Abstract: The present invention relates to a process for preparation of Batefenterol of Formula (I) or pharmaceutically acceptable salts thereof, and the process for the preparation of the chiral intermediate compounds including compound of Formula (VII) by chiral sulfide mediated epoxidation. The process involves preparation of the intermediate compounds of Formula (VII), followed by preparation of Batefenterol from the intermediate compounds of Formula (VII) via intermediate compounds of Formula (X) and Formula (XI); or via intermediate compounds of Formula (IX) and Formula (XI); or via intermediate compounds of Formula (VII) and Formula (XI); or via intermediate compounds of the Formula (XV) and Formula (XVI); or via intermediate compounds of the Formula (XIX) and Formula (XVI). The process is cost effective and gives higher yield and better purity.

Abstract: The present invention relates to a process for preparation of Navafenterol of Formula (I) and intermediate compounds of Formula (VII) and Formula (XIII) by chiral sulfide mediated epoxidation. The process involves preparation of the intermediate compounds of Formula (VII) and Formula (XIII) followed by preparation of Navafenterol from the compound of Formula (XIII) either by condensation with the compound of Formula (XVI); or via intermediates of the compound of Formula (XVIII) and compound of Formula (XV); or via intermediates of the compound of Formula (XI-a) and compound of Formula (XVI). The process uses simple raw materials and reagents. Further, the process is cost effective and gives higher yield and better purity.

Abstract: The present invention relates to a process for preparation of Abediterol of the Formula (I) or its pharmaceutically acceptable salts, and intermediate compounds including the compound of the Formula (VII) by chiral sulfide mediated epoxidation. The process involves preparation of the intermediate compounds followed by preparation of Abediterol from the intermediate compounds. The compound Abediterol having the formula I is synthesized by various routes from the intermediate compound of Formula (VII). The process is cost effective and gives higher yield and better purity. The process of the present invention uses simple raw materials and reagents; and does not use hypertoxic materials.