Patents by Inventor Sam S. Lee

Sam S. Lee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10464914
    Abstract: The present invention provides, among other things, compounds represented by the general Formula I: (I) and pharmaceutically acceptable salts thereof, wherein L and A (and further substituents) are as defined in classes and subclasses herein and compositions (e.g., pharmaceutical compositions) comprising such compounds, which compounds are useful as inhibitors of hepatitis C virus polymerase, and thus are useful, for example, as medicaments for the treatment of HCV infection.
    Type: Grant
    Filed: March 23, 2016
    Date of Patent: November 5, 2019
    Assignee: COCRYSTAL PHARMA, INC.
    Inventors: Irina C. Jacobson, Michael D. Feese, Sam S. Lee
  • Patent number: 10426762
    Abstract: The present invention provides, among other things, compounds represented by the general Formula I: and pharmaceutically acceptable salts thereof, wherein X, Y, R2, and R3 are as defined in classes and subclasses herein and compositions (e.g., pharmaceutical compositions) comprising such compounds, which compounds are useful as inhibitors of hepatitis C virus polymerase, and thus are useful, for example, as medicaments for the treatment of HCV infection.
    Type: Grant
    Filed: June 9, 2017
    Date of Patent: October 1, 2019
    Assignee: COCRYSTAL PHARMA, INC.
    Inventors: Sam S. Lee, Wang Shen, Xiaoling Zheng, Irina C. Jacobson
  • Publication number: 20180050998
    Abstract: The present invention provides, among other things, compounds represented by the general Formula I: (I) and pharmaceutically acceptable salts thereof, wherein L and A (and further substituents) are as defined in classes and subclasses herein and compositions (e.g., pharmaceutical compositions) comprising such compounds, which compounds are useful as inhibitors of hepatitis C virus polymerase, and thus are useful, for example, as medicaments for the treatment of HCV infection.
    Type: Application
    Filed: March 23, 2016
    Publication date: February 22, 2018
    Inventors: Irina C. Jacobson, Michael D. Feese, Sam S. Lee
  • Publication number: 20170273962
    Abstract: The present invention provides, among other things, compounds represented by the general Formula I: and pharmaceutically acceptable salts thereof, wherein X, Y, R2, and R3 are as defined in classes and subclasses herein and compositions (e.g., pharmaceutical compositions) comprising such compounds, which compounds are useful as inhibitors of hepatitis C virus polymerase, and thus are useful, for example, as medicaments for the treatment of HCV infection.
    Type: Application
    Filed: June 9, 2017
    Publication date: September 28, 2017
    Inventors: Sam S. Lee, Wang Shen, Xiaoling Zheng, Irina C. Jacobson
  • Patent number: 5955396
    Abstract: A solid, hydrocarbon-insoluble, olefin-polymerization catalyst component having substantially uniform particles useful in polymerizing olefins is formed by:reacting a magnesium-containing compound with carbon dioxide or sulfur dioxide;forming a two-phase mixture of the resulting magnesium-containing compound with a suitable liquid hydrocarbon-miscible phase and a suitable polar solvent phase;forming particles by adding the two-phase mixture after vigorous agitation to a liquid hydrocarbon; andcontacting the formed particles at least once with a transition metal halide in the presence of an electron donor.
    Type: Grant
    Filed: July 17, 1996
    Date of Patent: September 21, 1999
    Assignee: BP Amoco Corporation
    Inventors: Sam S. Lee, Mary K. Trost, Steven A. Cohen
  • Patent number: 5224869
    Abstract: A slidable door apparatus for a socket of a computer includes a movable plate, a slidable door, a resilient assembly, two sliding ribs and two sliding grooves. The computer includes a lower casing and a middle casing. The lower casing has a socket opening formed through a side wall thereof and includes a recess formed in the side wall of the lower casing beside the socket opening. The movable plate is mounted movably between the lower casing and the middle casing. The slidable door is mounted slidably between the lower casing and the middle casing in alignment with the movable plate so as to cover the socket opening. The resilient assembly is interposed between the movable plate and the side wall of the lower casing. The two guiding grooves are respectively formed in the upper portion and the lower portion of the slidable door.
    Type: Grant
    Filed: November 9, 1992
    Date of Patent: July 6, 1993
    Assignee: Samtech Corporation
    Inventor: Sam S. Lee
  • Patent number: 5223466
    Abstract: A process for making a magnesium-containing supported titanium-containing, alpha-olefin polymerization or co-polymerization catalyst or catalyst component having a large particle size, semi-spherical particle shape and high resistance to attrition.
    Type: Grant
    Filed: March 20, 1992
    Date of Patent: June 29, 1993
    Assignee: Amoco Corporation
    Inventors: Sam S. Lee, Nicholas M. Karayannis
  • Patent number: 5124297
    Abstract: A catalyst or catalyst component for the polymerization of copolymerization of alpha-olefins, which is formed by a process comprising forming a solution of a magnesium-containing species in a liquid comprising at least one alcohol.
    Type: Grant
    Filed: December 7, 1990
    Date of Patent: June 23, 1992
    Assignee: Amoco Corporation
    Inventors: Gregory G. Arzoumanidis, Mark A. Drezdzon, Sam S. Lee
  • Patent number: 5013702
    Abstract: A solid hydrocarbon-insoluble, alpha-olefin polymerization catalyst component with superior activity, stereospecificity and morphology characteristics comprises the product formed by (A) forming a solution of a magnesium-containing species from a magnesium carbonate or a magnesium carboxylate; (B) precipitating solid particles from such magnesium-containing solution by treatment with a transition metal halide and an organosilane; (C) reprecipitating such solid particles from a mixture containing a cyclic ether; and (D) treating the reprecipitated particles with a transition metal compound and an electron donor.
    Type: Grant
    Filed: November 9, 1989
    Date of Patent: May 7, 1991
    Assignee: Amoco Corporation
    Inventors: Gregory G. Arzoumanidis, Nicholas M. Karayannis, Habet M. Khelghatian, Sam S. Lee, Bryce V. Johnson
  • Patent number: 4988656
    Abstract: A solid hydrocarbon-insoluble, alpha-olefin polymerization catalyst component with superior activity, stereospecificity and morphology characteristics comprises the product formed by (A) forming a solution of a magnesium-containing species from a magnesium carbonte or a magnesium carboxylate; (B) precipitating solid particles from such magnesium-containing solution by treatment with a transition metal halide and an organosilane; (C) reprecipitating such solid particles from a mixture containing a cyclic ether; and (D) treating the reprecipitated particles with a transition metal compound and an electron donor.
    Type: Grant
    Filed: May 12, 1989
    Date of Patent: January 29, 1991
    Assignee: Amoco Corporation
    Inventors: Gregory G. Arzoumanidis, Nicholas M. Karayannis, Habet M. Khelghatian, Sam S. Lee, Bryce V. Johnson
  • Patent number: 4946816
    Abstract: In a solid hydrocarbon-insoluble, alpha-olefin polymerization catalyst component with superior activity, stereospecificity and morphology characteristics comprising the product formed by (A) forming a solution of a magnesium-containing species from a magnesium alkyl (or hydrocarbyl) carbonate or a magnesium carboxylate; (B) precipitating solid particles from such magnesium-containing toluene-based solvent by treatment with a transition metal halide and an organosilane; (C) reprecipitating such solid particles from a mixture containing a cyclic either; and (D) treating the reprecipitated particles with a transition metal compound and an electron donor, the morphology of such component is modified by incorporating a morphology-affecting amount of C.sub.8 -C.sub.10 aromatics within the toluene-based solvent in Step B, Step A, in Step C prior to addition of ether, or combinations thereof.
    Type: Grant
    Filed: August 21, 1989
    Date of Patent: August 7, 1990
    Assignee: Amoco Corporation
    Inventors: Steven A. Cohen, Gregory G. Arzoumanidis, Nicholas M. Karayannis, Habet M. Khelghatian, Sam S. Lee
  • Patent number: 4912608
    Abstract: A flickering ornamental device includes a combination of a fundamental unit and a locket structure wherein the fundamental unit is composed of a mounting seat and a PC board, having a flickering circuit and a lamp unit electrically disposed therein for effecting intermittent flickering operations therewith; while said locket structure is composed of a case frame, which has a variable outer appearance adapted for ornamental purposes, a screen member with letters or figures captioned thereon, a reflecting plate and a base member provided in conjunction with the mounting seat and the PC board; whereby, when the flickering circuit is energized, intermittent flickering of the letters or figures will be effected in the locket structure.
    Type: Grant
    Filed: August 24, 1989
    Date of Patent: March 27, 1990
    Inventor: Sam S. Lee
  • Patent number: 4894757
    Abstract: The present invention provides an illuminating apparatus for ornamental elements such as in an illuminated necklace, an illuminated belt or the like, which includes a plurality of lamps to illuminate more than one lamp housing which simulates a pendant or the like. A battery assembly is provided in one of the lamp housings to power the circuit of the illuminating apparatus.
    Type: Grant
    Filed: August 22, 1988
    Date of Patent: January 16, 1990
    Inventors: John D. Frusha, Sam S. Lee
  • Patent number: 4866022
    Abstract: A solid hydrocarbon-insoluble, alpha-olefin polymerization catalyst component with superior activity, stereospecificity and morphology characteristics comprises the product formed by (A) forming a solution of a magnesium-containing species from a magnesium carbonate or a magnesium carboxylate; (B) precipitating solid particles from such magnesium-containing solution by treatment with a transition metal halide and an organosilane; (C) reprecipitating such solid particles from a mixture containing a cyclic ether; and (D) treating the reprecipitated particles with a transition metal compound and an electron donor.
    Type: Grant
    Filed: April 25, 1988
    Date of Patent: September 12, 1989
    Assignee: Amoco Corporation
    Inventors: Gregory G. Arzoumanidis, Nicholas M. Karayannis, Habet M. Khelghatian, Sam S. Lee, Bryce V. Johnson
  • Patent number: 4657883
    Abstract: An olefin polymerization catalyst component comprises an organoaluminum-reduced titanium trihalide on which a pretreatment amount of olefin polymer has been placed complexed with an alkyl aliphatic carboxylic acid ester containing 7 to 22 carbon atoms having a structure:R--CO.sub.2 R'wherein R' is an alkyl group containing 3 to about 8 carbon atoms and R is an alkyl group containing 3 to 17 carbon atoms, and treated with a Lewis acid, a chlorocarbon or an haloalkylchlorosilane.
    Type: Grant
    Filed: October 7, 1985
    Date of Patent: April 14, 1987
    Assignee: Amoco Corporation
    Inventors: Gregory G. Arzoumanidis, Sam S. Lee, Thomas E. Wolff, Linda Ornellas
  • Patent number: 4612299
    Abstract: Composition comprising a transition metal component and magnesium carboxylate prepared by reacting a solution of hydrocarbyl magnesium compound with carbon dioxide to precipitate a magnesium carboxylate and reacting magnesium carboxylate with transition metal component.
    Type: Grant
    Filed: June 6, 1985
    Date of Patent: September 16, 1986
    Assignee: Amoco Corporation
    Inventors: Gregory G. Arzoumanidis, Habet M. Khelghatian, Sam S. Lee
  • Patent number: 4579836
    Abstract: An exhaustively prepolymerized supported olefin polymerization catalyst component comprises solid, hydrocarbon-insoluble, magnesium-containing, titanium-containing catalyst particles which have been contacted with an olefin monomer and an organo-aluminum co-catalyst under exhaustive prepolymerization conditions at an Al/Ti atomic ratio such that the weight of prepolymer formed is less than 10 times the weight of such catalyst particles and the resulting prepolymerized catalyst particles essentially are inactive to further polymerization.
    Type: Grant
    Filed: May 22, 1985
    Date of Patent: April 1, 1986
    Assignee: Amoco Corporation
    Inventors: Gregory G. Arzoumanidis, Sam S. Lee, Benjamin S. Tovrog
  • Patent number: 4540679
    Abstract: Composition comprising a transition metal component and magnesium hydrocarbyl carbonate. Composition can be prepared by reacting suspension of magnesium alcoholate with carbon dioxide to form a magnesium hydrocarbyl carbonate and reacting magnesium hydrocarbyl carbonate with transition metal component. When the suspending liquid comprises an alcohol, the magnesium hydrocarbyl carbonate dissolves and is subsequently precipitated with an antisolvent comprising metal alkyl or transition metal halide. When the suspending liquid is substantially free of alcohol, the magnesium hydrocarbyl carbonate suspension is reacted with metal alkyl and transition metal compound.
    Type: Grant
    Filed: March 23, 1984
    Date of Patent: September 10, 1985
    Assignee: Amoco Corporation
    Inventors: Gregory G. Arzoumanidis, Sam S. Lee
  • Patent number: 4422956
    Abstract: A titanium-containing olefin polymerization catalyst component comprises a titanium-containing component formed by reducing titanium tetrachloride with an organoaluminum compound, optionally contacting the resulting reduced solid with a pretreatment amount of alpha-olefin monomer under polymerization conditions, and reacting the resulting product with a Lewis base complexing agent and a haloalkylchlorosilane.
    Type: Grant
    Filed: May 14, 1982
    Date of Patent: December 27, 1983
    Assignee: Standard Oil Company (Indiana)
    Inventors: Gregory G. Arzoumanidis, Sam S. Lee
  • Patent number: 4324693
    Abstract: In a method to produce an alpha-olefin polymerization catalyst comprising reducing titanium tetrachloride with an aluminum alkyl, contacting the resulting reduced solid with a pretreatment amount of alpha-olefin monomer under polymerization conditions and reacting the resulting product with a Lewis base complexing agent and additional titanium tetrachloride, the improvement comprising reacting the Lewis base complexing agent in a molar ratio to the reduced titanium compound of greater than 1.15 to 1.
    Type: Grant
    Filed: October 10, 1980
    Date of Patent: April 13, 1982
    Assignee: Standard Oil Company (Indiana)
    Inventors: Gregory G. Arzoumanidis, Sam S. Lee