Abstract: The invention relates to a process for producing medicaments which comprise HMG CoA reductase inhibitors in the form of their salts, characterized in that the corresponding precursors of the actual active compounds are converted with bases, which contain alkali metal or alkaline earth metal ions, in a solvent, into the active compound, and the resulting active compound-containing solution is processed into the desired administration form.

Abstract: The invention relates to a process for producing medicaments which comprise HMG CoA reductase inhibitors in the form of their salts, characterized in that the corresponding precursors of the actual active compounds are converted with bases, which contain alkali metal or alkaline earth metal ions, in a solvent, into the active compound, and the resulting active compound-containing solution is processed into the desired administration form.

Abstract: The invention relates to new ?3-amino!-tetrahydrocarbazole-propanoic acid esters which can be used as intermediates for the preparation of known thromboxane-antagonistic active compounds, and to a method for the purification of these active compounds.

Abstract: The present invention relates to 3-substituted quinoline-5-carboxylic acid derivatives and processes for their preparation.

Abstract: The new compounds of the formula ##STR1## in which Acyl is alkylcarbonyl optionally substituted by halogen or aryl, or arylcarbonyl, which is substituted by lower alkoxy, halogen or nitro,R.sup.1 is an alkyl or alkenyl radical, andR.sup.4 is an optionally substituted branched or straight-chain C.sub.1 -C.sub.6 -alkyl radical or a cycloalkyl radical,are produced by reacting a 2-halogenoacetylacrylic acid ester of the formula ##STR2## with an acylthiourea of the formula ##STR3## The reaction can be conducted in aqueous DMF, substantially pure Z-isomer selectively crystallizing out.

Abstract: The new indole derivatives of the formula ##STR1## in which R.sup.1 and R.sup.2 are identical or different and denote hydrogen or lower alkyl,R.sup.3 denotes hydrogen, lower alkyl or halogen andR.sup.4 and R.sup.5 are identical or different and denote hydrogen, lower alkyl or optionally substituted aryl, and R.sup.4 and R.sup.5 can also represent lower alkenyl, andwhereinR.sup.2 and R.sup.5 can be linked by an alkylene bridge of the formula--CH.sub.2 --CH.sub.2 --CH.sub.2).sub.nin whichn represents the number 0 or 1, can be prepared by reacting an ammonium or phosphonium salt of the corresponding indolecarboxylic acid with a haloacetic acid allyl ester. The new compounds can be used to prepare acemetacin. The new indole derivatives possess a pharmacological action.

Abstract: Acemetacin is prepared by reaction of an indometacin with tert.-butyl halogenoacetate and subsequent cleavage with sulphuric acid and/or sulphonic acid.

Abstract: The invention relates to an improved process for the isolation and purification of aminoglycoside antibiotics of Formula (I) as defined herein combining selective lipophilization of the compound of Formula (I) in the crude product obtained by fermentation with controlled liquid/liquid extraction.