Patents by Inventor Samira M. Azarin

Samira M. Azarin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11980410
    Abstract: A device includes an electrically conductive or electrically semiconductive material and a biocompatible porous scaffold around the electrically conductive or electrically semiconductive material. The biocompatible porous scaffold includes a biocompatible polymer and pores configured to capture metastatic cells.
    Type: Grant
    Filed: October 5, 2018
    Date of Patent: May 14, 2024
    Assignee: Regents of the University of Minnesota
    Inventors: Samira M. Azarin, Francisco Pelaez, Navid Manuchehrabadi, John C. Bischof
  • Publication number: 20230063616
    Abstract: The disclosure relates to a biosensor on the bacterial cell surface for sensing and responding to extracellular molecules. Related methods of using the bacterial cells to inducibly express a protein of interest and/or a bioactive RNA molecule in a subject are disclosed. Related methods of using the bacterial cells to inducibly express a protein of interest or to detect a target of interest in a sample are also disclosed.
    Type: Application
    Filed: August 10, 2022
    Publication date: March 2, 2023
    Inventors: Casim A. Sarkar, Samira M. Azarin, Qiuge Zhang
  • Publication number: 20220125953
    Abstract: Provided herein are synthetic scaffolds engineered to function as a pre-metastatic niche to detect metastasis. In particular, synthetic scaffolds described herein provide detection of the earliest events in metastasis, thereby enabling treatment of metastasis before the disease burden increases.
    Type: Application
    Filed: November 1, 2021
    Publication date: April 28, 2022
    Inventors: Lonnie D. Shea, Samira M. Azarin, Robert M. Gower, Jacqueline Jeruss
  • Patent number: 10590393
    Abstract: In one embodiment, the present invention is a method of creating a fully-human blood-brain barrier (BBB) model, comprising the steps of (a) obtaining a mixture of neural cells and brain microvascular endothelial cells (BMECs), wherein the neural cells and BMECs that comprise the mixture were produced from the differentiation of human pluripotent stem cells (hPSCs); (b) purifying BMECs from the mixture of neural cells and BMECs of step (a); and (c) co-culturing the purified BMECs with a cell type selected from the group consisting of pericytes, astrocytes and differentiated neural progenitor cells (NPCs), wherein a blood brain barrier model is created.
    Type: Grant
    Filed: March 11, 2013
    Date of Patent: March 17, 2020
    Assignee: WISCONSIN ALUMNI RESEARCH FOUNDATION
    Inventors: Eric V. Shusta, Sean P. Palecek, Ethan S. Lippmann, Samira M. Azarin
  • Publication number: 20190388564
    Abstract: Provided herein are synthetic scaffolds engineered to function as a pre-metastatic niche to detect metastasis. In particular, synthetic scaffolds described herein provide detection of the earliest events in metastasis, thereby enabling treatment of metastasis before the disease burden increases.
    Type: Application
    Filed: January 7, 2019
    Publication date: December 26, 2019
    Inventors: Lonnie D. Shea, Samira M. Azarin, Robert M. Gower, Jacqueline Jeruss
  • Publication number: 20190105094
    Abstract: A device includes an electrically conductive or electrically semiconductive material and a biocompatible porous scaffold around the electrically conductive or electrically semiconductive material. The biocompatible porous scaffold includes a biocompatible polymer and pores configured to capture metastatic cells.
    Type: Application
    Filed: October 5, 2018
    Publication date: April 11, 2019
    Inventors: Samira M. Azarin, Francisco Pelaez, Navid Manuchehrabadi, John C. Bischof
  • Publication number: 20170281798
    Abstract: Provided herein are synthetic scaffolds engineered to function as a pre-metastatic niche to detect metastasis. In particular, synthetic scaffolds described herein provide detection of the earliest events in metastasis, thereby enabling treatment of metastasis before the disease burden increases.
    Type: Application
    Filed: April 14, 2017
    Publication date: October 5, 2017
    Inventors: Lonnie D. Shea, Samira M. Azarin, Robert M. Gower, Jacqueline Jeruss
  • Publication number: 20140127800
    Abstract: In one embodiment, the present invention is a method of creating a fully-human blood-brain barrier (BBB) model, comprising the steps of (a) obtaining a mixture of neural cells and brain microvascular endothelial cells (BMECs), wherein the neural cells and BMECs that comprise the mixture were produced from the differentiation of human pluripotent stem cells (hPSCs); (b) purifying BMECs from the mixture of neural cells and BMECs of step (a); and (c) co-culturing the purified BMECs with a cell type selected from the group consisting of pericytes, astrocytes and differentiated neural progenitor cells (NPCs), wherein a blood brain barrier model is created.
    Type: Application
    Filed: March 11, 2013
    Publication date: May 8, 2014
    Applicant: WISCONSIN ALUMNI RESEARCH FOUNDATION
    Inventors: Eric V. Shusta, Sean P. Palecek, Ethan S. Lippmann, Samira M. Azarin
  • Publication number: 20140072510
    Abstract: Provided herein are synthetic scaffolds engineered to function as a pre-metastatic niche to detect metastasis. In particular, synthetic scaffolds described herein provide detection of the earliest events in metastasis, thereby enabling treatment of metastasis before the disease burden increases.
    Type: Application
    Filed: March 15, 2013
    Publication date: March 13, 2014
    Inventors: Lonnie D. Shea, Samira M. Azarin, Robert M. Gower, Jacqueline Jeruss