Abstract: The present disclosure relates to acylsulfonamides and processes for their preparation. The processes involve a target-guided synthesis approach, whereby a thioacid and a sulfonyl azide are reacted in the presence of a biological target protein, a Bcl-2 family protein, to form the acylsulfonamide.

Abstract: It is proposed a computer-implemented method for designing a staggered pattern of objects in a computer-aided design system, the method comprising the steps of: providing a reference object to be multi-instantiated; instantiating objects from the reference object for forming a grid with a number of rows and a number of columns, the grid being formed so that the rows are spaced from each other with a first distance in a first direction and each column being spaced from each other with a second distance in a second direction; shifting, in one of every two rows of the grid, the instantiated objects of all the columns of said one of every two rows of the grid with a third distance in the second direction.

Abstract: A rotary electrical machine comprising a rotor having a plurality of equi-angularly spaced magnets is disclosed. The rotor further comprises fan blades, which are advantageously arranged in pairs between adjacent magnets. Air that enters the rotor through the center thereof is impelled radially outwards by the fan blades cooling the magnets. In a further embodiment, a rotary electrical machine in accordance with the present teachings includes at least one concentrically mounted diffuser disc having a plurality of circumferentially disposed equi-angularly spaced diffuser fins. The diffuser fins convert velocity energy into pressure, improving pumping efficiency.