Abstract: This invention provides an attenuated virus comprising a modified viral genome engineered to containing multiple nucleotide substitutions that reduce the codon pair bias of a virus protein encoding sequence relative to a first host while the codon pair bias relative to a second host is not substantially reduced. In another embodiment, the invention provides an attenuated virus comprising modified viral genome engineered to containing multiple nucleotide substitutions that reduce the codon pair bias of a virus protein-encoding sequence relative to a first host and a second host. The attenuated virus may be used in a vaccine composition for inducing a protective immune response in a subject. The invention also provides a method of synthesizing the attenuated virus.

Abstract: This invention provides an attenuated virus comprising a modified viral genome engineered to containing multiple nucleotide substitutions that reduce the codon pair bias of a virus protein encoding sequence relative to a first host while the codon pair bias relative to a second host is not substantially reduced. In another embodiment, the invention provides an attenuated virus comprising modified viral genome engineered to containing multiple nucleotide substitutions that reduce the codon pair bias of a virus protein-encoding sequence relative to a first host and a second host. The attenuated virus may be used in a vaccine composition for inducing a protective immune response in a subject. The invention also provides a method of synthesizing the attenuated virus.

Abstract: A system and method for loading and playing multimedia information are disclosed. A navigator sends a series of play orders that each play order demands for playing a corresponding multimedia segment. A playing engine demands a loader to provide the corresponding multimedia segment according to related play order. A decoder is used to decode the provided multimedia segment for playback. Each play order may be delivered even the multimedia segment corresponding to its previous play order has not been played completely yet. The information discontinuity disadvantage can be eliminated since there is a smooth multimedia information stream provided for the decoder.

Abstract: A system and method for loading and playing multimedia information are disclosed. A navigator sends a series of play orders that each play order demands for playing a corresponding multimedia segment. A playing engine demands a loader to provide the corresponding multimedia segment according to related play order. A decoder is used to decode the provided multimedia segment for playback. Each play order may be delivered even the multimedia segment corresponding to its previous play order has not been played completely yet. The information discontinuity disadvantage can be eliminated since there is a smooth multimedia information stream provided for the decoder.

Abstract: The present invention discloses a multi-layer software architecture which includes a MPEG application, a plurality of message queues, and a servo software. An optical disc reader is controlled and directed by the servo software in order to read the information on the optical disc. Both the MPEG application and the servo software share at least a common data buffer as the storage of read-out information. In the embodiment, the MPEG application receives information from the servo software for playback by means of the plurality of message queues.

Abstract: The present invention relates to a protection device for a trampoline, wherein the protection device comprises a plurality of support parts, the two ends of each support part being separately installed with an upper half part and a lower half part; and a protection film being installed between two support parts. Finally, the protection device is combined with a trampoline in order to ensure the safety of a person exercising on the trampoline.