Patents by Inventor Sambasivam Ganesh

Sambasivam Ganesh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HISTONE DEACETYLASE INHIBITORS
    Publication number: 20120101099
    Abstract: The disclosure provides compounds of formula I and methods for preparation thereof. The compounds act as inhibitor of histone deacetylase.
    Type: Application
    Filed: July 7, 2010
    Publication date: April 26, 2012
    Applicant: ANTHEM BIOSCIENCES PRIVATE LIMITED
    Inventors: Natesan Selvakumar, Gavara Govinda Rajulu, Annamalai Pazhanimuthu, Sambasivam Ganesh
  • Process for the preparation of amorphous fluvastatin sodium
    Patent number: 8115013
    Abstract: The present invention relates to a novel process for the preparation of the HMG-CoA reductase inhibitor, fluvastatin, more specifically to a process for the preparation of amorphous form of fluvastatin sodium.
    Type: Grant
    Filed: October 5, 2004
    Date of Patent: February 14, 2012
    Assignee: Biocon Limited
    Inventors: Sumithra Srinath, Tom Thomas Puthiaprampil, Ravindra Chandrapa, Sambasivam Ganesh
  • Process for the production of amorphous atorvastatin calcium
    Patent number: 7645888
    Abstract: A novel process of the preparation of amorphous atorvastatin calcium starting from a compound of Formula (II).
    Type: Grant
    Filed: August 27, 2004
    Date of Patent: January 12, 2010
    Assignee: Biocon Limited
    Inventors: Sumithra Srinath, Joy Matthew, Tom Thomas Puthiaprampil, Sambasivam Ganesh
  • Process for the preparation of tert-butyl 6-cyano-5-hydroxy-3-oxohexanoate
    Patent number: 7557238
    Abstract: In one aspect, the present invention provides a novel process for the preparation of tert-butyl 6-cyano-5-hydroxy-3-oxohexanoate, a key intermediate for the preparation of HMG-CoA reductase inhibitor.
    Type: Grant
    Filed: September 18, 2003
    Date of Patent: July 7, 2009
    Assignee: Biocon Limited
    Inventors: Sumithra Srinath, Tom Thomas Puthiaparampil, Sambasivam Ganesh
  • PROCESS FOR THE PRODUCTION OF AMORPHOUS ATORVASTATIN CALCIUM
    Publication number: 20090171099
    Abstract: A novel process of the preparation of amorphous atorvastatin calcium starting from a compound of Formula (II).
    Type: Application
    Filed: August 27, 2004
    Publication date: July 2, 2009
    Applicant: BIOCON LIMITED
    Inventors: Sumithra Srinath, Joy Mathew, Tom Thomas Puthiaprampil, Sambasivam Ganesh
  • Process for the Preparation of Amorphous Fluvastatin Sodium
    Publication number: 20080262245
    Abstract: The present invention relates to a novel process for the preparation of the HMG-CoA reductase inhibitor, fluvastatin, more specifically to a process for the preparation of amorphous form of fluvastatin sodium.
    Type: Application
    Filed: October 5, 2004
    Publication date: October 23, 2008
    Inventors: Sumithra Srinath, Tom Thomas Puthiaprampil, Ravindra Chandrapa, Sambasivam Ganesh
  • Process for the production of atorvastatin calcium
    Patent number: 7361772
    Abstract: In one aspect, the invention provides a process for the production of 5-(4-Fluoro-phenyl)-2-isopropyl-4-phenyl-1-(3,5,7-trihydroxy-heptyl)-1H-pyrrole-3-carboxylic acid phenylamide hemicalcium salt, stereoisomers thereof or polymorphs thereof from a (6-{2-[2-(4-Fluoro-phenyl)-5-isopropyl-3-phenyl-4-phenylcarbamoyl-pyrrolidin-1-yl]-ethyl}-2-phenyl-[1,3,2]dioxaborinan-4-yl)-acetic acid tert-butyl ester.
    Type: Grant
    Filed: October 7, 2003
    Date of Patent: April 22, 2008
    Assignee: Biocon Limited
    Inventors: Joy Mathew, Madhavan Sridharan, Sambasivam Ganesh, Tom Thomas Puthiaparampil
  • Form of N-(trans-4-isopropylcyclohexylcarbonyl)-D-phenylalanine
    Patent number: 7314955
    Abstract: The present invention relates to a novel crystalline form of N-(trans-4-isopropylcyclohexylcarbonyl)-D-phenylalanine and methods for preparing the same.
    Type: Grant
    Filed: April 29, 2002
    Date of Patent: January 1, 2008
    Assignee: Biocon Limited
    Inventors: Shanmughasamy Rajamahendra, Chandrashekhar Aswathanarayanappa, Tom Thomas Puthiaparampil, Madhavan Sridharan, Sambasivam Ganesh
  • Boronate esters
    Patent number: 7301046
    Abstract: The present invention relates to optically active boronate derivatives which are useful as intermediates for the synthesis of HMG-CoA enzyme inhibitors such as atorvastatin, cerivastatin rosuvastatin, pitavastatin, and fluvastatin.
    Type: Grant
    Filed: February 25, 2002
    Date of Patent: November 27, 2007
    Assignee: Biocon Limited
    Inventors: Tom Thomas Puthiaparampil, Sumithra Srinath, Madhavan Sridharan, Sambasivam Ganesh
  • Process for Preparation of 4-Fluoro-Alpha-[2-Methyl-1-Oxopropyl]-Gamma-Oxo-N-Beta- Diphenylbenzene Butane Amide
    Publication number: 20070249865
    Abstract: A novel process for the preparation of substantially pure 4-Fluoro-?-[2-methyl-1-oxopropyl]?-oxo-N-?-diphenyl-benzene butane amide.
    Type: Application
    Filed: August 26, 2004
    Publication date: October 25, 2007
    Applicant: BIOCON LIMITED
    Inventors: Joy Mathew, Tom Puthiaprampil, Ravindra Chandrappa, Sambasivam Ganesh
  • Boronate esters
    Patent number: 7238826
    Abstract: The present invention relates to optically active boronate derivatives which are useful as intermediates for the synthesis of HMG-CoA enzyme inhibitors such as atorvastatin, cerivastatin, rosuvastatin, pitavastatin, and fluvastatin.
    Type: Grant
    Filed: August 23, 2004
    Date of Patent: July 3, 2007
    Assignee: Biocon Limited
    Inventors: Tom Thomas Puthiaparampil, Sumithra Srinath, Madhavan Sridharan, Sambasivam Ganesh
  • Process for stereoselective reduction of ?-ketoesters
    Patent number: 7232920
    Abstract: In one aspect, the invention provides a process for the preparation of compounds of Formula I wherein R1 is —CN, —OP, alkyl, aryl or heteroaryl; wherein P represents any suitable protecting group; and R2 is alkyl or aryl; by reacting a compound of Formula II wherein R1 is —CN, —OP, alkyl, aryl or heteroaryl; wherein P represents any suitable protecting group; and R2 is alkyl or aryl; with a reducing agent (e.g. sodium borohydride) in the presence of a metal halid (e.g. CeCl3) or a metal alkoxid (e.g. Ti(OiPr)4).
    Type: Grant
    Filed: April 22, 2003
    Date of Patent: June 19, 2007
    Assignee: Biocon
    Inventors: Tom Thomas Puthiaparampil, Acharya Poornaprajna, Chandrashekar Aswathanarayanappa, Madhavan Sridharan, Sambasivam Ganesh
  • Amorphous HMG-CoA reductase inhibitors of desired particle size
    Patent number: 7230120
    Abstract: In one aspect, the invention provides a process for the preparation of an amorphous HMG-CoA reductase inhibitor and hydrates thereof of desired particle size, which comprises: dissolving the HMG-CoA reductase inhibitor in a hydroxylic solvent, and removing the solvent by freeze-drying.
    Type: Grant
    Filed: March 18, 2002
    Date of Patent: June 12, 2007
    Assignee: Biocon
    Inventors: Acharya Poornaprajna, Joy Mathew, Ravindra Chandrappa, Madhavan Sridharan, Sambasivam Ganesh
  • Process for producing pravastatin sodium salt using dsm 14455
    Patent number: 7189558
    Abstract: In one aspect, the present invention provides an improved method for the manufacture of Pravastatin sodium salt by fermentation under optimal fermentation parameters using a new strain of Streptomyces flavidovirens.
    Type: Grant
    Filed: September 27, 2001
    Date of Patent: March 13, 2007
    Assignee: Biocon Limited
    Inventors: Ramavana Gururaja, Anuj Goel, Madhavan Sridharan, Ramakrishnan Sadhana Melarkode, Madhav Kulkarni, Acharya Poornaprajna, Deepthy Sathyanathan, Sambasivam Ganesh, Shrikumar Suryanarayan
  • Halo-substituted active methylene compounds
    Patent number: 7179942
    Abstract: In one aspect, the invention provides a process for the preparation of a compound of Formula I wherein G is alkyl or aryl, by employing a novel halo-substituted active methylene compound of Formula III wherein X is halogen, and process of preparation thereof.
    Type: Grant
    Filed: June 9, 2003
    Date of Patent: February 20, 2007
    Assignee: Bicon Limited
    Inventors: Joy Mathew, Tom Thomas Puthiaparampil, Madhavan Sridharan, Padudevastana Sathya Shanker, Sambasivam Ganesh
  • Manufacture and purification of cyclosporin A
    Patent number: 7176001
    Abstract: The present invention provides an improved method for the manufacture of Cyclosporin A is disclosed. Cyclosporin A is produced by solid state fermentation of Fusarium solani in a bioreactor under optimal fermentation parameters. The product is extracted and further purified by treating with alum and subsequent chromatographic procedures to get pharmaceutical acceptable purity.
    Type: Grant
    Filed: February 29, 2000
    Date of Patent: February 13, 2007
    Assignee: Biocon Limited
    Inventors: Anand Prakash Khedkar, Pampapathy Subramaniyam, Konayakanahalli Nanjunda Swamy Anand, Melarkode Ramkrishna, Shreehas Pradeep Tambe, Sambasivam Ganesh, Anindya Sircar, Shrikumar Suryanarayan
  • Process for the production of an immunosuppressant
    Patent number: 7122687
    Abstract: In one aspect, the present invention provides a process for producing a sodium salt of an immunosupressant of Formula I
    Type: Grant
    Filed: August 29, 2002
    Date of Patent: October 17, 2006
    Assignee: Sunesis Pharmaceuticals, Inc.
    Inventors: Acharya Poornaprajna, Gopeekrishnan Sreenilayam, Sambasivam Ganesh
  • Process for the production of atorvastatin calcium
    Publication number: 20060084816
    Abstract: In one aspect, the invention provides a process for the production of 5-(4-Fluoro-phenyl)-2-isopropyl-4-phenyl-1-(3,5,7-trihydroxy-heptyl)-1H-pyrrole-3-carboxylic acid phenylamide hemicalcium salt, stereoisomers thereof or polymorphs thereof from a (6-{2-[2-(4-Fluoro-phenyl)-5-isopropyl-3-phenyl-4-phenylcarbamoyl-pyrrolidin-1-yl]-ethyl}-2-phenyl-[1,3,2]dioxaborinan-4-yl)-acetic acid tert-butyl ester.
    Type: Application
    Filed: October 7, 2003
    Publication date: April 20, 2006
    Applicant: BIOCON LIMITED
    Inventors: Joy Mathew, Madhavan Sridharan, Sambasivam Ganesh, Tom Puthiaparampil
  • Novel boronate esters
    Publication number: 20060040898
    Abstract: The present invention relates to optically active boronate derivatives which are useful as intermediates for the synthesis of HMG-CoA enzyme inhibitors such as atorvastatin, cerivastatin, rosuvastatin, pitavastatin, and fluvastatin.
    Type: Application
    Filed: August 23, 2004
    Publication date: February 23, 2006
    Inventors: Tom Puthiaparampil, Sumithra Srinath, Madhavan Sridharan, Sambasivam Ganesh
  • Process for the production of an immunosuppressant
    Publication number: 20050165243
    Abstract: In one aspect, the present invention provides a process for producing a sodium salt of an immunosupressant of Formula I
    Type: Application
    Filed: August 29, 2002
    Publication date: July 28, 2005
    Inventors: Acharya Poornaprajna, Gopeekrishnan Sreenilayam, Sambasivam Ganesh