Abstract: The present disclosure relates to a medical device in the form of a medical guide wire. The medical guide wire can be used in delivering catheters to treatment sites within human vasculature, and can also be configured to simultaneously allow the user to determine the nature of the blockage within human vasculature. The medical guide wire can be used to determine the extent of organization of thrombus by sensing the electrical resistivity across a blockage. The medical guide wire can include a hollow core through which at least two electrical leads run along the partial or full length of the medical guide wire from proximal to distal end of the medical guide wire. The medical guide wire can include two or more sensors at its distal portion and the sensors are separated from each other.