Patents by Inventor Samir Yahiaoui

Samir Yahiaoui has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PqsR inverse agonists
    Patent number: 11883387
    Abstract: The present invention relates to a compound according to general formula (I), which acts as an inhibitor of PqsR (the currently only known receptor for the Pseudomonas Quinolone Signal (PQS)); to a pharmaceutical composition containing one or more of the compound(s) of the invention; to a combination preparation containing at least one compound of the invention and at least one further active pharmaceutical ingredient; and to uses of said compound(s), including the use as a medicament, e.g. the use in the treatment or prophylaxis of a bacterial infection, especially a Pseudomonas aeruginosa or Burkholderia infection.
    Type: Grant
    Filed: July 3, 2019
    Date of Patent: January 30, 2024
    Assignee: Helmholtz-Zentrum Für Infektionsforschung GmbH
    Inventors: Ahmed S. A. Ahmed, Martin Empting, Mostafa Hamed, Rolf W. Hartmann, Jörg Haupenthal, Thomas Hesterkamp, Ahmed A. M. Kamal, Christine K. Maurer, Teresa Röhrig, Christian Schütz, Samir Yahiaoui, Michael Zender
  • INHIBITORS OF PSEUDOMONAS AERUGINOSA VIRULENCE FACTOR LasB
    Publication number: 20230321123
    Abstract: The present invention relates to compounds of formula (Ia) and the use thereof as inhibitors of P. aeruginosa virulence factor LasB. Formula (Ia). These compounds are useful in the treatment of bacterial infections, especially caused by P. aeruginosa.
    Type: Application
    Filed: August 24, 2021
    Publication date: October 12, 2023
    Inventors: Christian Ducho, Rolf W. Hartmann, Jörg Haupenthal, Anna K. H. Hirsch, Andreas Kany, Cansu Kaya, Jelena Konstantinovic, Katrin Voos, Isabell Walter, Samir Yahiaoui, Ahmed Saad Abdelsamine, Christian Schütz, Ravindra Jumde, Alexander Kiefer
  • N-PHENYL-3-MERCAPTOPROPANAMIDE DERIVATIVES AS METALLO-BETA-LACTAMASE INHIBITORS FOR THE TREATMENT OF BACTERIAL INFECTIONS
    Publication number: 20230146507
    Abstract: The present invention related to novel inhibitors of metallo-?3-lactamases of formula (I) wherein R1 is an optionally substituted aryl group of an optionally substituted heteroaryl group, and the use thereof in the treatment of bacterial infections, especially in combination with ?-lactam antibiotics.
    Type: Application
    Filed: March 23, 2021
    Publication date: May 11, 2023
    Inventors: Rolf W. Hartmann, Jelena Konstantinovic, Jörg Haupenthal, Anna K. Hirsch, Andreas M. Kany, Cansu Kaya, Samir Yahiaoui, Thomas Wichelhaus, Eugen Proschak
  • PqsR INVERSE AGONISTS
    Publication number: 20210353606
    Abstract: The present invention relates to a compound according to general formula (I), which acts as an inhibitor of PqsR (the currently only known receptor for the Pseudomonas Quinolone Signal (PQS)); to a pharmaceutical composition containing one or more of the compound(s) of the invention; to a combination preparation containing at least one compound of the invention and at least one further active pharmaceutical ingredient; and to uses of said compound(s), including the use as a medicament, e.g. the use in the treatment or prophylaxis of a bacterial infection, especially a Pseudomonas aeruginosa or Burkholderia infection.
    Type: Application
    Filed: July 3, 2019
    Publication date: November 18, 2021
    Inventors: Ahmed S.A. Ahmed, Martin Empting, Mostafa Hamed, Rolf W. Hartmann, Jörg Haupenthal, Thomas Hesterkamp, Ahmed A.M. Kamal, Christine K. Maurer, Teresa Röhrig, Christian Schütz, Samir Yahiaoui, Michael Zender