Abstract: Biodegradable nanofiber conical conduits for nerve repair and methods of using same are disclosed. The biodegradable nanofiber conical conduits for nerve repair and methods provide a saturable conduit having a conical shape/geometry including a larger proximal aperture and smaller distal aperture to mechanically guide the regenerating axons across the mismatched repair and thereby prevent axonal escape and neuroma formation. The biodegradable nanofiber conical conduits for nerve repair may include, but are not limited to, a conical conduit that tapers substantially linearly; a conical conduit including a conical concave shape, a conical conduit including a conical convex shape, a conical conduit including proximal and/or distal extensions, a conical conduit including an arrangement of lateral or radial ridges for crimping action, and a conical conduit filled with hydrogel for inhibiting excessive axonal growth.

Abstract: An implantable human-machine interfacing system is disclosed that includes an implantable muscle interface device including a substrate including a first plurality of sensors and a second plurality of amplifiers that capture and amplify, respectively, electromyographic (EMG) signals arising from motor units under control of neural signals representative of volitional limb movements; and a transceiver device connected to the first plurality of sensors that wirelessly transmits signals to an external decoder that produces decoded signals that discriminate motor signals representative of movements of the motor units, wherein the substrate at least partially surrounds a muscle from which the EMG signals arise; and a receiver device that uses the decoded signals for interaction with an external system.