Patents by Inventor Samir Hamamah

Samir Hamamah has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS FOR DETERMINING THE QUALITY OF AN EMBRYO
    Publication number: 20220106643
    Abstract: The present invention relates generally to the fields of reproductive medicine. More specifically, the present invention relates to in vitro non invasive methods and kits for determining the quality of an embryo by determining the level of the cell free nucleic acids and/or determining the presence and/or expression level of at least one specific nucleic acid sequence in the nucleic acid extraction.
    Type: Application
    Filed: September 13, 2021
    Publication date: April 7, 2022
    Inventors: Samir HAMAMAH, Safia EL MESSAOUDI, Alain THIERRY, Said ASSOU
  • Methods for assessing pregnancy outcome
    Patent number: 11230736
    Abstract: The invention relates to a method of assessing pregnancy outcome. The inventors investigated endometrial miRNAs associated with pregnancy outcome by studying miRNAs associated with endometrial receptivity, implantation failure and embryo miscarriage. They performed a miRNomic study to find miRNAs that are differentially expressed according to the endometrial receptivity status, compared the endometrial miRNome between receptive patients with negative beta-hCG and receptive patients with positive beta-hCG, and compared the endometrial miRNome between receptive patients with a miscarriage between 8-12 weeks of amenorrhoea and receptive patients with a live birth. They demonstrated miRNA differential expression in endometrial samples according to the pregnancy outcome.
    Type: Grant
    Filed: March 28, 2018
    Date of Patent: January 25, 2022
    Assignees: INSERM (Institut National de la Santé de la Recherche Médicale), Université de Montpellier, Centre Hospitalier Universitaire de Montpellier
    Inventors: Samir Hamamah, Delphine Haouzi
  • Methods for determining the quality of an embryo
    Patent number: 11149314
    Abstract: The present invention relates generally to the fields of reproductive medicine. More specifically, the present invention relates to in vitro non invasive methods and kits for determining the quality of an embryo by determining the level of the cell free nucleic acids and/or determining the presence and/or expression level of at least one specific nucleic acid sequence in the nucleic acid extraction.
    Type: Grant
    Filed: September 19, 2018
    Date of Patent: October 19, 2021
    Assignees: INSERM (Institut National de la Santé et de la Recherche Médicale), Université de Montpellier, Centre Hospitalier Universitaire de Montpellier, Institut Régional du Cancer de Montpellier
    Inventors: Samir Hamamah, Safia El Messaoudi, Alain Thierry, Said Assou
  • Methods employing circulating DNA and miRNA as biomarkers for female infertility
    Patent number: 10731218
    Abstract: The present invention relates generally to the fields of reproductive medicine. More specifically, the present invention relates to methods for determining the ovarian reserve and ovarian function by determining the level of cell-free nucleic acids or the level of a miRNA species selected from miR_30_a or miR_140 or let_7_b or miR_191 or miR_320_a or miR_21 or miR_30_d or miR_574_3p. The method may also be used in predicting the efficacy of controlled ovarian hyperstimulation.
    Type: Grant
    Filed: June 20, 2019
    Date of Patent: August 4, 2020
    Assignees: INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE), UNIVERSITE DE MONTPELLIER, CENTRE HOSPITALIER UNIVERSITAIRE DE MONTPELLIER
    Inventors: Samir Hamamah, Sabine Traver, Elodie Scalici
  • Methods for three dimensional reconstruction and determining the quality of an embryo
    Patent number: 10628944
    Abstract: The present invention relates generally to the fields of reproductive medicine. More specifically, the present invention relates to methods and devices for determining the quality of an embryo. More specifically, the present invention relates to the use of three dimensional reconstructions for determining the quality of an embryo.
    Type: Grant
    Filed: July 1, 2015
    Date of Patent: April 21, 2020
    Assignees: INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE), UNIVERSITE DE MONTPELLIER, CENTRE HOSPITALIER UNIVERSITAIRE DE MONPELLIER
    Inventors: Samir Hamamah, Elodie Scalici
  • METHODS FOR ASSESSING PREGNANCY OUTCOME
    Publication number: 20200040395
    Abstract: The invention relates to a method of assessing pregnancy outcome. The inventors investigated endometrial miRNAs associated with pregnancy outcome by studying miRNAs associated with endometrial receptivity, implantation failure and embryo miscarriage. They performed a miRNomic study to find miRNAs that are differentially expressed according to the endometrial receptivity status, compared the endometrial miRNome between receptive patients with negative beta-hCG and receptive patients with positive beta-hCG, and compared the endometrial miRNome between receptive patients with a miscarriage between 8-12 weeks of amenorrhoea and receptive patients with a live birth. They demonstrated miRNA differential expression in endometrial samples according to the pregnancy outcome.
    Type: Application
    Filed: March 28, 2018
    Publication date: February 6, 2020
    Inventors: Samir HAMAMAH, Delphine HAOUZI
  • METHODS EMPLOYING CIRCULATING DNA AND MIRNA AS BIOMARKERS FOR FEMALE INFERTILITY
    Publication number: 20190367987
    Abstract: The present invention relates generally to the fields of reproductive medicine. More specifically, the present invention relates to methods for determining the ovarian reserve and ovarian function by determining the level of cell-free nucleic acids or the level of a miRNA species selected from miR_30_a or miR_140 or let_7_b or miR_191 or miR_320_a or miR_21 or miR_30_d or miR_574_3p. The method may also be used in predicting the efficacy of controlled ovarian hyperstimulation.
    Type: Application
    Filed: June 20, 2019
    Publication date: December 5, 2019
    Inventors: Samir HAMAMAH, Sabine TRAVER, Elodie SCALICI
  • Methods employing circulating DNA and miRNA as biomarkers for female infertility
    Patent number: 10400282
    Abstract: The present invention relates generally to the fields of reproductive medicine. More specifically, the present invention relates to methods for determining the ovarian reserve and ovarian function by determining the level of cell-free nucleic acids or the level of a miRNA species selected from miR_30_a or miR_140 or let_7_b or miR_191 or miR_320_a or miR_21 or miR_30_d or miR_574_3p. The method may also be used in predicting the efficacy of controlled ovarian hyperstimulation.
    Type: Grant
    Filed: June 26, 2015
    Date of Patent: September 3, 2019
    Assignees: INSERM (INSTITUT NATIONAL DE LA SANTÉET DE LA RECHERCHE MÉDICALE), UNIVERSITE DE MONTPELLIER, CENTRE HOSPITALIER UNIVERSITAIRE DE MONTPELLIER
    Inventors: Samir Hamamah, Sabine Traver, Elodie Scalici
  • Free nucleic acids and miRNA as non-invasive method for determining embryo quality
    Patent number: 10184150
    Abstract: The present invention relates generally to the fields of reproductive medicine. More specifically, the present invention relates to in vitro non-invasive methods for determining the quality of an embryo by determining the level of the cell free nucleic acids or miR-29a or let7-b in the nucleic acid extract from a follicular fluid sample.
    Type: Grant
    Filed: June 26, 2015
    Date of Patent: January 22, 2019
    Assignees: INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE), UNIVERSITÉ DE MONTPELLIER, CENTRE HOSPITALIER UNIVERSITAIRE DE MONTPELLIER
    Inventors: Samir Hamamah, Elodie Scalici, Sabine Traver
  • METHODS FOR DETERMINING THE QUALITY OF AN EMBRYO
    Publication number: 20190002985
    Abstract: The present invention relates generally to the fields of reproductive medicine. More specifically, the present invention relates to in vitro non invasive methods and kits for determining the quality of an embryo by determining the level of the cell free nucleic acids and/or determining the presence and/or expression level of at least one specific nucleic acid sequence in the nucleic acid extraction.
    Type: Application
    Filed: September 19, 2018
    Publication date: January 3, 2019
    Inventors: Samir HAMAMAH, Safia EL MESSAOUDI, Alain THIERRY, Said ASSOU
  • Methods for selecting competent oocytes and competent embryos with high potential for pregnancy outcome
    Patent number: 10059994
    Abstract: The present invention relates to a method for selecting a competent oocyte or a competent embryo by determining the expression level of specific microRNA species in a body fluid or in cumulus cells.
    Type: Grant
    Filed: November 21, 2016
    Date of Patent: August 28, 2018
    Assignees: INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE), UNIVERSITE DE MONTPELLIER 1, CENTRE HOSPITALIER UNIVERSITAIRE DE MONTPELLIER
    Inventors: Samir Hamamah, Said Assou
  • METHODS EMPLOYING CIRCULATING DNA AND MIRNA AS BIOMARKERS FOR FEMALE INFERTILITY
    Publication number: 20170152561
    Abstract: The present invention relates generally to the fields of reproductive medicine. More specifically, the present invention relates to methods for determining the ovarian reserve and ovarian function by determining the level of cell-free nucleic acids or the level of a miRNA species selected from miR_30_a or miR_140 or let_7_b or miR_191 or miR_320_a or miR_21 or miR_30_d or miR_574_3p. The method may also be used in predicting the efficacy of controlled ovarian hyperstimulation.
    Type: Application
    Filed: June 26, 2015
    Publication date: June 1, 2017
    Inventors: Samir HAMAMAH, Sabine TRAVER, Elodie SCALICI
  • FREE NUCLEIC ACIDS AND MIRNA AS NON-INVASIVE METHOD FOR DETERMINING EMBRYO QUALITY
    Publication number: 20170152557
    Abstract: The present invention relates generally to the fields of reproductive medicine. More specifically, the present invention relates to in vitro non-invasive methods for determining the quality of an embryo by determining the level of the cell free nucleic acids or miR-29a or let7-b in the nucleic acid extract from a follicular fluid sample.
    Type: Application
    Filed: June 26, 2015
    Publication date: June 1, 2017
    Inventors: Samir HAMAMAH, Elodie SCALICI, Sabine TRAVER
  • METHODS FOR THREE DIMENSIONAL RECONSTRUCTION AND DETERMINING THE QUALITY OF AN EMBRYO
    Publication number: 20170140535
    Abstract: The present invention relates generally to the fields of reproductive medicine. More specifically, the present invention relates to methods and devices for determining the quality of an embryo. More specifically, the present invention relates to the use of three dimensional reconstructions for determining the quality of an embryo.
    Type: Application
    Filed: July 1, 2015
    Publication date: May 18, 2017
    Inventors: Samir HAMAMAH, Elodie SCALICI
  • METHODS FOR SELECTING COMPETENT OOCYTES AND COMPETENT EMBRYOS WITH HIGH POTENTIAL FOR PREGNANCY OUTCOME
    Publication number: 20170067105
    Abstract: The present invention relates to a method for selecting a competent oocyte or a competent embryo by determining the expression level of specific microRNA species in a body fluid or in cumulus cells.
    Type: Application
    Filed: November 21, 2016
    Publication date: March 9, 2017
    Applicants: INSERM (Institut National de la Sante et de la Recherche Medicale), UNIVERSITE DE MONTPELLIER 1, Centre Hospitalier Universitaire de Montpellier
    Inventors: Samir HAMAMAH, Said ASSOU
  • Methods for determining developmental stage of human cumulus cells
    Patent number: 9481863
    Abstract: The present invention relates generally to the fields of reproductive medicine. More specifically, the present invention relates to a method determining the developmental stage of human cumulus cells issues from MII oocyte.
    Type: Grant
    Filed: June 29, 2012
    Date of Patent: November 1, 2016
    Assignees: INSERM (Institut National de la Santé et de la Recherche Médicale), CENTRE HOSPITALIER UNIVERSITAIRE DE MONTPELLIER, UNIVERSITE DE MONTPELLIER 1
    Inventor: Samir Hamamah
  • Methods for assessing endometrial receptivity of a patient after controlled ovarian hyperstimulation
    Patent number: 9453259
    Abstract: Disclosed herein are methods and kits for assessing the endometrial receptivity of a patient after controlled ovarian hyperstimulation. More particularly, provided herein is a method for assessing the endometrial receptivity of a patient after controlled ovarian hyperstimulation, comprising a step consisting of measuring the expression level of at least one gene selected from fifteen genes in an endometrial biopsy sample obtained from the patient wherein the genes are FGFBP1, MUC20, TMPRSS3, PRUNE2, HES2, MGST1, ERRFI1, EDN1, SLC17A7, MET, CPT1B, DCDC2, LRRC39, IL18RAP, and FOXP1.
    Type: Grant
    Filed: October 22, 2012
    Date of Patent: September 27, 2016
    Assignees: INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE), UNIVERSITE DE MONTPELLIER 1, Centre Hospitalier Universitaire de Montpellier
    Inventors: Samir Hamamah, Delphine Haouzi
  • METHODS FOR SELECTING COMPETENT OOCYTES AND COMPETENT EMBRYOS WITH HIGH POTENTIAL FOR PREGNANCY OUTCOME
    Publication number: 20160201128
    Abstract: The present invention relates to a method for selecting a competent oocyte or a competent embryo.
    Type: Application
    Filed: July 24, 2015
    Publication date: July 14, 2016
    Applicants: INSERM (Institut National de la Sante et de la Recherche Medicale), UNIVERSITE DE MONTPELLIER 1, Centre Hospitalier Universitaire de Montpellier
    Inventors: Samir HAMAMAH, Said ASSOU
  • Methods of growing an embryo to a blastocyst stage of development
    Patent number: 9365820
    Abstract: The present invention relates generally to the fields of reproductive medicine. More specifically, the present invention relates to a novel human embryo co-culture system to improve human embryo growth in vitro and, consequently, increase pregnancy rates in infertile women undergoing in vitro fertilization (IVF) treatment. More particularly, the present invention relates to a method of growing an embryo to a blastocyst stage of development comprising the step of coculturing said embryo in the presence of a population of cumulus cells.
    Type: Grant
    Filed: November 5, 2014
    Date of Patent: June 14, 2016
    Assignees: Institut National de la Santa et de la Recherche Medicale (INSERM), Université Montpellier 1, Centre Hospitalier Universitaire de Montpellier
    Inventors: Samir Hamamah, Said Assou
  • METHODS FOR DETERMINING THE QUALITY OF AN EMBRYO
    Publication number: 20160138104
    Abstract: The present invention relates generally to the fields of reproductive medicine. More specifically, the present invention relates to in vitro non invasive methods and kits for determining the quality of an embryo by determining the level of the cell free nucleic acids and/or determining the presence and/or expression level of at least one specific nucleic acid sequence in the nude is acid extraction.
    Type: Application
    Filed: June 18, 2014
    Publication date: May 19, 2016
    Inventors: Samir HAMAMAH, Safia EL MESSAOUDI, Alain THIERRY, Said ASSOU