Abstract: A ventilator (10) that pressurizes gas from a body of gas to provide a flow of gas to an airway of a subject (14) such that the gas flow mechanically facilitates the respiration of the subject (14). In order to enhance the comfort of the subject (14) during ventilation by the ventilator (10), the ventilator (10) enables the subject (14) to make unsupervised adjustments to one or more of the properties of the gas flow, within predetermined limits.

Abstract: Provided are systems and methods for humidifying gas to be provided to a patient utilizing heating of an aerosolized mist. A humidification unit (201a) is provided a patient circuit (209) that provides gas to a patient. The humidification unit includes a liquid chamber (303) that receives liquid from a liquid source (203), a nebulizer (305) that nebulizes liquid from the liquid chamber, an aerosol chamber (307) that receives aerosolized liquid from the nebulizer, and a heat source (309a) that converts the aerosolized liquid into a vapor that humidifies gas in the patient circuit.

Abstract: The present disclosure pertains to a ventilation therapy system configured to control a pressure or flow generator to apply an intra-pulmonary percussive ventilation therapy regime to a pressurized flow of breathable gas during baseline ventilation therapy. The ventilation therapy system is configured to automatically control the pressurized flow of breathable gas. The system may automatically control an extent of hyperinflation during IPPV in a subject. The system is configured such that therapy set points, alarm settings, and/or other factors are automatically adjusted during the application of IPPV relative to the set points and alarm settings during baseline ventilation therapy. In some embodiments, the system comprises one or more of a pressure or flow generator, a subject interface, one or more sensors, one or more processors, a user interface, electronic storage, and/or other components.

Abstract: The present disclosure pertains to a high frequency positive pressure ventilation system. The system may be configured to maintain a time-averaged airway pressure level at a target time-averaged airway pressure level and/or a peak-to-peak pressure difference at a target peak-to-peak pressure difference. In some embodiments, the system is configured to control the inspiratory subsystem, the expiratory flow generator and exhalation valve in accordance with a high frequency positive pressure ventilation therapy regime.

Abstract: A system (10) and method of insufflating-exsufflating a subject (12) that enables monitoring and/or control over an enhanced set of breathing parameters during insufflation-exsuffiation. The system and/or method may include automatic triggering and/or notification to a caregiver of insufflation-exsuffiation. The insufflation-exsuffiation of the subject may be preceded by a secretion loosing routine that loosens secretions in the airway of the subject without moving the loosened secretions up the airway.

Abstract: System and methods for providing respiratory therapy include predetermined and/or automatically determined perturbations of levels of pressure, flow, and/or other gas parameters integrated and/or combined (Start with a supplied pressurized flow of breathable gas for a subject. The perturbations are intended to improve secretion management through intra-pulmonary percussive ventilation integrated with ventilation therapy.

Abstract: Systems and methods for providing a ventilator for partial CO2 rebreathing using exhaust valves integrated in a ventilator system to increase a CO2 rebreathing volume of a subject. Non-invasive measurements of CO2 parameters and partial CO2 rebreathing are used to determine noninvasive cardiac output parameters of the subject.

Abstract: Automatically adjusting the trigger sensitivity of a respiratory therapy system includes detecting errors that indicate the trigger sensitivity should be increased, as well as detecting errors that indicate the trigger sensitivity should be reduced. Error detection may be based on the determined muscle pressure of a subject during an inhalation, an attempted inhalation, and/or a suspected attempt of an inhalation.

Abstract: A ventilator system (110) includes: an inhalation filter (120) configured to receive and filter a gas; a humidifier (130) connected to the inhalation filter and configured to adjust a humidity of the filtered gas; a dual-limb patient circuit connected to a patient and configured to supply ventilation to the patient, the dual limb patient circuit including an inspiratory limb connected to the humidifier and configured to supply the filtered gas to the patient and an expiratory limb configured to receive an exhaled gas from the patient; a condenser (140) connected to the expiratory limb, the condenser being configured to cool and remove moisture from the gas from the patient; and an expiratory filter (150) connected to the condenser and configured to filter the cooled gas from the condenser.

Abstract: A method and apparatus provide closed-loop control of the operation of a ventilator device based on physiological parameters received from and/or through a patient monitor device, which is a separate and discrete device from the ventilator device.

Abstract: Determining the lung compliance and lung resistance of a subject undergoing respiratory therapy using non-invasive ventilation requires taking the presence of leaks into account. In particular, variable and unintentional leaks at or near a subject interface appliance may be dynamically determined based on an average resistance of the leak orifice of the subject.

Abstract: A valve (100) for controlling pressure in a ventilation system is disclosed. The valve comprises an electromagnet (105, 106), a shaft (107) connected to the electromagnet, and a diaphragm (110) connected to the shaft, wherein the electromagnet applies force to the diaphragm based on an input. The ventilation system comprises a ventilator (200) connected to a patient circuit (204), the valve (100) controlling pressure in the ventilation system, and a controller (206) connected to the valve and configured to provide the input to the valve.

Abstract: Provided are systems for humidifying gas delivered to a patient. A humidifier unit (107) is provided located proximal to a patient interface (105) of a patient circuit (103). The humidifier unit includes a chamber that receives water from a water source (109), a heat source disposed within the chamber, a water flow sensor (113), an output temperature sensor (117), an output humidity sensor, and/or other sensors. A controller (119) receives flow data relating to water being provided to the chamber and temperature data relating to the temperature of the humidified gas, humidity, and/or other data. The controller further adjusts a flow of water being provided to the chamber based on the flow data and/or a heat output of the heat source based on the received data.

Abstract: Provided are systems and methods for humidifying gas to be provided to a patient utilizing heating of an aerosolized mist. A humidification unit (201a) is provided a patient circuit (209) that provides gas to a patient. The humidification unit includes a liquid chamber (303) that receives liquid from a liquid source (203), a nebulizer (305) that nebulizes liquid from the liquid chamber, an aerosol chamber (307) that receives aerosolized liquid from the nebulizer, and a heat source (309a) that converts the aerosolized liquid into a vapor that humidifies gas in the patient circuit.

Abstract: A secondary line purging system (40) having a blower (22) for pressurizing a flow of gas and a first pressure sensor (28) for measuring a first pressure of the flow of gas at or near the blower. The system also includes a secondary line (36) communicating with the blower and a subject circuit (32). The system further includes a second pressure sensor (30) for measuring a second pressure of the flow of gas within the secondary line. A valve system (42) is operable in 1) a first mode of operation to isolate the blower from the secondary line and 2) a second mode of operation to permit communication between the blower to the secondary line to purge the secondary line of obstructions with the pressurized flow of gas. A controller (16) switches operation of the valve system between the first mode of operation and the second mode of operation, based on the first pressure and the second pressure.

Abstract: A pressurized flow of breathable gas is delivered to the airway of a subject to facilitate respiration by the subject. To enhance the effectiveness of the pressurized flow of breathable gas, stochastic fluctuations in the level of pressure at or near the airway of the subject are created. These stochastic fluctuations mimic similar oscillations present in so-called “bubble CPAP” systems. Since these stochastic fluctuations are intended to maintain the openness of the airway of the subject, and not to drive ventilation, these fluctuations tend to have a higher frequency and/or lower magnitude than changes in pressure that drive ventilation.

Abstract: A ventilator includes first and second pathways, a conduit and a controller. The first pathway (120) is configured to supply a first gas and the second pathway (140) is configured to supply a second gas, where the second gas is mixed with the first gas to produce mixed gas having a predetermined percentage of the second gas. The conduit (166) is configured to provide the mixed gas from the first and second pathways to an access port during an inspiratory phase, and to provide discharged gas from the access port to the first pathway during an expiratory phase. The controller (180) is configured to delay supply of the second gas from the second pathway for a delay time in order to maintain the predetermined percentage of the second gas in the mixed gas provided to the access port during a subsequent inspiratory phase.

Abstract: A system (10) and method of insufflating-exsufflating a subject (12) that enables monitoring and/or control over an enhanced set of breathing parameters during insufflation-exsuffiation. The system and/or method may include automatic triggering and/or notification to a caregiver of insufflation-exsuffiation. The insufflation-exsuffiation of the subject may be preceded by a secretion loosing routine that loosens secretions in the airway of the subject without moving the loosened secretions up the airway.

Abstract: A method for signaling a failure condition of a bearing of a turbocharger that includes a sensor configured for sensing information on off-axis rotor motion. The method entails receiving a stream of information from the sensor, decomposing the stream of information into a set of components representing different frequencies, using a subset of components that represent a range of frequencies known to be indicative of bearing failure to calculate a probability of failure of the bearing, signaling a failure condition of the bearing if the probability of failure exceeds a critical threshold, and if the present indicia of off-axis rotor motion does not indicate a complete failure condition has occurred, determining a time interval until another probability of failure of the bearing will be calculated. The time interval can vary based upon the rate that the probability of failure has changed over multiple time intervals.