Abstract: The disclosed computer-implemented method for generating full backups of applications may include (1) storing, at a backup server that is remote from an application, an initial full backup of the application that indicates an initial version of each data block within the application, (2) after storing the full backup of the application, receiving, from the application, an incremental log file generated by the application that indicates at least one change made to a data block within the application after the initial full backup of the application was generated, and (3) creating, by applying the change made to the data block within the application to the initial full backup of the application, an updated full backup of the application that indicates the most current version of each data block within the application. Various other methods, systems, and computer-readable media are also disclosed.

Abstract: An improved excipient comprising substantially homogeneous particles of a compressible, high functionality granular microcrystalline cellulose based excipient is provided. The improved excipient comprises microcrystalline cellulose and a binder, and optionally a disintegrant, and is formed by spraying a homogeneous slurry of the components. The excipient provides enhanced flowability/good flow properties, excellent/high compactibility, and increased API loading and blendability as compared to the individual components, and as compared to conventional excipients formed from the same materials. The improved excipient has strong intraparticle bonding bridges between the components, resulting in a unique structural morphology including significant open structures or hollow pores. The presence of these pores provides a surface roughness that is the ideal environment for improved blending with an API.