Patents by Inventor Sami Mahrus

Sami Mahrus has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Discovery of candidate biomarkers of in vivo apoptosis by global profiling of caspase cleavage sites
    Patent number: 9493522
    Abstract: The present invention relates to the discovery of novel biomarkers of in vivo apoptosis based on a large number of caspase-like cleavage sites. These biomarkers are useful for detection and quantification of apoptosis in a biological sample. The invention also provides synthetic peptides and proteins corresponding to neo-epitopes created by proteolytic processing of these cleavage sites. The synthetic peptides can be used as standards to enable identification and quantitation of these biomarkers using mass spectrometry. The synthetic proteins can be used to generate antibodies and other binding reagents specific for these biomarkers. Methods for detecting apoptosis as well as for diagnosing or for providing a prognosis for a disease or disease state characterized by apoptosis are also provided herein. Finally, the invention provides compositions and kits for performing the methods of the invention.
    Type: Grant
    Filed: January 28, 2011
    Date of Patent: November 15, 2016
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: James A. Wells, Sami Mahrus
  • Specific N-terminal labeling of peptides and proteins in complex mixtures
    Patent number: 8679771
    Abstract: This invention provides general methods for selective labeling of proteins on their N-termini with synthetic peptides. The methods of this invention can be applied to the global proteomic profiling of complex mixtures of proteins and polypeptides.
    Type: Grant
    Filed: January 24, 2008
    Date of Patent: March 25, 2014
    Assignee: The Regents of the University of California
    Inventors: James A. Wells, Sami Mahrus
  • DISCOVERY OF CANDIDATE BIOMARKERS OF IN VIVO APOPTOSIS BY GLOBAL PROFILING OF CASPASE CLEAVAGE SITES
    Publication number: 20120028266
    Abstract: The present invention relates to the discovery of novel biomarkers of in vivo apoptosis based on a large number of caspase-like cleavage sites. These biomarkers are useful for detection and quantification of apoptosis in a biological sample. The invention also provides synthetic peptides and proteins corresponding to neo-epitopes created by proteolytic processing of these cleavage sites. The synthetic peptides can be used as standards to enable identification and quantitation of these biomarkers using mass spectrometry. The synthetic proteins can be used to generate antibodies and other binding reagents specific for these biomarkers. Methods for detecting apoptosis as well as for diagnosing or for providing a prognosis for a disease or disease state characterized by apoptosis are also provided herein. Finally, the invention provides compositions and kits for performing the methods of the invention.
    Type: Application
    Filed: January 28, 2011
    Publication date: February 2, 2012
    Applicant: The Regents of the University of California
    Inventors: James A. Wells, Sami Mahrus
  • SPECIFIC N-TERMINAL LABELING OF PEPTIDES AND PROTEINS IN COMPLEX MIXTURES
    Publication number: 20100143912
    Abstract: This invention provides general methods for selective labeling of proteins on their N-termini with synthetic peptides. The methods of this invention can be applied to the global proteomic profiling of complex mixtures of proteins and polypeptides.
    Type: Application
    Filed: January 24, 2008
    Publication date: June 10, 2010
    Applicant: The Regents of the Universuty of California
    Inventors: James A. Wells, Sami Mahrus