Patents by Inventor Samir M. Hanash
Samir M. Hanash has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20130177927Abstract: Computerized analysis of 2-D gels, both carrier ampholyte (CA) and immobilized pH gradient (IPG) based, of the proteins in tissue from esophageal tumors, reveals proteins which are different in tumor and control tissue.Type: ApplicationFiled: October 12, 2006Publication date: July 11, 2013Inventors: Samir M. Hanash, David G. Beer, Rork Kuick, Robert Hinderer
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Publication number: 20120100558Abstract: Diagnosis of lung cancer in a subject before onset of symptoms is described herein (i.e., in a pre-diagnostic subject), by screening a biological fluid from the subject for the presence therein of autoantibodies that are specific for one or more pre-diagnostic lung cancer indicator proteins, including LAMR1, and optionally additionally or alternatively including annexin I and/or 14-3-3-theta and/or other pre-diagnostic lung cancer indicator proteins as presently disclosed, as the defined antigens. Related methods, including for monitoring immune reactivity against lung cancer indicator proteins in a lung cancer patient, typing lung cancer subjects or characterizing lung tumors, and application of the described proteomics approach for the identification of additional pre-diagnostic lung cancer indicator proteins, are also contemplated.Type: ApplicationFiled: August 27, 2009Publication date: April 26, 2012Inventors: Samir M. Hanash, Ji Qiu, Sandra Faca
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Patent number: 7955602Abstract: The present invention relates to screening methods for diagnosis, prognosis, or susceptibility to cancer in a subject by means of detecting the presence of serum autoantibodies to specific annexin protein antigens in sera from subjects. The present invention also provides screening methods for diagnosis and prognosis of cancer in a subject by means of detecting increased expression levels of annexin proteins in biological samples of the subject. The method of the invention can also be used to identify subjects at risk for developing cancer. The method of the invention involves the use of subject derived biological samples to determine the occurrence and level of expression of annexin proteins or expression of annexin derived peptides or antigens, and/or the occurrence and level of circulating autoantibodies to specific annexin protein antigens. The present invention further provides for kits for carrying out the above described screening methods.Type: GrantFiled: June 10, 2010Date of Patent: June 7, 2011Assignee: Regents of the University of MichiganInventors: Samir M. Hanash, David Misek, Robert Hinderer, David Beer, Frank Brichory
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Publication number: 20100330587Abstract: The present invention relates to screening methods for diagnosis, prognosis, or susceptibility to cancer in a subject by means of detecting the presence of serum autoantibodies to specific annexin protein antigens in sera from subjects. The present invention also provides screening methods for diagnosis and prognosis of cancer in a subject by means of detecting increased expression levels of annexin proteins in biological samples of the subject. The method of the invention can also be used to identify subjects at risk for developing cancer. The method of the invention involves the use of subject derived biological samples to determine the occurrence and level of expression of annexin proteins or expression of annexin derived peptides or antigens, and/or the occurrence and level of circulating autoantibodies to specific annexin protein antigens. The present invention further provides for kits for carrying out the above described screening methods.Type: ApplicationFiled: June 10, 2010Publication date: December 30, 2010Applicant: Regents of the University of MichiganInventors: Samir M. Hanash, David Misek, Robert Hinderer, David Beer, Franck Brichory
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Patent number: 7759081Abstract: The present invention relates to screening methods for diagnosis, prognosis, or susceptibility to cancer in a subject by means of detecting the presence of serum autoantibodies to specific annexin protein antigens in sera from subjects. The present invention also provides screening methods for diagnosis and prognosis of cancer in a subject by means of detecting increased expression levels of annexin proteins in biological samples of the subject. The method of the invention can also be used to identify subjects at risk for developing cancer. The method of the invention involves the use of subject derived biological samples to determine the occurrence and level of expression of annexin proteins or expression of annexin derived peptides or antigens, and/or the occurrence and level of circulating autoantibodies to specific annexin protein antigens. The present invention further provides for kits for carrying out the above described screening methods.Type: GrantFiled: June 21, 2006Date of Patent: July 20, 2010Assignee: Regents of the University of MichiganInventors: Samir M. Hanash, David Misek, Robert Hinderer, David Beer, Franck Brichory
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Publication number: 20100092476Abstract: The present invention provides a method of diagnosing, prognosing or screening for pancreatic cancer in a subject. The method may be carried out on a sample such as a blood or tissue sample collected from the subject. The is carried out by (a) detecting one or more markers in a biological sample of said subject, said markers selected from the markers set forth in Table 1 (e.g. one or more markers selected from the group set forth in Table 2, and/or the group consisting of ALCAM, TIMP-1, ICAM1, LCN2, REG1A, REG3, IGFBP4, TNFRSF1A and WFDC2); and (b) determining an altered level of said marker(s), said altered level indicating said subject may be afflicted with or at risk of developing pancreatic cancer. Kits useful for carrying out the methods are also described.Type: ApplicationFiled: November 14, 2007Publication date: April 15, 2010Inventors: Samir M. Hanash, Vitor M. Faca, Kenneth Song, Nabeel El-Bardeesy, Ronald A. DePinho
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Patent number: 7387881Abstract: The present invention relates to compositions and methods for cancer therapies and diagnostics, including but not limited to, cancer markers. In particular, the present invention provides tumor antigens associated with specific cancers and diagnostic assays for the detection of such antigens and associated autoantibodies as indicative of the presence of specific cancers. The present invention further provides cancer immunotherapy utilizing the tumor antigens of the present invention.Type: GrantFiled: September 16, 2002Date of Patent: June 17, 2008Assignee: The Regents of the University of MichiganInventors: Samir M. Hanash, Laura Beretta, Francois LeNaour
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Patent number: 7319010Abstract: The present invention relates to compositions and methods for cancer therapies and diagnostics, including but not limited to, cancer markers. In particular, the present invention provides tumor antigens associated with specific cancers and diagnostic assays for the detection of such antigens and associated autoantibodies as indicative of the presence of specific cancers. The present invention further provides cancer immunotherapy utilizing the tumor antigens of the present invention.Type: GrantFiled: May 12, 2004Date of Patent: January 15, 2008Assignee: The Regents of the University of MichiganInventors: Myeong Nam, Juan Madoz-Gurpide, Hong Wang, David E. Misek, Samir M. Hanash
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Patent number: 7202045Abstract: The present invention relates to compositions and methods for cancer therapies and diagnostics, including but not limited to, cancer markers. In particular, the present invention provides tumor antigens associated with specific cancers and diagnostic assays for the detection of such antigens and associated autoantibodies as indicative of the presence of specific cancers. The present invention further provides cancer immunotherapy utilizing the tumor antigens of the present invention.Type: GrantFiled: September 16, 2002Date of Patent: April 10, 2007Assignee: Regents of the University of MichiganInventors: Samir M. Hanash, Franck Brichory
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Publication number: 20040191841Abstract: The present invention relates to a method for identification of cellular protein antigens to which patients with cancer, or patients at risk for cancer, may develop autoantibodies. The method of the invention involves the use of patient derived sera for the identification of the cellular protein antigens using two-dimensional gel electrophoresis followed by Western Blot analysis. The identification of such protein antigens provides novel markers that can be utilized for screening, for diagnostics and prognosis of disease. The invention also provides for the use of the identified protein antigens in immunoassays designed to detect the presence of serum antibodies to the specific protein antigens in sera from individuals that may harbor such antibodies. The invention further relates to the use of the identified antigens as immunogens for stimulation of an immune response in patients expressing such protein antigens.Type: ApplicationFiled: September 29, 2003Publication date: September 30, 2004Inventors: Samir M. Hanash, David Misek, Robert Hinderer, Latha Prasannan
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Publication number: 20040137526Abstract: The present invention relates to systems, apparatuses and methods for multidimensional protein separation. In particular, the present invention relates to 3-dimension protein separation and characterization systems and methods.Type: ApplicationFiled: October 15, 2003Publication date: July 15, 2004Applicant: The Regents of the University of MichiganInventors: Samir M. Hanash, Hong Wang
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Publication number: 20040063120Abstract: The present invention relates to compositions and methods for cancer diagnostics, including but not limited to, cancer markers. In particular, the present invention provides gene expression profiles associated with lung cancers. Genes identified as cancer markers find use in the diagnosis and characterization of lung cancer. In addition, the genes provide targets for cancer drug screens and therapeutic applications.Type: ApplicationFiled: July 10, 2003Publication date: April 1, 2004Applicant: The Regents of the University of MichiganInventors: David G. Beer, Sharon Kardia, Thomas J. Giordano, Jeremy Taylor, Samir M. Hanash, Chiang-Ching Huang, David E. Misek, Dafydd Thomas, Rork Kuick
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Publication number: 20040048320Abstract: The present invention relates to screening methods for diagnosis, prognosis, or susceptibility to cancer in a subject by means of detecting the presence of serum autoantibodies to specific annexin protein antigens in sera from subjects. The present invention also provides screening methods for diagnosis and prognosis of cancer in a subject by means of detecting increased expression levels of annexin proteins in biological samples of the subject. The method of the invention can also be used to identify subjects at risk for developing cancer. The method of the invention involves the use of subject derived biological samples to determine the occurrence and level of expression of annexin proteins or expression of annexin derived peptides or antigens, and/or the occurrence and level of circulating autoantibodies to specific annexin protein antigens. The present invention further provides for kits for carrying out the above described screening methods.Type: ApplicationFiled: September 5, 2003Publication date: March 11, 2004Inventors: Samir M. Hanash, David Misek, Robert Hinderer, David Beer, Frank Brichory
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Patent number: 6680172Abstract: The present invention relates to novel cancer markers and compositions and methods for cancer therapies. For example, the present invention provides compositions and methods for the detection of gene expression of particular marker genes as indicative of cancers, while control of said gene expression provides for intervention in cancer therapies and, in particular, glioma therapies.Type: GrantFiled: May 16, 2000Date of Patent: January 20, 2004Assignee: Regents of the University of MichiganInventors: Samir M. Hanash, David Rickman, Rachana Tyagi, Xiao-Xiang Zhu, Phillip Kish
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Publication number: 20040010126Abstract: The present invention relates to multiphase protein separation methods capable of resolving large numbers of cellular proteins. The methods of the present invention provide protein profile maps for imaging and comparing protein expression patterns. The present invention provides alternatives to traditional 2-D gel separation methods for the screening of protein profiles.Type: ApplicationFiled: October 1, 2001Publication date: January 15, 2004Applicant: The Regents of the University of MichiganInventors: David M. Lubman, Timothy J. Barder, Daniel B. Wall, Stephen J. Parus, Maureen T. Kachman, Bathsheba E. Chong, Samir M. Hanash, David E. Misek, Robert Hinderer
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Patent number: 6677128Abstract: The present invention relates to a method for identification of cellular protein antigens to which patients with cancer, or patients at risk for cancer, may develop autoantibodies. The method of the invention involves the use of patient derived sera for the identification of the cellular protein antigens using two-dimensional gel electrophoresis followed by Western Blot analysis. The identification of such protein antigens provides novel markers that can be utilized for screening, for diagnostics and prognosis of disease. The invention also provides for the use of the identified protein antigens in immunoassays designed to detect the presence of serum antibodies to the specific protein antigens in sera from individuals that may harbor such antibodies. The invention further relates to the use of the identified antigens as immunogens for stimulation of an immune response in patients expressing such protein antigens.Type: GrantFiled: December 16, 1999Date of Patent: January 13, 2004Assignee: Regents of the University of MichiganInventors: Samir M. Hanash, David Misek, Robert Hinderer, Latha Prasannan
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Publication number: 20040005645Abstract: Computerized analysis of 2-D gels, both carrier ampholyte (CA) and immobilized pH gradient (IPG) based, of the proteins in tissue from esophageal tumors, reveals proteins which are different in tumor and control tissue.Type: ApplicationFiled: March 24, 2003Publication date: January 8, 2004Applicant: The Regents of the University of MichiganInventors: Samir M. Hanash, David G. Beer, Rork Kuick, Robert Hinderer
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Patent number: 6645465Abstract: The present invention relates to screening methods for diagnosis, prognosis, or susceptibility to cancer in a subject by means of detecting the presence of serum autoantibodies to specific annexin protein antigens in sera from subjects. The present invention also provides screening methods for diagnosis and prognosis of cancer in a subject by means of detecting increased expression levels of annexin proteins in biological samples of the subject. The method of the invention can also be used to identify subjects at risk for developing cancer. The method of the invention involves the use of subject derived biological samples to determine the occurrence and level of expression of annexin proteins or expression of annexin derived peptides or antigens, and/or the occurrence and level of circulating autoantibodies to specific annexin protein antigens. The present invention further provides for kits for carrying out the above described screening methods.Type: GrantFiled: August 6, 1999Date of Patent: November 11, 2003Assignee: Michigan, University of the RegentsInventors: Samir M. Hanash, David Misek, Robert Hinderer, David Beer, Franck Brichory
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Publication number: 20030119079Abstract: The present invention relates to compositions and methods for cancer therapies and diagnostics, including but not limited to, cancer markers. In particular, the present invention provides tumor antigens associated with specific cancers and diagnostic assays for the detection of such antigens and associated autoantibodies as indicative of the presence of specific cancers. The present invention further provides cancer immunotherapy utilizing the tumor antigens of the present invention.Type: ApplicationFiled: September 16, 2002Publication date: June 26, 2003Applicant: The Regents of the University of MichiganInventors: Samir M. Hanash, Francois LeNaour, David Misek, Melissa Krause
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Publication number: 20030108553Abstract: The present invention relates to compositions and methods for cancer therapies and diagnostics, including but not limited to, cancer markers. In particular, the present invention provides tumor antigens associated with specific cancers and diagnostic assays for the detection of such antigens and associated autoantibodies as indicative of the presence of specific cancers. The present invention further provides cancer immunotherapy utilizing the tumor antigens of the present invention.Type: ApplicationFiled: September 16, 2002Publication date: June 12, 2003Applicant: The Regents of the University of MichiganInventors: Samir M. Hanash, Laura Beretta, Francois LeNaour