Patents by Inventor Sameer Nikhar

Sameer Nikhar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PROTEIN KINASE INHIBITORS AND USES THEREOF FOR THE TREATMENT OF DISEASES AND CONDITIONS
    Publication number: 20220194937
    Abstract: Identified compounds demonstrate protein kinase inhibitory activity. More specifically, the compounds are demonstrated to inhibit receptor interacting kinase 2 (RIPK2) and/or Activin-like kinase 2 (ALK2) and/or receptor interacting kinase 3 (RIPK3). Compounds that are either dual RIPK2/ALK2 inhibitors or that preferentially inhibit RIPK2 or ALK2 or RIPK3 could provide therapeutic benefit. Compounds that function as RIPK3 inhibitors provide therapeutic benefit in the treatment of inflammatory and degenerative conditions.
    Type: Application
    Filed: May 14, 2020
    Publication date: June 23, 2022
    Inventors: Gregory Cuny, Alexei Degterev, Sameer Nikhar, Siddharth Balachandran
  • PYRIDO[2,3-d]PYRIMIDIN-7-ONES AND RELATED COMPOUNDS AS INHIBITORS OF PROTEIN KINASES
    Publication number: 20220064163
    Abstract: Identified compounds demonstrate protein kinase inhibitory activity. More specifically, the compounds are demonstrated to inhibit receptor interacting kinase 2 (RIPK2) and/or Activin-like kinase 2 (ALK2). Compounds that are either dual RIPK2/ALK2 inhibitors or that preferentially inhibit RIPK2 or ALK2 could provide therapeutic benefit.
    Type: Application
    Filed: October 13, 2021
    Publication date: March 3, 2022
    Applicants: UNIVERSITY OF HOUSTON SYSTEM, TRUSTEES OF TUFTS COLLEGE
    Inventors: Gregory Cuny, Sameer Nikhar, Alexei Degterev
  • Pyrido[2,3-d]pyrimidin-7-ones and related compounds as inhibitors of protein kinases
    Patent number: 11174255
    Abstract: Identified compounds demonstrate protein kinase inhibitory activity. More specifically, the compounds having the structures below (I) are demonstrated to inhibit receptor interacting kinase 2 (RIPK2) and/or Activin-like kinase 2 (ALK2). Compounds that are either dual RIPK2/ALK2 inhibitors or that preferentially inhibit RIPK2 or ALK2 could provide therapeutic benefit.
    Type: Grant
    Filed: May 15, 2018
    Date of Patent: November 16, 2021
    Assignees: UNIVERSITY OF HOUSTON SYSTEM, TRUSTEES OF TUFTS COLLEGE
    Inventors: Gregory Cuny, Sameer Nikhar, Alexei Degterev
  • PYRIDO[2,3-d]PYRIMIDIN-7-ONES AND RELATED COMPOUNDS AS INHIBITORS OF PROTEIN KINASES
    Publication number: 20200172536
    Abstract: Identified compounds demonstrate protein kinase inhibitory activity. More specifically, the compounds having the structures below (I) are demonstrated to inhibit receptor interacting kinase 2 (RIPK2) and/or Activin-like kinase 2 (ALK2). Compounds that are either dual RIPK2/ALK2 inhibitors or that preferentially inhibit RIPK2 or ALK2 could provide therapeutic benefit.
    Type: Application
    Filed: May 15, 2018
    Publication date: June 4, 2020
    Applicants: UNIVERSITY OF HOUSTON SYSTEM, TRUSTEES OF TUFTS COLLEGE
    Inventors: Gregory Cuny, Sameer Nikhar, Alexei Degterev