Abstract: Described herein are systems, methods, and programming for analyzing and classifying digital pathology images. Some embodiments include receiving whole slide images (WSIs) and dividing each of the WSIs into tiles. For each WSI, a random subset of the tiles may be selected and augmented views of each of the selected tiles may be generated. For each of the selected tiles, a first convolutional neural network (CNN) may be trained to: generate, using a first one of the augmented views corresponding to the selected tile, a first representation of the selected tile, and predict a second representation of the selected tile to be generated by a second CNN, wherein the second representation is generated based on a second one of the augmented views of the selected tile.

Abstract: A method of object recognition trains a convolutional neural network (CNN) with a set of training images, then classifies an image of an object using the trained CNN. A first layer of the CNN is trained by generating a set of first convolutional filters from eigenvectors produced from linear principal component analysis of patches of the training images. The training of each of multiple hidden layers CNN includes generating a set of convolutional filters from a selected subset of eigenvectors produced from linear principal component analysis of patches of an affinity matrix constructed using a set of prior convolutional filters from a prior layer of the CNN, where the affinity matrix represents correlations of feature vectors associated with the prior layer. The last layer of the CNN is trained with a regular classifier by error back-propagation using the training images and labels associated with the training images.

Abstract: A method of object recognition trains a convolutional neural network (CNN) with a set of training images, then classifies an image of an object using the trained CNN. A first layer of the CNN is trained by generating a set of first convolutional filters from eigenvectors produced from linear principal component analysis of patches of the training images. The training of each of multiple hidden layers CNN includes generating a set of convolutional filters from a selected subset of eigenvectors produced from linear principal component analysis of patches of an affinity matrix constructed using a set of prior convolutional filters from a prior layer of the CNN, where the affinity matrix represents correlations of feature vectors associated with the prior layer. The last layer of the CNN is trained with a regular classifier by error back-propagation using the training images and labels associated with the training images.