Abstract: Embodiments herein describe systems and methods for scalable mapping of brain dynamics and uses thereof are provided. Many embodiments are capable of mapping brain dynamics in a computationally efficient way. In many embodiments, shape graphs can be produced which can operate as interactive network representations of dynamic brain activity data. Methods for automatically interpreting the structure of the shape graphs are described herein. In various embodiments, the mapped brain dynamics can be used to indicate which type of treatment protocol is likely to be most effective for the particular individual. In many embodiments, the treatment includes transcranial magnetic stimulation, pharmaceutical treatment, and/or any other mental condition treatment as appropriate to the requirements of specific applications of embodiments of the invention.

Abstract: Systems and methods of a medical analytics system are described herein. The medical analytics system can include a machine learning model for processing patient tissue images for either training the machine learning model or for clinical use, such as providing information for assisting a clinician with at least diagnosing a disease or condition of a patient. Implementations of the medical analytics system can further include a user interface that is configured to allow a user to interact with a patient image for assisting with diagnosing at least a part of the tissue captured in the patient image.

Abstract: Systems and methods of a medical analytics system are described herein. The medical analytics system can include a machine learning model for processing patient tissue images for either training the machine learning model or for clinical use, such as providing information for assisting a clinician with at least diagnosing a disease or condition of a patient. Implementations of the medical analytics system can further include a user interface that is configured to allow a user to interact with a patient image for assisting with diagnosing at least a part of the tissue captured in the patient image.

Abstract: Systems and methods of a medical analytics system are described herein. The medical analytics system can include a machine learning model for processing patient tissue images for either training the machine learning model or for clinical use, such as providing information for assisting a clinician with at least diagnosing a disease or condition of a patient. Implementations of the medical analytics system can further include a user interface that is configured to allow a user to interact with a patient image for assisting with diagnosing at least a part of the tissue captured in the patient image.

Abstract: An imaging radiation detector includes a scintillator coupled to an array of photodiodes operating in Geiger mode. The array is divided into separate detector pixels, each of which is composed of a multiplicity of photodiode cells with their outputs tied together. While each of the cells operates independently in a binary or digital mode, by tying together the outputs of a multiplicity of adjacent photodiode cells forming a single pixel, the sum of the outputs is proportional to the intensity of generated scintillation photons, similar to the output of a PMT. Appropriate quenching circuitry is provided to rapidly reset the photodiodes after scintillation photon detection.

Abstract: A nuclear medicine imaging system is disclosed that includes a detector including a plurality of silicon strip sensor arrays surrounding a scintillator. In some embodiments, strip detectors can be provided that can lead to significant cost benefits as compared to existing detectors, such as existing nuclear detectors. The preferred embodiments may be applied in nuclear medical cameras, while other embodiments may be applied in other radiation applications, whether medical or non-medical applications.

Abstract: A collimator for a nuclear imaging device includes, i.e., is formed from, a tungsten polymer. Preferably, the tungsten polymer includes at least 50% by weight of tungsten powdered tungsten mixed with polymer and has a density substantially equivalent to that of lead. Preferably, the collimator includes at least one of a slat, a parallel hole, a pinhole, a multi-pinhole, a square hole, a hexagonal hole, a fan beam, a diverging and a converging beam type-collimator. Preferably, the collimator has a thickness from 0.01 to 1.1 cm and a photon stopping power of from 0.5 to 50% for stopping photons having energy levels from 50 to 200 keV.

Abstract: An imaging radiation detector includes a scintillator coupled to an array of photodiodes operating in Geiger mode. The array is divided into separate detector pixels, each of which is composed of a multiplicity of photodiode cells with their outputs tied together. While each of the cells operates independently in a binary or digital mode, by tying together the outputs of a multiplicity of adjacent photodiode cells forming a single pixel, the sum of the outputs is proportional to the intensity of generated scintillation photons, similar to the output of a PMT. Appropriate quenching circuitry is provided to rapidly reset the photodiodes after scintillation photon detection.

Abstract: A gamma camera having a scintillation detector formed of multiple bar detector modules. The bar detector modules in turn are formed of multiple scintillation crystal bars, each being designed to have physical characteristics, such as light yield, to achieve a sufficient spatial resolution for nuclear medical imaging applications. According to another aspect of the invention, the bar detector modules are arranged in a three-dimensional array, where each module is made up of a two-dimensional array of bar detectors with at least one photosensor optically coupled to each end of the module. Such a camera can be used for both PET (coincidence) and single photon imaging applications. According to another aspect of the invention, a bar detector gamma camera is provided, which utilizes an improved positioning algorithm that greatly enhances spatial resolution in the z-axis direction (i.e., the direction along the length of the scintillation crystal bar).

Abstract: A multi-pinhole collimator nuclear medical imaging detector divides a target object space into many non-overlapping areas and projects a minified image of each area onto a segmented detector, where each segment functions as an independent detector or imaging cell. Septa may be provided between the collimator and the detector, to physically isolate the segments.

Abstract: A multi-pinhole collimator nuclear medical imaging detector divides a target object space into many non-overlapping areas and projects a minified image of each area onto a segmented detector, where each segment functions as an independent detector or imaging cell. Septa may be provided between the collimator and the detector, to physically isolate the segments.

Abstract: A method and apparatus for improving the energy resolution, sensitivity and other aspects of a x-ray or gamma ray detector by using modified acquisition electronics in conjunction with low leakage current photodiodes. Specifically, increasing the integration time of the sample circuits without degrading energy resolution due to parallel noise in order to improve energy resolution and sensitivity, and to allow new electronics designs.

Abstract: A collimator device for a nuclear imaging camera has a grid of collimation square holes formed by a plurality of elongated, metal sheets arranged in a grid pattern, and pixellated scintillators individually located in each of the collimation square holes. Each of the metal sheets has evenly spaced slots into which other sheets are inserted. At least a portion of the surfaces of the sheets forming the grid of the collimation square holes is coated with an optically reflecting material coating.

Abstract: A gamma camera having a scintillation detector formed of multiple bar detector modules. The bar detector modules in turn are formed of multiple scintillation crystal bars, each being designed to have physical characteristics, such as light yield, to achieve a sufficient spatial resolution for nuclear medical imaging applications. According to another aspect of the invention, the bar detector modules are arranged in a three-dimensional array, where each module is made up of a two-dimensional array of bar detectors with at least one photosensor optically coupled to each end of the module. Such a camera can be used for both PET (coincidence) and single photon imaging applications. According to another aspect of the invention, a bar detector gamma camera is provided, which utilizes an improved positioning algorithm that greatly enhances spatial resolution in the z-axis direction (i.e., the direction along the length of the scintillation crystal bar).

Abstract: A radiation detection that employs an array of carbon-based photodetectors (CBPD) to convert scintillation photons into electronic signals is disclosed. According to one embodiment, the carbon-based photodiode consists of a p-type semiconductor and an n-type semiconductor. Further, the p-type semiconductor and n-type semiconductors are a conjugated polymer and a media comprised of fullerenes respectively.

Abstract: A method and apparatus for improving the energy resolution, sensitivity and other aspects of a x-ray or gamma ray detector by using modified acquisition electronics in conjunction with low leakage current photodiodes. Specifically, increasing the integration time of the sample circuits without degrading energy resolution due to parallel noise in order to improve energy resolution and sensitivity, and to allow new electronics designs.