Patents by Inventor Samir Jegham

Samir Jegham has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NOVEL COMBINATIONS FOR TREATING ACUTE MYELOID LEUKAEMIA OR CHRONIC MYELOID LEUKAEMIA
    Publication number: 20150005253
    Abstract: The present disclosure relates to combinations of N-[2-(2,1,3-benzothiadiazol-5-ylamino)-6-(2,6-dichlorophenyl)pyrido[2,3-d]pyrimidin-7-yl]-N?-(1,1-dimethylethyl)-urea and cytarabine and their use for treating AML or CML.
    Type: Application
    Filed: September 12, 2014
    Publication date: January 1, 2015
    Inventors: Bernard BOURRIE, Pierre CASELLAS, Sylvie COSNIER-PUCHEU, Samir JEGHAM, Pierre PERREAUT
  • ANTICANCER DERIVIATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF
    Publication number: 20120094986
    Abstract: The invention relates to nicotinamide derivatives which can be used as anticancer drugs.
    Type: Application
    Filed: March 22, 2010
    Publication date: April 19, 2012
    Applicant: SANOFI-AVENTIS
    Inventors: Jérôme Arigon, Claude Bernhart, Monsif Bouaboula, Romain Combet, Sandrine Hilairet, Samir Jegham
  • ANTICANCER COMPOUNDS, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF
    Publication number: 20120053209
    Abstract: The invention relates to nicotinamide derivatives that can be used as anticancer drugs.
    Type: Application
    Filed: March 18, 2010
    Publication date: March 1, 2012
    Applicant: SANOFI
    Inventors: Jerome Arigon, Claude Bernhart, Monsif Bouaboula, Romain Combet, Samir Jegham, Sandrine Hilairet
  • NICOTINAMIDE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF AS ANTICANCER DRUGS
    Publication number: 20120053170
    Abstract: The present invention relates to nicotinamide derivatives of formula (I), to compositions containing same, and to the therapeutic use thereof, in particular as anticancer drugs. The invention also relates to the method for preparing said compounds, as well as to some of the intermediate products.
    Type: Application
    Filed: March 22, 2010
    Publication date: March 1, 2012
    Applicant: SANOFI
    Inventors: Jérome Arigon, Claude Bernhart, Monsif Bouaboula, Romain Combet, Sandrine Hilairet, Samir Jegham
  • 6-heteroarylpyridoindolone derivatives, their preparation and therapeutic use thereof
    Patent number: 8063061
    Abstract: The disclosure relates to compounds of formula (I): wherein R1, R2, R3, R4, are R5 are as defined in the disclosure; their preparation method, compositions containing the same and therapeutic use thereof.
    Type: Grant
    Filed: April 9, 2008
    Date of Patent: November 22, 2011
    Assignee: Sanofi-Aventis
    Inventors: Yvette Muneaux, Samir Jegham, Bernard Bourrie, Pierre Casellas, Paola Ciapetti, Jean-Marie Deroco, Camille-Georges Wermuth
  • ANTINEOPLASTIC DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF
    Publication number: 20110251194
    Abstract: The disclosure concerns heterobicyclic compounds of general formula (I) and acid addition salts, hydrates and solvates thereof, as well as enantiomers, diastereoisomers and mixtures thereof. Methods for preparing the compounds, pharmaceutical compositions, and methods of treatment also are disclosed.
    Type: Application
    Filed: January 7, 2011
    Publication date: October 13, 2011
    Applicant: SANOFI-AVENTIS
    Inventors: Claude BERNHART, Gary MCCORT, Samir JEGHAM, Jean Marc HERBERT, Pierre CASELLAS, Monsif BOUABOULA, Olivier DUCLOS
  • Pyridoindolone derivatives substituted in the 3-position by a phenyl, their preparation and their application in therapeutics
    Patent number: 8012991
    Abstract: The present disclosure relates to pyridoindolone derivatives of general formula (I): to processes for preparing the same and to their use in therapeutics.
    Type: Grant
    Filed: May 12, 2008
    Date of Patent: September 6, 2011
    Assignee: Sanofi-Aventis
    Inventors: Bernard Bourrie, Pierre Casellas, Paola Ciapetti, Jean-Marie Derocq, Samir Jegham, Yvette Muneaux, Camille-Georges Wermuth
  • Derivatives of pyrido[2,3-d]pyrimidine, the preparation thereof, and the therapeutic application of the same
    Patent number: 8008310
    Abstract: Derivatives of pyrido[2,3-d]pyrimidine are provided having formula (I) with Ar1, Ar2 and R1 as defined herein, which are useful for treating cell proliferative conditions, and to the preparation thereof, and to the therapeutic application of the same.
    Type: Grant
    Filed: January 30, 2009
    Date of Patent: August 30, 2011
    Assignee: Sanofi-Aventis
    Inventors: Bernard Bourrie, Pierre Casellas, Samir Jegham, Claude Muneaux, Pierre Perreaut
  • Pyrido-pyrimidine derivatives, preparation thereof, and therapeutic use thereof
    Patent number: 7893259
    Abstract: The disclosure concerns pyrido[2,3-d]pyrimidine derivatives, their preparation and their therapeutic application, of general formula (I): and acid addition salts, hydrates and solvates thereof, as well as in the form of enantiomers, diastereoisomers and mixtures thereof. The disclosure also concerns methods for preparing said derivatives, pharmaceutical compositions containing a compound of general formula (I), and their therapeutic use.
    Type: Grant
    Filed: March 31, 2009
    Date of Patent: February 22, 2011
    Assignee: Sanofi-Aventis
    Inventors: Bernard Bourrie, Pierre Casellas, Samir Jegham, Pierre Perreaut
  • Pyridopyrimidone derivatives, preparation thereof, therapeutic use thereof
    Patent number: 7842806
    Abstract: The disclosure relates to pyrido[2,3-d]pyrimidone compounds, to the preparation thereof and to the therapeutic use thereof, wherein said compounds are of general formula (I): in the form of a base or of an addition salt with an acid which is pharmaceutically acceptable, in the form of hydrates or of solvates, and also in the form of enantiomers, diastereoisomers and a mixture thereof. The disclosure also relates to processes for preparing said compounds, to pharmaceutical compositions containing a compound of general formula (I), and to the therapeutic use of said compounds and compositions.
    Type: Grant
    Filed: July 2, 2008
    Date of Patent: November 30, 2010
    Assignee: sanofi-aventis
    Inventors: Pierre Perreaut, Samir Jegham, Bernard Bourrie, Pierre Casellas, Jean-Robert Labrosse, Florence Durand
  • 2-carbamide-4-phenylthiazole derivatives, preparation thereof and therapeutic use thereof
    Patent number: 7825112
    Abstract: The disclosure relates to 2-carbamide-4-phenylthiazole derivatives having the following general formula (I): wherein R1, R2, R3, Y and p are as defined in the disclosure. The disclosure also relates to pharmaceutical compositions containing a compound of formula (I), to processes for preparing the compounds of formula (I), and to methods of using the compounds of formula (I).
    Type: Grant
    Filed: June 26, 2008
    Date of Patent: November 2, 2010
    Assignee: sanofi-aventis
    Inventors: Pierre Casellas, Daniel Floutard, Pierre Fraisse, Stephane Hourcade, Samir Jegham
  • Pyridoindolone derivatives substituted in the 3-position by a heterocyclic group, their preparation and their application in therapeutics
    Patent number: 7816368
    Abstract: The present disclosure relates to pyridoindolone derivatives of general formula (I): in which R1 to R5 are as defined in the specification, to processes for preparing said derivatives, and to methods of use thereof.
    Type: Grant
    Filed: October 16, 2008
    Date of Patent: October 19, 2010
    Assignee: sanofi-aventis
    Inventors: Bernard Bourrie, Pierre Casellas, Jean-Marie Derocq, Samir Jegham, Yvette Muneaux
  • 6-substituted pyridoindolone derivatives, production and therapeutic use thereof
    Patent number: 7812165
    Abstract: Compounds of formula: and pharmaceutically acceptable salts, hydrates, and solvates thereof, wherein R1, R2, R3, R4, and R5, have the meanings given in the description; pharmaceutical compositions comprising said compounds; and processes for preparing said compounds and methods of use thereof.
    Type: Grant
    Filed: October 18, 2006
    Date of Patent: October 12, 2010
    Assignee: sanofi-aventis
    Inventors: Bernard Bourrie, Pierre Casellas, Paola Ciapetti, Jean-Marie Deroco, Samir Jegham, Yvette Muneaux, Camille-Georges Wermuth
  • NICOTINAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF
    Publication number: 20100222319
    Abstract: The disclosure relates to compounds of formula (I): wherein A, Z, Z?, L, R2 and R3 are as defined in the disclosure, to compositions comprising said compounds, and to methods for the manufacture and therapeutic use thereof.
    Type: Application
    Filed: March 26, 2010
    Publication date: September 2, 2010
    Applicant: SANOFI-AVENTIS
    Inventors: Claude BERNHART, Monsif BOUABOULA, Pierre CASELLAS, Samir JEGHAM, Jèrome ARIGON, Romain COMBET, Sandrine HILAIRET, Pierre FRAISSE
  • 2-acylamino-4-phenylthiazole derivatives, preparation thereof and therapeutic application thereof
    Patent number: 7777041
    Abstract: The invention relates to 2-acylamino-4-phenylthiazole derivatives of general formula (I): pharmaceutically acceptable acid-addition salts thereof, hydrates or solvates of such derivatives or such pharmaceutically acceptable acid addition salts, intermediates thereto, processes for the preparation thereof, and therapeutic application thereof.
    Type: Grant
    Filed: January 27, 2009
    Date of Patent: August 17, 2010
    Assignee: sanofi-aventis
    Inventors: Pierre Carayon, Pierre Casellas, Daniel Floutard, Pierre Fraisse, Samir Jegham, Bernard Labeeuw
  • 2-Carbamide-4-phenylthiazole derivatives, preparation thereof and therapeutic use thereof
    Patent number: 7767681
    Abstract: The disclosure concerns 2-carbamide-4-phenylthiazole derivatives of general formula (I). The disclosure also concerns pharmaceutical compositions containing a compound of general formula (I) and to processes for preparing and methods of using compounds of general formula (I).
    Type: Grant
    Filed: January 3, 2007
    Date of Patent: August 3, 2010
    Assignee: sanofi-aventis
    Inventors: Pierre Casellas, Daniel Floutard, Pierre Fraisse, Samir Jegham
  • 2-amido-4-phenylthiazole derivatives, the preparation and the therapeutic use thereof
    Patent number: 7598392
    Abstract: The disclosure relates to 2-amido-4-phenylthiazole derivatives of general formula (I) below: in which R1, R2, R3, Y, m, n, and p are as defined in the disclosure; as well as to their isomers, salts and solvates, to the pharmaceutical compositions containing them and to the therapeutic use thereof.
    Type: Grant
    Filed: April 18, 2007
    Date of Patent: October 6, 2009
    Assignee: sanofi-aventis
    Inventors: Pierre Casellas, Daniel Floutard, Pierre Fraisse, Samir Jegham
  • PYRIDO-PYRIMIDINE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF
    Publication number: 20090233923
    Abstract: The disclosure concerns pyrido[2,3-d]pyrimidine derivatives, their preparation and their therapeutic application, of general formula (I): and acid addition salts, hydrates and solvates thereof, as well as in the form of enantiomers, diastereoisomers and mixtures thereof. The disclosure also concerns methods for preparing said derivatives, pharmaceutical compositions containing a compound of general formula (I), and their therapeutic use.
    Type: Application
    Filed: March 31, 2009
    Publication date: September 17, 2009
    Applicant: Sanofi-aventis
    Inventors: Bernard Bourrie, Pierre Casellas, Samir Jegham, Pierre Perreaut
  • Derivatives of Pyrido[2,3-d]pyrimidine, the Preparation Thereof, and the Therapeutic Application of the Same
    Publication number: 20090163522
    Abstract: The invention relates to derivatives of pyrido[2,3-d]pyrimidine, to the preparation thereof, and to the therapeutic application of the same.
    Type: Application
    Filed: January 30, 2009
    Publication date: June 25, 2009
    Applicant: sanofi-aventis
    Inventors: Bernard BOURRIE, Pierre CASELLAS, Samir JEGHAM, Claude MUNEAUX, Pierre PERREAUT
  • 2-ACYLAMINO-4-PHENYLTHIAZOLE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC APPLICATION THEREOF
    Publication number: 20090156574
    Abstract: The invention relates to 2-acylamino-4-phenylthiazole derivatives of general formula (I): pharmaceutically acceptable acid-addition salts thereof, hydrates or solvates of such derivatives or such pharmaceutically acceptable acid addition salts, intermediates thereto, processes for the preparation thereof, and therapeutic application thereof.
    Type: Application
    Filed: January 27, 2009
    Publication date: June 18, 2009
    Applicant: SANOFI-AVENTIS
    Inventors: Pierre CARAYON, Pierre CASELLAS, Daniel FLOUTARD, Pierre FRAISSE, Samir JEGHAM, Bernard LABEEUW