Abstract: A lung injury monitoring system (200) configured to monitor a patient's lungs during ventilation. comprising: an ultrasound device (280) configured to obtain an ultrasound image of the patient's lungs during ventilation of the patient: a processor (220) configured to: (i) receive the obtained ultrasound image: (ii) determine a ventilation phase of the ventilator: (iii) analyze the received ultrasound image: and (iv) determine a risk score for a potential ventilator-associated lung injury (VALI): and a user interface (240) configured to display the determined risk score for the potential VALI.

Abstract: A method for automated detection of water accumulation in a ventilator, comprising: (i) a plurality of iterations of: calculating an airway pressure water accumulation index; calculating a flow water accumulation index; labeling, using a trained asynchrony detection algorithm, the single breath of the patient as synchronous or asynchronous, and ranking all of the input features based on an importance of each respective input feature to the synchronous or asynchronous determination; (ii) for the plurality of iterations; determining, a most frequent breath labeling, a most frequent most important input feature, and a most frequent most important input feature for each type of breath; and determining one or more of: (1) water accumulation and an action to remove the water accumulation; and (2) asynchrony due to a cause other than water accumulation, and an action to correct the asynchrony; and (iii) notifying a user of the determined action.

Abstract: An embodiment provides techniques for distinguishing between breathing events based on sensor data obtained from one or more wearable sensors. In one example, sensor data is obtained that includes one or more of a sensor signal and descriptive metadata of the sensor signal. Processing is applied to distinguish between a cough and another breathing event based on the sensor data, and an indication of a cough is provided.

Abstract: A therapy system has a nasal cannula patient interface configured to deliver gas to a nasal cavity of a patient and a delivery system for delivering oxygen-enriched breathing gas, comprising air and enrichment oxygen, to the patient interface. A sensor is provided allowing arterial partial pressure of CO2, PaCO2 to be measured or estimated thereby to generate capnograph data, A parameter is determined from the capnograph data which is representative of CO2 washout, and the total flow rate, the oxygen flow rate or the air flow rate of the breathing gas delivered by the delivery system are iteratively adjusted while monitoring the determined parameter. A value of total flow rate, oxygen flow rate or air flow rate is used which maximizes CO2 washout or achieves a desired level of CO2 washout.

Abstract: According to an aspect, there is provided a cannula for use in high flow nasal therapy, comprising: a first tube for directing a first fluid from a nasal cavity of a subject to a location outside of the subject; a second tube for directing a second fluid from a supply of the second fluid to the nasal cavity of the subject; a flow sensor located within the first tube, the flow sensor configured to measure a flow rate of the first fluid moving through the first tube; and a humidity sensor located within the first tube, the humidity sensor configured to measure a humidity of the first fluid moving through the first tube; wherein the measured flow rate and the measured humidity are to be used by a processor to control a humidifier to adjust a humidity of the second fluid to be supplied to the subject.

Abstract: According to an aspect, there is provided a ventilator system. The ventilator system comprises: a mouthpiece, to be received within a user's mouth, wherein the mouthpiece comprises: a passage for permitting a flow of gases through the mouthpiece between a first side of the passage to be inside the user's mouth and a second side of the passage to be outside the user's mouth; a passage adjustment component for selectively adjusting a flow area of the passage; and one or more sensors mounted on the mouthpiece, wherein the sensors comprise a pressure sensor configured to measure a pressure at the first side of the passage; and a controller configured to control: a flow rate and/or concentration of oxygen supplied to the user through a nasal cannula; a total flow rate of air and oxygen supplied through the nasal cannula; and/or the flow area of the passage, based on the pressure measured by the pressure sensor.

Abstract: Provided are concepts for controlling a high flow nasal therapy (HFNT) device used by a subject. In particular, physiological and movement parameter values of the subject are leveraged in order to generate a control signal for the HFNT device. These parameters may indicate an activity level of the subject, as well as the condition of the subject, providing information useful for setting appropriate operating conditions of the HFNT device. Thus, a means for automatically controlling a HFNT device based on needs of the subject may be provided, improving subject comfort during therapy, and ease of use of the HFT device.

Abstract: Provided are concepts for generating an indicator of chronic obstructive pulmonary disease (COPD) in a subject. In particular, data from a plurality of sensors, including a pressure sensor, an airflow sensor, and a CO2 concentration sensor is captured from the breath of the subject received by a mouthpiece. The sensor data is then utilised by a processing unit to generate an indicator of COPD in the subject. By utilising airway pressure, airway flow rate and expiratory CO2 concentration data, an accurate indicator of the presence and/or stage of COPD may be obtained.

Abstract: Provided are concepts for generating an indicator of chronic obstructive pulmonary disease (COPD) in a subject. In particular, an elasticated bag suitable for inflation is utilised, such that a change in a measurable characteristic of the elasticated during exhalation of the subject is detected. The change in the measurable characteristic may be analyzed so as to generate an indicator of COPD. Thus, this indicator may be used by a skilled professional in deciding whether to further investigate the possible presence of COPD.

Abstract: Described herein are methods, devices and systems for respiratory therapy delivered by a therapy vest. A therapy vest is provided in which an independent body fitting function is provided by use of a body fit layer or compartment(s). The body fit layer or compartment(s) may be controlled independently from the therapy layer or compartment(s), such that the fit of the therapy vest is placed on more equal footing with the therapy delivering components of the therapy vest. Other examples are disclosed and claimed.

Abstract: An apparatus, comprising a processor and memory storing instructions that, when executed by the processor, cause the processor to: receive ventilator data obtained from continual mechanical ventilatory support of a patient over a period of time, analyze the ventilator data to identify a plurality of breathing cycles, classify the plurality of breathing cycles into normal breathing cycles and abnormal breathing cycles, using a machine learning algorithm, detect a change in the normal breathing cycles, compared to normal breathing cycles identified by the apparatus based on ventilator data obtained from continual mechanical ventilatory support of the patient over a previous period of time, and generate output indicative of the change in the normal breathing cycles.

Abstract: A system is for analyzing physical characteristics of mucus, in particular during patient respiratory support using a ventilator. A ventilation waveform is sensed and analyzed and an estimate of, or a change in, at least one mucus characteristic can then be determined.

Abstract: According to an aspect, there is provided an apparatus for sputum conditioning and analysis. The apparatus comprises: a microfluidic device configured to receive a sputum sample and to separate the sputum sample into a plurality of droplets; a biosensor configured to analyze each of a predetermined number of droplets of the plurality of droplets to acquire measurements of a characteristic of each droplet of the predetermined number of droplets; and a processor configured to analyze the acquired measurements to determine a characteristic of the sputum.

Abstract: The invention provides a positive airway pressure therapy system comprising a positive pressure generation unit, adapted to generate a positive pressure airflow for provision to a subject, and an oscillatory pressure generation unit adapted to modulate the positive pressure airflow at a modulation frequency thereby imparting a frequency component to the positive pressure air flow. The oscillatory pressure generation unit is adapted to modulate the airflow during an exhalation phase of a breathing cycle of the subject.

Abstract: According to an aspect, there is provided a wearable device, the wearable device comprising: an inflatable body configured to be mounted to a torso of a user; a first sensing device, wherein the first sensing device comprises a first sensor and a first actuator coupling the first sensor to the inflatable body; and a memory storing computer-readable instructions that, when executed, cause the wearable device to: inflate the inflatable body from a first state of the inflatable body to a second state of the inflatable body; actuate the first actuator from a first state of the first actuator to a second state of the first actuator, wherein actuating the first actuator from the first state of the first actuator to the second state of the first actuator reduces a volume of a first air gap between the torso and the first sensor; and while the inflatable body is in the second state of the inflatable body and the first actuator is in the second state of the first actuator receive a first signal from the first sensor.