Patents by Inventor Sameek Singh

Sameek Singh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CHIMERIC SMALL MOLECULES FOR LABELING PROTEINS WITH IMMUNOGENIC MOIETIES AND METHODS OF USE THEREOF
    Publication number: 20250333447
    Abstract: Chimeric small molecules comprising an immunogenic display moiety and methods of using the chimeric small molecules to label proteins with the immunogenic display moiety for MHC display on the surface of a cell or to label cell surface proteins with the immunogenic display moiety for display on the surface of a cell, thereby inducing an immune response.
    Type: Application
    Filed: April 10, 2025
    Publication date: October 30, 2025
    Inventors: Amit Choudhary, Sameek Singh, Kaushik Pal, Endri Karaj, Shaimaa Sindi, Rajaiah Pergu, Jeffrey Fung, Basudeb Mondal, Santosh Chaudhary
  • BIFUNCTIONAL CHIMERIC MOLECULES FOR LABELING OF KINASES WITH TARGET BINDING MOIETIES AND METHODS OF USE THEREOF
    Publication number: 20250277062
    Abstract: The present disclosure relates to chimeric small molecules, which find utility as modifiers of target substrates according to the formula A-L1-E-B or A-L1-E-L2-B, wherein A is a kinase binding moiety; B is a target binding moiety; L1 and L2 are each a linker; and E is an electrophilic reactive group. Molecules according to the present invention find use making substrate modifications such as post-translational modifications to targets that are not the natural substrate of the kinase; accordingly, diseases or disorders may be treated or prevented with molecules of the present disclosure.
    Type: Application
    Filed: December 20, 2024
    Publication date: September 4, 2025
    Inventors: Amit Choudhary, Vika Anokhina, Santosh Chaudhary, Prashant Singh, Sameek Singh, Veronika Shoba, Uttam Dhawa, Ashley Modell, Praveen Tiwari
  • Bifunctional chimeric molecules for labeling of kinases with target binding moieties and methods of use thereof
    Patent number: 12404348
    Abstract: The present disclosure relates to chimeric small molecules, which find utility as modifiers of target substrates according to the formula A-L1-E-B or A-L1-E-L2-B, wherein A is a kinase binding moiety; B is a target binding moiety; L1 and L2 are each a linker; and E is an electrophilic reactive group. Molecules according to the present invention find use making substrate modifications such as post-translational modifications to targets that are not the natural substrate of the kinase; accordingly, diseases or disorders may be treated or prevented with molecules of the present disclosure.
    Type: Grant
    Filed: November 18, 2022
    Date of Patent: September 2, 2025
    Assignees: The Brigham and Women's Hospital, Inc., The Broad Institute, Inc.
    Inventors: Amit Choudhary, Vika Anokhina, Santosh Chaudhary, Prashant Singh, Sameek Singh, Veronika Shoba, Uttam Dhawa, Ashley Modell, Praveen Tiwari