Patents by Inventor Samantha Vellucci

Samantha Vellucci has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Enhancement of nucleic acid polymerization by aromatic compounds
    Patent number: 11970731
    Abstract: The invention relates to compounds, methods and compositions for improving on nucleic acid polymerization, including DNA replication by in vitro primer extension to generate, for example, polymers for nanopore-based single molecule sequencing of a DNA template. A nucleic acid polymerase reaction composition is provided with polymerization enhancement moieties, which allows enhanced DNA polymerase activity with nucleotide analogs, resulting in improved length of primer extension products for sequencing applications.
    Type: Grant
    Filed: December 27, 2018
    Date of Patent: April 30, 2024
    Assignee: Roche Sequencing Solutions, Inc.
    Inventors: Mark Stamatios Kokoris, John Tabone, Melud Nabavi, Aaron Jacobs, Dylan O'Connell, Drew Goodman, Lacey Merrill, Jagadeeswaran Chandrasekar, Kendall Berg, Samantha Vellucci, Jessica Vellucci
  • DPO4 POLYMERASE VARIANTS
    Publication number: 20220186205
    Abstract: Recombinant DPO4-type DNA polymerase variants with amino acid substitutions that confer modified properties upon the polymerase for improved single molecule sequencing applications are provided. Such properties may include enhanced binding and incorporation of bulky nucleotide analog substrates into daughter strands and the like. Also provided are compositions comprising such DPO4 variants and nucleotide analogs, as well as nucleic acids which encode the polymerases with the aforementioned phenotypes.
    Type: Application
    Filed: March 3, 2022
    Publication date: June 16, 2022
    Inventors: Mark Stamatios Kokoris, Marc Prindle, Melud Nabavi, Craig Ostrander, Taylor Lehmann, Samantha Vellucci, Michael Kovarik, Jack Chase, Robert Busam, Miranda Lahman
  • DP04 polymerase variants
    Patent number: 11299725
    Abstract: Recombinant DPO4-type DNA polymerase variants with amino acid substitutions that confer modified properties upon the polymerase for improved single molecule sequencing applications are provided. Such properties may include enhanced binding and incorporation of bulky nucleotide analog substrates into daughter strands and the like. Also provided are compositions comprising such DPO4 variants and nucleotide analogs, as well as nucleic acids which encode the polymerases with the aforementioned phenotypes.
    Type: Grant
    Filed: May 4, 2020
    Date of Patent: April 12, 2022
    Assignee: Stratos Genomics, Inc.
    Inventors: Mark Stamatios Kokoris, Marc Prindle, Melud Nabavi, Craig Ostrander, Taylor Lehmann, Samantha Vellucci, Michael Kovarik, Jack Chase, Robert Busam, Miranda Lahman
  • METHODS, COMPOSITIONS, AND DEVICES FOR SOLID-STATE SYNTEHSIS OF EXPANDABLE POLYMERS FO RUSE IN SINGLE MOLECULE SEQUENCINGS
    Publication number: 20220042075
    Abstract: Methods, compositions and devices for single molecule sequencing are provided, particularly for solid-state synthesis and processing of expandable polymers (e.g., Xpandomers), as well as methods and compositions for producing new expandable polymer constructs that provide more accurate sequence information when passed through a nanopore sensor.
    Type: Application
    Filed: August 17, 2021
    Publication date: February 10, 2022
    Inventors: Lacey Merrill, Marc Prindle, Samantha Vellucci, Jagadeeswaran Chandrasekar, Mark Stamatios Kokoris, Gerson Aguirre, John Tabone, Robert N. McRuer, Michael Lee, Matthew Corning, Greg Thiessen, Salka Keller Barrett, Christian Berrios, Aaron Jacobs, Taylor Lehmann
  • ENHANCEMENT OF NUCLEIC ACID POLYMERIZATION BY AROMATIC COMPOUNDS
    Publication number: 20210062251
    Abstract: The invention relates to compounds, methods and compositions for improving on nucleic acid polymerization, including DNA replication by in vitro primer extension to generate, for example, polymers for nanopore-based single molecule sequencing of a DNA template. A nucleic acid polymerase reaction composition is provided with polymerization enhancement moieties, which allows enhanced DNA polymerase activity with nucleotide analogs, resulting in improved length of primer extension products for sequencing applications.
    Type: Application
    Filed: December 27, 2018
    Publication date: March 4, 2021
    Inventors: Mark Stamatios Kokoris, John Tabone, Melud Nabavi, Aaron Jacobs, Dylan O'Connell, Drew Goodman, Lacey Merrill, Jagadeeswaran Chandrasekar, Kendall Berg, Samantha Vellucci, Jessica Vellucci
  • DP04 POLYMERASE VARIANTS
    Publication number: 20200385701
    Abstract: Recombinant DPO4-type DNA polymerase variants with amino acid substitutions that confer modified properties upon the polymerase for improved single molecule sequencing applications are provided. Such properties may include enhanced binding and incorporation of bulky nucleotide analog substrates into daughter strands and the like. Also provided are compositions comprising such DPO4 variants and nucleotide analogs, as well as nucleic acids which encode the polymerases with the aforementioned phenotypes.
    Type: Application
    Filed: May 4, 2020
    Publication date: December 10, 2020
    Inventors: Mark Stamatios Kokoris, Marc Prindle, Melud Nabavi, Craig Ostrander, Taylor Lehmann, Samantha Vellucci, Michael Kovarik, Jack Chase, Robert Busam, Miranda Lahman
  • DP04 polymerase variants
    Patent number: 10745685
    Abstract: Recombinant DPO4-type DNA polymerase variants with amino acid substitutions that confer modified properties upon the polymerase for improved single molecule sequencing applications are provided. Such properties may include enhanced binding and incorporation of bulky nucleotide analog substrates into daughter strands and the like. Also provided are compositions comprising such DPO4 variants and nucleotide analogs, as well as nucleic acids which encode the polymerases with the aforementioned phenotypes.
    Type: Grant
    Filed: November 11, 2016
    Date of Patent: August 18, 2020
    Assignee: Stratos Genomics, Inc.
    Inventors: Mark Stamatios Kokoris, Marc Prindle, Melud Nabavi, Craig Ostrander, Taylor Lehmann, Samantha Vellucci, Michael Kovarik, Jack Chase, Robert Busam, Miranda Lahman
  • DP04 POLYMERASE VARIANTS
    Publication number: 20190078075
    Abstract: Recombinant DPO4-type DNA polymerase variants with amino acid substitutions that confer modified properties upon the polymerase for improved single molecule sequencing applications are provided. Such properties may include enhanced binding and incorporation of bulky nucleotide analog substrates into daughter strands and the like. Also provided are compositions comprising such DPO4 variants and nucleotide analogs, as well as nucleic acids which encode the polymerases with the aforementioned phenotypes.
    Type: Application
    Filed: November 11, 2016
    Publication date: March 14, 2019
    Inventors: Mark Stamatios Kokoris, Marc Prindle, Melud Nabavi, Craig Ostrander, Taylor Lehmann, Samantha Vellucci, Michael Kovarik, Jack Chase, Robert Busam, Miranda Lahman