Patents by Inventor Samson Chen

Samson Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11109784
    Abstract: Measurement of target analytes is carried out with an enzyme-based sensor. The enzyme hydrogel is protected by a porous layer of a metallic material. The size of the pores is small enough to prevent degradation of the enzyme layer caused by the immune system of an organism, but large enough to allow transfer of molecules that participate in the electrochemical reaction allowing the enzyme to detect the target analytes.
    Type: Grant
    Filed: November 14, 2018
    Date of Patent: September 7, 2021
    Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Dvin Adalian, Samson Chen, Muhammad M. Jilani, Axel Scherer, Xiomara Linnette Madero, Richard Smith
  • Patent number: 11026610
    Abstract: A sensor implanted in tissues and including a sensing layer is fabricated by mixing the signal transduction enzyme with non-reactive components including buffer salts and fillers, and spin coating the enzyme onto a substrate. The signal transduction enzyme is crosslinked by introducing the coated substrate in a vacuum chamber. In the chamber, a crosslinker evaporates and is deposited onto the enzyme, therefore crosslinking the enzyme.
    Type: Grant
    Filed: September 27, 2018
    Date of Patent: June 8, 2021
    Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Samson Chen, Axel Scherer, Dvin Adalian, Peter Petillo, Muhammad Musab Jilani, Xiomara L. Madero, Deepan Kishore Kumar
  • Patent number: 10996185
    Abstract: A cycle of positive and negative voltage pulses applied to an electrode sensor removes passivation of an electrode surface. The conditioned sensors have improved sensitivity to concentrations for analytes of interest. The electrode surfaces can also be passivated on purpose to reduce sensitivity. The voltages applied are varied according to the solution present.
    Type: Grant
    Filed: May 22, 2017
    Date of Patent: May 4, 2021
    Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Samson Chen, Axel Scherer, Muhammad M. Jilani
  • Publication number: 20190307378
    Abstract: Measurement of target analytes is carried out with an enzyme-based sensor. The enzyme hydrogel is protected by a porous layer of a metallic material. The size of the pores is small enough to prevent degradation of the enzyme layer caused by the immune system of an organism, but large enough to allow transfer of molecules that participate in the electrochemical reaction allowing the enzyme to detect the target analytes.
    Type: Application
    Filed: November 14, 2018
    Publication date: October 10, 2019
    Inventors: Dvin ADALIAN, Samson CHEN, Muhammad M. JILANI, Axel SCHERER, Xiomara Linnette MADERO, Richard SMITH
  • Patent number: 10376892
    Abstract: PC board fluidic devices for performing a Polymerase Chain Reaction (PCR) are disclosed. The devices comprise a printed circuit board and a PCR chamber. The PCR chamber is a fluidic chamber and is located in, or is part of, the PC board. The PC board can include a coil trace heating element with a temperature sensor and controller.
    Type: Grant
    Filed: November 23, 2016
    Date of Patent: August 13, 2019
    Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Aditya Rajagopal, Samson Chen, Axel Scherer, Christopher I. Walker
  • Publication number: 20190090797
    Abstract: A sensor implanted in tissues and including a sensing enzyme takes an electrical measurement and compares it to reference curves for the voltage current relationship. The sensor determines whether molecular compounds are present which interfere with the detection of the molecule of interest. If interfering species are found, the measurement voltage is set in a low range to reduce errors, while if the interfering species are not found, the measurement voltage is set in a high range to increase the detected signal.
    Type: Application
    Filed: September 27, 2018
    Publication date: March 28, 2019
    Inventors: Samson CHEN, Axel SCHERER
  • Publication number: 20190090796
    Abstract: A sensor implanted in tissues and including a sensing layer is fabricated by mixing the signal transduction enzyme with non-reactive components including buffer salts and fillers, and spin coating the enzyme onto a substrate. The signal transduction enzyme is crosslinked by introducing the coated substrate in a vacuum chamber. In the chamber, a crosslinker evaporates and is deposited onto the enzyme, therefore crosslinking the enzyme.
    Type: Application
    Filed: September 27, 2018
    Publication date: March 28, 2019
    Inventors: Samson CHEN, Axel SCHERER
  • Publication number: 20190060218
    Abstract: An implantable device contains a drug or biosensing compound, protected from the external environment within a human body by several barriers which are broken upon activation of the device through electrothermal, chemical, and mechanical processes. The device allows accurate and repeated dosing within a human body, thus reducing the number of implantation procedures required. This device extends the lifetime of a biosensor, reducing the number of implantation procedures required.
    Type: Application
    Filed: July 24, 2018
    Publication date: February 28, 2019
    Inventors: Samson CHEN, Axel SCHERER, Richard Daniel SMITH, JR.
  • Publication number: 20180338681
    Abstract: A smart cage includes radiofrequency transceivers and tags attached to laboratory animals. The tags include sensors to detect monitorable conditions of the laboratory animals. The sensors include working electrodes, counter electrodes, reference electrodes, and potentiostats. The top surface of the electrodes is coated with ionophores or enzymes which detect the monitorable conditions of the laboratory animals.
    Type: Application
    Filed: May 23, 2018
    Publication date: November 29, 2018
    Inventors: Axel SCHERER, Peter A. PETILLO, Samson CHEN, Azita EMAMI
  • Publication number: 20170336340
    Abstract: A cycle of positive and negative voltage pulses applied to an electrode sensor removes passivation of an electrode surface. The conditioned sensors have improved sensitivity to concentrations for analytes of interest. The electrode surfaces can also be passivated on purpose to reduce sensitivity. The voltages applied are varied according to the solution present.
    Type: Application
    Filed: May 22, 2017
    Publication date: November 23, 2017
    Inventors: Samson CHEN, Axel SCHERER, Muhammad M. JILANI
  • Patent number: 9606060
    Abstract: A device and method are described in which the lifetime of a fluorescent species or fluorophores is detected in the absence of any optical filter. Based on the measured fluorescent lifetimes, molecules or compounds attached to a fluorophores such as small organic molecules, polymers, peptides, saccharides and nucleic acids can be identified or assayed.
    Type: Grant
    Filed: January 11, 2013
    Date of Patent: March 28, 2017
    Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Samson Chen, Aditya Rajagopal, Axel Scherer
  • Publication number: 20170072399
    Abstract: PC board fluidic devices for performing a Polymerase Chain Reaction (PCR) are disclosed. The devices comprise a printed circuit board and a PCR chamber. The PCR chamber is a fluidic chamber and is located in, or is part of, the PC board. The PC board can include a coil trace heating element with a temperature sensor and controller.
    Type: Application
    Filed: November 23, 2016
    Publication date: March 16, 2017
    Inventors: Aditya RAJAGOPAL, Samson CHEN, Axel SCHERER, Christopher I. WALKER
  • Patent number: 9533308
    Abstract: An apparatus for performing a Polymerase Chain Reaction (PCR) is disclosed. The apparatus comprises a PCR chamber for performing a Polymerase Chain Reaction and a printed circuit board (PCB) fluidic device. The PCR chamber is a fluidic chamber and is located in, or is part of, the printed circuit board (PCB) fluidic device. A method for manufacturing an apparatus for performing the Polymerase Chain Reaction and a method for performing the Polymerase Chain Reaction are further disclosed.
    Type: Grant
    Filed: February 8, 2013
    Date of Patent: January 3, 2017
    Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Aditya Rajagopal, Samson Chen, Axel Scherer, Christopher I. Walker
  • Patent number: 9238833
    Abstract: Novel methods and systems for polymerase chain reaction (PCR) are disclosed. A PCR device has a bottom heater layer, a central reacting layer, and a top heater layer. The central reacting layer has a PCR reacting chamber connected with fluidics channels. Photoluminescence of a DNA solution in the PCR reactive chamber is carried out through the transparent top layers.
    Type: Grant
    Filed: September 16, 2013
    Date of Patent: January 19, 2016
    Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Samson Chen, Aditya Rajagopal, Axel Scherer
  • Patent number: 8707545
    Abstract: A printed circuit board structure is coated with an encapsulant within which microfluidic channels have been formed. The microfluidic channels are formed by soldering fluidic connections to metal traces on a surface of the printed circuit board structure prior to encapsulation. The metal traces are removed by etching after encapsulation to form microchannels within the encapsulant.
    Type: Grant
    Filed: September 26, 2013
    Date of Patent: April 29, 2014
    Assignee: California Institute of Technology
    Inventors: Samson Chen, Aditya Rajagopal, Axel Scherer
  • Publication number: 20140100102
    Abstract: Methods and devices for molecular analysis are disclosed, based on centrifugation. A centrifuge device comprises strips of centrifuge tubes and elements to create a magnetic field. The magnetic shear forces applied to beads inside a solution with biological molecules permit the performance of different analytic techniques, such as lysis and sample preparation for PCR.
    Type: Application
    Filed: October 8, 2013
    Publication date: April 10, 2014
    Applicant: California Institute Of Technology
    Inventors: Aditya RAJAGOPAL, Emil P. KARTALOV, Carl J. ALLENDORPH, Axel SCHERER, Samson CHEN
  • Publication number: 20140080133
    Abstract: Novel methods and systems for polymerase chain reaction (PCR) are disclosed. A PCR device has a bottom heater layer, a central reacting layer, and a top heater layer. The central reacting layer has a PCR reacting chamber connected with fluidics channels. Photoluminescence of a DNA solution in the PCR reactive chamber is carried out through the transparent top layers.
    Type: Application
    Filed: September 16, 2013
    Publication date: March 20, 2014
    Inventors: Samson CHEN, Aditya RAJAGOPAL, Axel SCHERER
  • Publication number: 20140026413
    Abstract: A printed circuit board structure is coated with an encapsulant within which microfluidic channels have been formed. The microfluidic channels are formed by soldering fluidic connections to metal traces on a surface of the printed circuit board structure prior to encapsulation. The metal traces are removed by etching after encapsulation to form microchannels within the encapsulant.
    Type: Application
    Filed: September 26, 2013
    Publication date: January 30, 2014
    Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Samson CHEN, Aditya RAJAGOPAL, Axel SCHERER
  • Patent number: 8574513
    Abstract: A printed circuit board structure is coated with an encapsulant within which microfluidic channels have been formed. The microfluidic channels are formed by soldering fluidic connections to metal traces on a surface of the printed circuit board structure prior to encapsulation. The metal traces are removed by etching after encapsulation to form microchannels within the encapsulant.
    Type: Grant
    Filed: April 17, 2012
    Date of Patent: November 5, 2013
    Assignee: California Institute of Technology
    Inventors: Samson Chen, Aditya Rajagopal, Axel Scherer
  • Patent number: 8438351
    Abstract: A method and computer-readable memory device that enable processing of a first memory image comprising a plurality of compressed sub-blocks and uncompressed sub-blocks to produce a second memory image comprising contents of the first memory image arranged as a plurality of memory blocks. The memory blocks of the second memory image may be independently decompressible, to enable more efficient updating of an electronic device.
    Type: Grant
    Filed: June 6, 2008
    Date of Patent: May 7, 2013
    Assignee: Hewlett-Packard Development Company, L.P.
    Inventors: Samson Chen, Marko Slyz, LaShawn McGhee, Giovanni Motta, Brian O'Neill, Bill Liu, Li Wen, Ben-Tong Sun