Abstract: A spray drier monitoring and control system is provided for a spray drier device adapted to spray dry a liquid sample such as blood plasma. The system may receive information regarding an operator of the device, the liquid sample, a spray drier assembly used by the device for spray drying, and spray drying process parameters. The spray drier system may also conduct a plurality of checks to ensure that traceability and conformance with attendant quality/safety standards are maintained throughout the spray drying process. The information may be output by the system to a remote computing device (e.g., a blood center computing system) that tracks the sample history. Beneficially, the spray drier system allows information regarding spray drying to be easily integrated with the sample information for enhanced tracking and quality control of the sample.