10464914Abstract: The present invention provides, among other things, compounds represented by the general Formula I: (I) and pharmaceutically acceptable salts thereof, wherein L and A (and further substituents) are as defined in classes and subclasses herein and compositions (e.g., pharmaceutical compositions) comprising such compounds, which compounds are useful as inhibitors of hepatitis C virus polymerase, and thus are useful, for example, as medicaments for the treatment of HCV infection.Type: GrantFiled: March 23, 2016Date of Patent: November 5, 2019Assignee: COCRYSTAL PHARMA, INC.Inventors: Irina C. Jacobson, Michael D. Feese, Sam S. Lee
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Patent number: 10426762Abstract: The present invention provides, among other things, compounds represented by the general Formula I: and pharmaceutically acceptable salts thereof, wherein X, Y, R2, and R3 are as defined in classes and subclasses herein and compositions (e.g., pharmaceutical compositions) comprising such compounds, which compounds are useful as inhibitors of hepatitis C virus polymerase, and thus are useful, for example, as medicaments for the treatment of HCV infection.Type: GrantFiled: June 9, 2017Date of Patent: October 1, 2019Assignee: COCRYSTAL PHARMA, INC.Inventors: Sam S. Lee, Wang Shen, Xiaoling Zheng, Irina C. Jacobson
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Publication number: 20180050998Abstract: The present invention provides, among other things, compounds represented by the general Formula I: (I) and pharmaceutically acceptable salts thereof, wherein L and A (and further substituents) are as defined in classes and subclasses herein and compositions (e.g., pharmaceutical compositions) comprising such compounds, which compounds are useful as inhibitors of hepatitis C virus polymerase, and thus are useful, for example, as medicaments for the treatment of HCV infection.Type: ApplicationFiled: March 23, 2016Publication date: February 22, 2018Inventors: Irina C. Jacobson, Michael D. Feese, Sam S. Lee
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Publication number: 20170273962Abstract: The present invention provides, among other things, compounds represented by the general Formula I: and pharmaceutically acceptable salts thereof, wherein X, Y, R2, and R3 are as defined in classes and subclasses herein and compositions (e.g., pharmaceutical compositions) comprising such compounds, which compounds are useful as inhibitors of hepatitis C virus polymerase, and thus are useful, for example, as medicaments for the treatment of HCV infection.Type: ApplicationFiled: June 9, 2017Publication date: September 28, 2017Inventors: Sam S. Lee, Wang Shen, Xiaoling Zheng, Irina C. Jacobson
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Patent number: 5955396Abstract: A solid, hydrocarbon-insoluble, olefin-polymerization catalyst component having substantially uniform particles useful in polymerizing olefins is formed by:reacting a magnesium-containing compound with carbon dioxide or sulfur dioxide;forming a two-phase mixture of the resulting magnesium-containing compound with a suitable liquid hydrocarbon-miscible phase and a suitable polar solvent phase;forming particles by adding the two-phase mixture after vigorous agitation to a liquid hydrocarbon; andcontacting the formed particles at least once with a transition metal halide in the presence of an electron donor.Type: GrantFiled: July 17, 1996Date of Patent: September 21, 1999Assignee: BP Amoco CorporationInventors: Sam S. Lee, Mary K. Trost, Steven A. Cohen
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Patent number: 5224869Abstract: A slidable door apparatus for a socket of a computer includes a movable plate, a slidable door, a resilient assembly, two sliding ribs and two sliding grooves. The computer includes a lower casing and a middle casing. The lower casing has a socket opening formed through a side wall thereof and includes a recess formed in the side wall of the lower casing beside the socket opening. The movable plate is mounted movably between the lower casing and the middle casing. The slidable door is mounted slidably between the lower casing and the middle casing in alignment with the movable plate so as to cover the socket opening. The resilient assembly is interposed between the movable plate and the side wall of the lower casing. The two guiding grooves are respectively formed in the upper portion and the lower portion of the slidable door.Type: GrantFiled: November 9, 1992Date of Patent: July 6, 1993Assignee: Samtech CorporationInventor: Sam S. Lee
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Patent number: 5223466Abstract: A process for making a magnesium-containing supported titanium-containing, alpha-olefin polymerization or co-polymerization catalyst or catalyst component having a large particle size, semi-spherical particle shape and high resistance to attrition.Type: GrantFiled: March 20, 1992Date of Patent: June 29, 1993Assignee: Amoco CorporationInventors: Sam S. Lee, Nicholas M. Karayannis
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Patent number: 5124297Abstract: A catalyst or catalyst component for the polymerization of copolymerization of alpha-olefins, which is formed by a process comprising forming a solution of a magnesium-containing species in a liquid comprising at least one alcohol.Type: GrantFiled: December 7, 1990Date of Patent: June 23, 1992Assignee: Amoco CorporationInventors: Gregory G. Arzoumanidis, Mark A. Drezdzon, Sam S. Lee
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Patent number: 5013702Abstract: A solid hydrocarbon-insoluble, alpha-olefin polymerization catalyst component with superior activity, stereospecificity and morphology characteristics comprises the product formed by (A) forming a solution of a magnesium-containing species from a magnesium carbonate or a magnesium carboxylate; (B) precipitating solid particles from such magnesium-containing solution by treatment with a transition metal halide and an organosilane; (C) reprecipitating such solid particles from a mixture containing a cyclic ether; and (D) treating the reprecipitated particles with a transition metal compound and an electron donor.Type: GrantFiled: November 9, 1989Date of Patent: May 7, 1991Assignee: Amoco CorporationInventors: Gregory G. Arzoumanidis, Nicholas M. Karayannis, Habet M. Khelghatian, Sam S. Lee, Bryce V. Johnson
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Patent number: 4988656Abstract: A solid hydrocarbon-insoluble, alpha-olefin polymerization catalyst component with superior activity, stereospecificity and morphology characteristics comprises the product formed by (A) forming a solution of a magnesium-containing species from a magnesium carbonte or a magnesium carboxylate; (B) precipitating solid particles from such magnesium-containing solution by treatment with a transition metal halide and an organosilane; (C) reprecipitating such solid particles from a mixture containing a cyclic ether; and (D) treating the reprecipitated particles with a transition metal compound and an electron donor.Type: GrantFiled: May 12, 1989Date of Patent: January 29, 1991Assignee: Amoco CorporationInventors: Gregory G. Arzoumanidis, Nicholas M. Karayannis, Habet M. Khelghatian, Sam S. Lee, Bryce V. Johnson
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Patent number: 4946816Abstract: In a solid hydrocarbon-insoluble, alpha-olefin polymerization catalyst component with superior activity, stereospecificity and morphology characteristics comprising the product formed by (A) forming a solution of a magnesium-containing species from a magnesium alkyl (or hydrocarbyl) carbonate or a magnesium carboxylate; (B) precipitating solid particles from such magnesium-containing toluene-based solvent by treatment with a transition metal halide and an organosilane; (C) reprecipitating such solid particles from a mixture containing a cyclic either; and (D) treating the reprecipitated particles with a transition metal compound and an electron donor, the morphology of such component is modified by incorporating a morphology-affecting amount of C.sub.8 -C.sub.10 aromatics within the toluene-based solvent in Step B, Step A, in Step C prior to addition of ether, or combinations thereof.Type: GrantFiled: August 21, 1989Date of Patent: August 7, 1990Assignee: Amoco CorporationInventors: Steven A. Cohen, Gregory G. Arzoumanidis, Nicholas M. Karayannis, Habet M. Khelghatian, Sam S. Lee
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Patent number: 4912608Abstract: A flickering ornamental device includes a combination of a fundamental unit and a locket structure wherein the fundamental unit is composed of a mounting seat and a PC board, having a flickering circuit and a lamp unit electrically disposed therein for effecting intermittent flickering operations therewith; while said locket structure is composed of a case frame, which has a variable outer appearance adapted for ornamental purposes, a screen member with letters or figures captioned thereon, a reflecting plate and a base member provided in conjunction with the mounting seat and the PC board; whereby, when the flickering circuit is energized, intermittent flickering of the letters or figures will be effected in the locket structure.Type: GrantFiled: August 24, 1989Date of Patent: March 27, 1990Inventor: Sam S. Lee
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Patent number: 4894757Abstract: The present invention provides an illuminating apparatus for ornamental elements such as in an illuminated necklace, an illuminated belt or the like, which includes a plurality of lamps to illuminate more than one lamp housing which simulates a pendant or the like. A battery assembly is provided in one of the lamp housings to power the circuit of the illuminating apparatus.Type: GrantFiled: August 22, 1988Date of Patent: January 16, 1990Inventors: John D. Frusha, Sam S. Lee
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Patent number: 4866022Abstract: A solid hydrocarbon-insoluble, alpha-olefin polymerization catalyst component with superior activity, stereospecificity and morphology characteristics comprises the product formed by (A) forming a solution of a magnesium-containing species from a magnesium carbonate or a magnesium carboxylate; (B) precipitating solid particles from such magnesium-containing solution by treatment with a transition metal halide and an organosilane; (C) reprecipitating such solid particles from a mixture containing a cyclic ether; and (D) treating the reprecipitated particles with a transition metal compound and an electron donor.Type: GrantFiled: April 25, 1988Date of Patent: September 12, 1989Assignee: Amoco CorporationInventors: Gregory G. Arzoumanidis, Nicholas M. Karayannis, Habet M. Khelghatian, Sam S. Lee, Bryce V. Johnson
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Patent number: 4657883Abstract: An olefin polymerization catalyst component comprises an organoaluminum-reduced titanium trihalide on which a pretreatment amount of olefin polymer has been placed complexed with an alkyl aliphatic carboxylic acid ester containing 7 to 22 carbon atoms having a structure:R--CO.sub.2 R'wherein R' is an alkyl group containing 3 to about 8 carbon atoms and R is an alkyl group containing 3 to 17 carbon atoms, and treated with a Lewis acid, a chlorocarbon or an haloalkylchlorosilane.Type: GrantFiled: October 7, 1985Date of Patent: April 14, 1987Assignee: Amoco CorporationInventors: Gregory G. Arzoumanidis, Sam S. Lee, Thomas E. Wolff, Linda Ornellas
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Patent number: 4612299Abstract: Composition comprising a transition metal component and magnesium carboxylate prepared by reacting a solution of hydrocarbyl magnesium compound with carbon dioxide to precipitate a magnesium carboxylate and reacting magnesium carboxylate with transition metal component.Type: GrantFiled: June 6, 1985Date of Patent: September 16, 1986Assignee: Amoco CorporationInventors: Gregory G. Arzoumanidis, Habet M. Khelghatian, Sam S. Lee
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Patent number: 4579836Abstract: An exhaustively prepolymerized supported olefin polymerization catalyst component comprises solid, hydrocarbon-insoluble, magnesium-containing, titanium-containing catalyst particles which have been contacted with an olefin monomer and an organo-aluminum co-catalyst under exhaustive prepolymerization conditions at an Al/Ti atomic ratio such that the weight of prepolymer formed is less than 10 times the weight of such catalyst particles and the resulting prepolymerized catalyst particles essentially are inactive to further polymerization.Type: GrantFiled: May 22, 1985Date of Patent: April 1, 1986Assignee: Amoco CorporationInventors: Gregory G. Arzoumanidis, Sam S. Lee, Benjamin S. Tovrog
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Patent number: 4540679Abstract: Composition comprising a transition metal component and magnesium hydrocarbyl carbonate. Composition can be prepared by reacting suspension of magnesium alcoholate with carbon dioxide to form a magnesium hydrocarbyl carbonate and reacting magnesium hydrocarbyl carbonate with transition metal component. When the suspending liquid comprises an alcohol, the magnesium hydrocarbyl carbonate dissolves and is subsequently precipitated with an antisolvent comprising metal alkyl or transition metal halide. When the suspending liquid is substantially free of alcohol, the magnesium hydrocarbyl carbonate suspension is reacted with metal alkyl and transition metal compound.Type: GrantFiled: March 23, 1984Date of Patent: September 10, 1985Assignee: Amoco CorporationInventors: Gregory G. Arzoumanidis, Sam S. Lee
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Patent number: 4422956Abstract: A titanium-containing olefin polymerization catalyst component comprises a titanium-containing component formed by reducing titanium tetrachloride with an organoaluminum compound, optionally contacting the resulting reduced solid with a pretreatment amount of alpha-olefin monomer under polymerization conditions, and reacting the resulting product with a Lewis base complexing agent and a haloalkylchlorosilane.Type: GrantFiled: May 14, 1982Date of Patent: December 27, 1983Assignee: Standard Oil Company (Indiana)Inventors: Gregory G. Arzoumanidis, Sam S. Lee
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Patent number: 4324693Abstract: In a method to produce an alpha-olefin polymerization catalyst comprising reducing titanium tetrachloride with an aluminum alkyl, contacting the resulting reduced solid with a pretreatment amount of alpha-olefin monomer under polymerization conditions and reacting the resulting product with a Lewis base complexing agent and additional titanium tetrachloride, the improvement comprising reacting the Lewis base complexing agent in a molar ratio to the reduced titanium compound of greater than 1.15 to 1.Type: GrantFiled: October 10, 1980Date of Patent: April 13, 1982Assignee: Standard Oil Company (Indiana)Inventors: Gregory G. Arzoumanidis, Sam S. Lee