Patents by Inventor Sameer S. Sule

Sameer S. Sule has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Polyphosphazene polyelectrolyte immunoadjuvants
    Patent number: 6015563
    Abstract: A polyphosphazene polyelectrolyte immunoadjuvant having improved water solubility, a vaccine composition of the immunoadjuvant and an antigen or immunogen and methods of their use in producing or enhancing an immunoprotective response in a host are disclosed.
    Type: Grant
    Filed: November 4, 1998
    Date of Patent: January 18, 2000
    Assignee: AVANT Immunotherapeutics, Inc.
    Inventors: Alexander K. Andrianov, Lendon G. Payne, Jonathan R. Sargent, Sameer S. Sule
  • Production of polyorganophosphazenes having desired molecular weights
    Patent number: 5869016
    Abstract: A method for producing a polyorganophosphazene, such as, for example, poly?di(carboxylatophenoxy)phosphazenel!, from polydichlorophosphazene. The polydichlorophosphazene is reacted with at least one nucleophilic reagent at a defined molar ratio of the at least one nucleophilic reagent to the polydichlorophosphazene. Such process results in the production of a polyorganophosphazene having a molecular weight within a desired range.
    Type: Grant
    Filed: June 18, 1997
    Date of Patent: February 9, 1999
    Assignee: Virus Research Institute, Inc.
    Inventors: Alexander K. Andrianov, Mark P. LeGolvan, Yuri Svirkin, Sameer S. Sule
  • Polyphosphazene polyelectrolyte immunoadjuvants
    Patent number: 5855895
    Abstract: A polyphosphazene polyelectrolyte immunoadjuvant having improved water solubility, a vaccine composition of the immunoadjuvant and an antigen or immunogen and methods of their use in producing or enhancing an immunoprotective response in a host are disclosed.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: January 5, 1999
    Assignee: Virus Research Institute
    Inventors: Alexander K. Andrianov, Lendon G. Payne, Jonathan R. Sargent, Sameer S. Sule
  • Purification of polyphosphazene polyacids
    Patent number: 5842471
    Abstract: A method for purification of a polyphosphazene polyacid or acid salt thereof in which a polyphosphazene polyacid or acid salt thereof is dissolved in a concentrated aqueous solution of a salt of monovalent ions. The resulting aqueous solution of the polyphosphazene polyacid or acid salt thereof and the at least one salt of monovalent ions then is diluted to reduce the concentration of the at least one salt of monovalent ions, whereby the polyphosphazene polyacid or acid salt thereof is precipitated. The precipitated polyphosphazene polyacid or acid salt thereof then is recovered.
    Type: Grant
    Filed: May 14, 1997
    Date of Patent: December 1, 1998
    Assignee: Virus Research Institute, Inc.
    Inventors: Alexander K. Andrianov, Mark P. LeGolvan, Yuri Svirkin, Sameer S. Sule
  • Recovery of polyphosphazene polyacids or acids salts thereof
    Patent number: 5814704
    Abstract: A process for recovering a polyphosphazene polyacid or acid salt obtained by hydrolyzing a polyphosphazene having at least one ester moiety present in at least one substituent group. The polyphosphazene having at least one ester moiety present in at least one substituent group is hydrolyzed with a base in an organic solvent in the presence of water. The water is present in an amount effective to induce the agglomeration of particles of the synthesized polyphosphazene polyacid or acid salt, which enhances the separation of the polyphosphazene polyacid or acid salt from a polymer-free liquid organic phase. The polymer-free liquid organic phase then is separated from the polyphosphazene acid or acid salt, whereby the polyphosphazene acid or acid salt is recovered.
    Type: Grant
    Filed: March 4, 1997
    Date of Patent: September 29, 1998
    Assignee: Virus Research Institute, Inc.
    Inventors: Alexander K. Andrianov, Jonathan R. Sargent, Sameer S. Sule
  • Polyhalophosphazene solutions stable against gelation
    Patent number: 5707597
    Abstract: A solution which comprises a polyphosphazene solute, such as a polyhalophosphazene solute, and a stabilizing solvent such as diglyme. Such solution enables the polyphosphazene to remain stable for extended periods of time so that such polyhalophosphazenes may be employed for further modification or use.
    Type: Grant
    Filed: November 13, 1996
    Date of Patent: January 13, 1998
    Assignee: Virus Research Institute, Inc.
    Inventors: Alexander K. Andrianov, Jonathan R. Sargent, Sameer S. Sule, Mark LeGolvan