Abstract: The present invention relates to the discovery that the expression levels of some RNA molecules, comprising messenger RNA (mRNA), non-coding RNA (ncRNA) and/or microRNA (miRNA), and protein can be used as a diagnostic signature to predict or monitor the bone healing ability in an acutely injured subject or in a chronic nonunion subject. In certain embodiments, the invention relates to methods and compositions useful for differentiating between a nonunion, slow healing, and/or normal healing of a fractured bone and treatment recommendations. The invention further includes a kit comprising biomarker probes for assessing the bone healing ability in an acutely injured subject or in a nonunion subject after receiving therapeutic treatment.

Abstract: Periprosthetic bone fixation plates are disclosed including, for example, periprosthetic proximal femur plate, periprosthetic distal femur plate, periprosthetic humerus plate, periprosthetic ring plate, and periprosthetic troch plate. In use, the periprosthetic bone fixation plates are arranged and configured for use in periprosthetic fractures. That is, the periprosthetic plates include one or more features to facilitate positioning and securement of the bone fixation plate to a patient's bone that previously received a surgically implanted orthopedic device or implant such as, for example, an intramedullary nail, a hip prosthesis, a knee prosthesis, etc. In use, the one or more features are designed and configured to facilitate avoidance of the previous surgically implanted orthopedic device or implant. In addition, the periprosthetic bone fixation plates are arranged and configured to facilitate plating of a longer working length as compared to existing bone fixation plates (e.g.

Abstract: Periprosthetic bone fixation plates are disclosed including, for example, periprosthetic proximal femur plate, periprosthetic distal femur plate, periprosthetic humerus plate, periprosthetic ring plate, and periprosthetic troch plate. In use, the periprosthetic bone fixation plates are arranged and configured for use in periprosthetic fractures. That is, the periprosthetic plates include one or more features to facilitate positioning and securement of the bone fixation plate to a patients bone that previously received a surgically implanted orthopedic device or implant such as, for example, an intramedullary nail, a hip prosthesis, a knee prosthesis, etc. In use, the one or more features are designed and configured to facilitate avoidance of the previous surgically implanted orthopedic device or implant. In addition, the periprosthetic bone fixation plates are arranged and configured to facilitate plating of a longer working length as compared to existing bone fixation plates (e.g.

Abstract: A surgical navigation system includes an extended reality head-mountable display (HMD). The surgical navigation system further includes a computer system comprising at least one processor, wherein the computer system is configured for performing operations. The operations include receiving camera images while a surgeon is wearing the HMD and performing a surgical procedure on a subject. The operations further include identifying at least one image feature depicted in the images. The operations further include tracking a location of at least one surgical object using the image feature. The operations further include sending one or more visual indicators to the HMD to display, to the surgeon, a target location for the surgical object for the surgical procedure. The target location includes a location external to the subject for the surgeon to use the surgical object to perform the surgical procedure on the subject.

Abstract: A bone plate incorporating a length adjusting elongate hole formed in a shaft portion thereof, along with corresponding methods of use. In one embodiment, the length adjusting elongate hole is configured to receive one or more bone fixation devices (e.g., bone screws). The bone fixation device positioned within the length adjusting elongate hole may be partially loosened, without removal, to enable the patient's bone to be adjusted (e.g., loosening the bone fixation device within the length adjusting elongate hole allows the surgeon to adjust the position of the patient's bone, and hence the bone fixation device coupled thereto, relative to the bone plate). Once properly adjusted, the bone fixation device positioned within the length adjusting elongate hole may be retightened. In various embodiments, the length adjusting elongate hole is arranged and configured so that, in use, each of the plurality of bone fixation openings remains available to a surgeon.

Abstract: A bone plate incorporating a length adjusting elongate hole formed in a shaft portion thereof, along with corresponding methods of use. In one embodiment, the length adjusting elongate hole is configured to receive one or more bone fixation devices (e.g., bone screws). In use, the bone fixation device positioned within the length adjusting elongate hole may be partially loosened, without removal, to enable the patient's bone to be adjusted (e.g., loosening the bone fixation device within the length adjusting elongate hole allows the surgeon to adjust the position of the patient's bone, and hence the bone fixation device coupled thereto, relative to the bone plate). Once properly adjusted, the bone fixation device positioned within the length adjusting elongate hole may be retightened. In various embodiments, the length adjusting elongate hole is configured so that, in use, each of the plurality of bone fixation openings remains available to a surgeon.

Abstract: In example embodiments, a system and method for managing the resale of digital media rights is provided. In example embodiments, user accounts that store digital media rights for digital content may be maintained. An indication that a first user having a first user account intends to transfer digital media rights for a particular digital content may is received. A verification process is performed to verify that the digital media rights of the first user are transferable. Based on an indication that a transaction has occurred, the digital media rights are transferred from the first user account to a second user account associated with a second user that is a recipient of the digital media rights.

Abstract: Disclosed herein are systems, methods, and software for providing a platform for artificial intelligence-assisted image analysis.

Abstract: In example embodiments, a system and method for managing the resale of digital media rights is provided. In example embodiments, user accounts that store digital media rights for digital content may be maintained. An indication that a first user having a first user account intends to transfer digital media rights for a particular digital content may is received. A verification process is performed to verify that the digital media rights of the first user are transferable. Based on an indication that a transaction has occurred, the digital media rights are transferred from the first user account to a second user account associated with a second user that is a recipient of the digital media rights.

Abstract: A bone plate incorporating a length adjusting elongate hole formed in a shaft portion thereof, along with corresponding methods of use. In one embodiment, the length adjusting elongate hole is configured to receive one or more bone fixation devices (e.g., bone screws). In use, the bone fixation device positioned within the length adjusting elongate hole may be partially loosened, without removal, to enable the patient's bone to be adjusted (e.g., loosening the bone fixation device within the length adjusting elongate hole allows the surgeon to adjust the position of the patient's bone, and hence the bone fixation device coupled thereto, relative to the bone plate). Once properly adjusted, the bone fixation device positioned within the length adjusting elongate hole may be retightened. In various embodiments, the length adjusting elongate hole is configured so that, in use, each of the plurality of bone fixation openings remains available to a surgeon.

Abstract: The present invention relates to the discovery that the expression levels of some RNA molecules, comprising messenger RNA (mRNA), non-coding RNA (ncRNA) and/or microRNA (miRNA), and protein can be used as a diagnostic signature to predict or monitor the bone healing ability in an acutely injured subject or in a chronic nonunion subject. In certain embodiments, the invention relates to methods and compositions useful for differentiating between a nonunion, slow healing, and/or normal healing of a fractured bone and treatment recommendations. The invention further includes a kit comprising biomarker probes for assessing the bone healing ability in an acutely injured subject or in a nonunion subject after receiving therapeutic treatment.

Abstract: A blockchain platform is provided for creating original non-fungible tokens (NFTs) and prints of the original NFTs. The platform creates a market for purchasing and selling prints of the original NFTs. The purchase price and the sale price for a print is determined based on a bonding curve and a total supply of the prints of the original NFT. The platform may also generate content (e.g., artwork and/or music) associated with the original NFTs. The content may be generated from logic that is stored on the blockchain.

Abstract: Periprosthetic bone fixation plates are disclosed including, for example, periprosthetic proximal femur plate, periprosthetic distal femur plate, periprosthetic humerus plate, periprosthetic ring plate, and periprosthetic troch plate. In use, the periprosthetic bone fixation plates are arranged and configured for use in periprosthetic fractures. That is, the periprosthetic plates include one or more features to facilitate positioning and securement of the bone fixation plate to a patients bone that previously received a surgically implanted orthopedic device or implant such as, for example, an intramedullary nail, a hip prosthesis, a knee prosthesis, etc. In use, the one or more features are designed and configured to facilitate avoidance of the previous surgically implanted orthopedic device or implant. In addition, the periprosthetic bone fixation plates are arranged and configured to facilitate plating of a longer working length as compared to existing bone fixation plates (e.g.

Abstract: A blockchain platform is provided for creating original non-fungible tokens (NFTs) and prints of the original NFTs. The platform creates a market for purchasing and selling prints of the original NFTs. The purchase price and the sale price for a print is determined based on a bonding curve and a total supply of the prints of the original NFT. The platform may also generate content (e.g., artwork and/or music) associated with the original NFTs. The content may be generated from logic that is stored on the blockchain.

Abstract: The present invention relates to the discovery that the expression levels of some RNA molecules, comprising messenger RNA (mRNA), non-coding RNA (ncRNA) and/or microRNA (miRNA), and protein can be used as a diagnostic signature to predict or monitor the bone healing ability in an acutely injured subject or in a chronic nonunion subject. In certain embodiments, the invention relates to methods and compositions useful for differentiating between a nonunion, slow healing, and/or normal healing of a fractured bone and treatment recommendations. The invention further includes a kit comprising biomarker probes for assessing the bone healing ability in an acutely injured subject or in a nonunion subject after receiving therapeutic treatment.

Abstract: In example embodiments, a system and method for managing the resale of digital media rights is provided. In example embodiments, user accounts that store digital media rights for digital content may be maintained. An indication that a first user having a first user account intends to transfer digital media rights for a particular digital content may is received. A verification process is performed to verify that the digital media rights of the first user are transferable. Based on an indication that a transaction has occurred, the digital media rights are transferred from the first user account to a second user account associated with a second user that is a recipient of the digital media rights.

Abstract: In example embodiments, a system and method for managing the resale of digital media rights is provided. In example embodiments, user accounts that store digital media rights for digital content may be maintained. An indication that a first user having a first user account intends to transfer digital media rights for a particular digital content may is received. A verification process is performed to verify that the digital media rights of the first user are transferable. Based on an indication that a transaction has occurred, the digital media rights are transferred from the first user account to a second user account associated with a second user that is a recipient of the digital media rights.

Abstract: An improved user premises device enhances the channel change experience. In response to a channel-up or a channel-down command, a currently displayed program is re-sized to fit within a smaller program window. In the display area that is exposed due to the re-sizing of the currently displayed program, additional content such as an advertisement or channel change progress information is displayed. Additional program windows that render snapshots of content from one or more program up and one or more program down may be displayed in windows that are organized in a vertical alignment with the program window of the currently displayed program. The program windows are animated or scrolled in a direction to bring the program window of the user-desired next program in place of the program window of the currently displayed programmed. The program window of the next program is then resized to occupy the entire display.

Abstract: An improved user premises device enhances the channel change experience. In response to a channel-up or a channel-down command, a currently displayed program is re-sized to fit within a smaller program window. In the display area that is exposed due to the re-sizing of the currently displayed program, additional content such as an advertisement or channel change progress information is displayed. Additional program windows that render snapshots of content from one or more program up and one or more program down may be displayed in windows that are organized in a vertical alignment with the program window of the currently displayed program. The program windows are animated or scrolled in a direction to bring the program window of the user-desired next program in place of the program window of the currently displayed programmed. The program window of the next program is then resized to occupy the entire display.

Abstract: An improved user premises device enhances the channel change experience. In response to a channel-up or a channel-down command, a currently displayed program is re-sized to fit within a smaller program window. In the display area that is exposed due to the re-sizing of the currently displayed program, additional content such as an advertisement or channel change progress information is displayed. Additional program windows that render snapshots of content from one or more program up and one or more program down may be displayed in windows that are organized in a vertical alignment with the program window of the currently displayed program. The program windows are animated or scrolled in a direction to bring the program window of the user-desired next program in place of the program window of the currently displayed programmed. The program window of the next program is then resized to occupy the entire display.