Patents by Inventor Samson Chen

Samson Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Low power, chemically amplified, electrically removable barrier
    Patent number: 11904045
    Abstract: An implantable device contains a drug or biosensing compound, protected from the external environment within a human body by several barriers which are broken upon activation of the device through electrothermal, chemical, and mechanical processes. The device allows accurate and repeated dosing within a human body, thus reducing the number of implantation procedures required. This device extends the lifetime of a biosensor, reducing the number of implantation procedures required.
    Type: Grant
    Filed: May 14, 2021
    Date of Patent: February 20, 2024
    Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Samson Chen, Axel Scherer, Richard Daniel Smith, Jr.
  • Switchable low voltage electrochemical sensing for interfering species rejection
    Patent number: 11903708
    Abstract: A sensor implanted in tissues and including a sensing enzyme takes an electrical measurement and compares it to reference curves for the voltage current relationship. The sensor determines whether molecular compounds are present which interfere with the detection of the molecule of interest. If interfering species are found, the measurement voltage is set in a low range to reduce errors, while if the interfering species are not found, the measurement voltage is set in a high range to increase the detected signal.
    Type: Grant
    Filed: September 27, 2018
    Date of Patent: February 20, 2024
    Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Samson Chen, Axel Scherer, Muhammad Musab Jilani, Xiomara L. Madero
  • METHOD OF PRODUCING THIN ENZYME-BASED SENSING LAYERS ON PLANAR SENSORS
    Publication number: 20230363672
    Abstract: A sensor implanted in tissues and including a sensing layer is fabricated by mixing the signal transduction enzyme with non-reactive components including buffer salts and fillers, and spin coating the enzyme onto a substrate. The signal transduction enzyme is crosslinked by introducing the coated substrate in a vacuum chamber. In the chamber, a crosslinker evaporates and is deposited onto the enzyme, therefore crosslinking the enzyme.
    Type: Application
    Filed: May 17, 2023
    Publication date: November 16, 2023
    Inventors: Samson CHEN, Axel SCHERER, Dvin I. ADALIAN, Peter PETILLO, Muhammad Musab JILANI, Xiomara L. MADERO, Deepan KISHORE KUMAR
  • Method of producing thin enzyme-based sensing layers on planar sensors
    Patent number: 11690544
    Abstract: A sensor implanted in tissues and including a sensing layer is fabricated by mixing the signal transduction enzyme with non-reactive components including buffer salts and fillers, and spin coating the enzyme onto a substrate. The signal transduction enzyme is crosslinked by introducing the coated substrate in a vacuum chamber. In the chamber, a crosslinker evaporates and is deposited onto the enzyme, therefore crosslinking the enzyme.
    Type: Grant
    Filed: May 7, 2021
    Date of Patent: July 4, 2023
    Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Samson Chen, Axel Scherer, Dvin Adalian, Peter Petillo, Muhammad Musab Jilani, Xiomara L. Madero, Deepan Kishore Kumar
  • Wireless automated animal monitoring system
    Patent number: 11666216
    Abstract: A smart cage includes radiofrequency transceivers and tags attached to laboratory animals. The tags include sensors to detect monitorable conditions of the laboratory animals. The sensors include working electrodes, counter electrodes, reference electrodes, and potentiostats. The top surface of the electrodes is coated with ionophores or enzymes which detect the monitorable conditions of the laboratory animals.
    Type: Grant
    Filed: May 23, 2018
    Date of Patent: June 6, 2023
    Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Axel Scherer, Peter A Petillo, Samson Chen, Azita Emami
  • METHODS AND SYSTEMS FOR FABRICATING BIOSENSORS
    Publication number: 20230121718
    Abstract: Methods and systems are described for fabricating thin hydrogel layers on biosensors by a drop-spin method, which includes placing a drop of the hydrogel on the electrode, spinning the wafer at high speed in a vacuum, and heating the wafer to cure. One and multilayer sensors can be fabricated in this way, by adding layers of hydrogel or metal.
    Type: Application
    Filed: October 14, 2022
    Publication date: April 20, 2023
    Inventors: Oliver PLETTENBURG, Christin AHLBRECHT, Dvin ADALIAN, Axel SCHERER, Xiomara Linnette MADERO, Samson CHEN, Muhammad Musab JILANI
  • Low power, chemically amplified, electrically removable barrier
    Patent number: 11304893
    Abstract: An implantable device contains a drug or biosensing compound, protected from the external environment within a human body by several barriers which are broken upon activation of the device through electrothermal, chemical, and mechanical processes. The device allows accurate and repeated dosing within a human body, thus reducing the number of implantation procedures required. This device extends the lifetime of a biosensor, reducing the number of implantation procedures required.
    Type: Grant
    Filed: July 24, 2018
    Date of Patent: April 19, 2022
    Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Samson Chen, Axel Scherer, Richard Daniel Smith, Jr.
  • METAL-ENZYME SANDWICH LAYERS
    Publication number: 20220071529
    Abstract: Measurement of target analytes is carried out with an enzyme-based sensor. The enzyme hydrogel is protected by a porous layer of a metallic material. The size of the pores is small enough to prevent degradation of the enzyme layer caused by the immune system of an organism, but large enough to allow transfer of molecules that participate in the electrochemical reaction allowing the enzyme to detect the target analytes.
    Type: Application
    Filed: August 18, 2021
    Publication date: March 10, 2022
    Inventors: Dvin ADALIAN, Samson CHEN, Muhammad M. JILANI, Axel SCHERER, Xiomara Linnette MADERO, Richard SMITH
  • METHOD OF PRODUCING THIN ENZYME-BASED SENSING LAYERS ON PLANAR SENSORS
    Publication number: 20210321918
    Abstract: A sensor implanted in tissues and including a sensing layer is fabricated by mixing the signal transduction enzyme with non-reactive components including buffer salts and fillers, and spin coating the enzyme onto a substrate. The signal transduction enzyme is crosslinked by introducing the coated substrate in a vacuum chamber. In the chamber, a crosslinker evaporates and is deposited onto the enzyme, therefore crosslinking the enzyme.
    Type: Application
    Filed: May 7, 2021
    Publication date: October 21, 2021
    Inventors: Samson CHEN, Axel SCHERER, Dvin ADALIAN, Peter PETILLO, Muhammad Musab JILANI, Xiomara L. MADERO, Deepan KISHORE KUMAR
  • LOW POWER, CHEMICALLY AMPLIFIED, ELECTRICALLY REMOVABLE BARRIER
    Publication number: 20210322300
    Abstract: An implantable device contains a drug or biosensing compound, protected from the external environment within a human body by several barriers which are broken upon activation of the device through electrothermal, chemical, and mechanical processes. The device allows accurate and repeated dosing within a human body, thus reducing the number of implantation procedures required. This device extends the lifetime of a biosensor, reducing the number of implantation procedures required.
    Type: Application
    Filed: May 14, 2021
    Publication date: October 21, 2021
    Inventors: Samson CHEN, Axel SCHERER, Richard Daniel SMITH, JR.
  • Metal-enzyme sandwich layers
    Patent number: 11109784
    Abstract: Measurement of target analytes is carried out with an enzyme-based sensor. The enzyme hydrogel is protected by a porous layer of a metallic material. The size of the pores is small enough to prevent degradation of the enzyme layer caused by the immune system of an organism, but large enough to allow transfer of molecules that participate in the electrochemical reaction allowing the enzyme to detect the target analytes.
    Type: Grant
    Filed: November 14, 2018
    Date of Patent: September 7, 2021
    Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Dvin Adalian, Samson Chen, Muhammad M. Jilani, Axel Scherer, Xiomara Linnette Madero, Richard Smith
  • Method of producing thin enzyme-based sensing layers on planar sensors
    Patent number: 11026610
    Abstract: A sensor implanted in tissues and including a sensing layer is fabricated by mixing the signal transduction enzyme with non-reactive components including buffer salts and fillers, and spin coating the enzyme onto a substrate. The signal transduction enzyme is crosslinked by introducing the coated substrate in a vacuum chamber. In the chamber, a crosslinker evaporates and is deposited onto the enzyme, therefore crosslinking the enzyme.
    Type: Grant
    Filed: September 27, 2018
    Date of Patent: June 8, 2021
    Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Samson Chen, Axel Scherer, Dvin Adalian, Peter Petillo, Muhammad Musab Jilani, Xiomara L. Madero, Deepan Kishore Kumar
  • In situ chemical sensing electrode reconditioning
    Patent number: 10996185
    Abstract: A cycle of positive and negative voltage pulses applied to an electrode sensor removes passivation of an electrode surface. The conditioned sensors have improved sensitivity to concentrations for analytes of interest. The electrode surfaces can also be passivated on purpose to reduce sensitivity. The voltages applied are varied according to the solution present.
    Type: Grant
    Filed: May 22, 2017
    Date of Patent: May 4, 2021
    Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Samson Chen, Axel Scherer, Muhammad M. Jilani
  • METAL-ENZYME SANDWICH LAYERS
    Publication number: 20190307378
    Abstract: Measurement of target analytes is carried out with an enzyme-based sensor. The enzyme hydrogel is protected by a porous layer of a metallic material. The size of the pores is small enough to prevent degradation of the enzyme layer caused by the immune system of an organism, but large enough to allow transfer of molecules that participate in the electrochemical reaction allowing the enzyme to detect the target analytes.
    Type: Application
    Filed: November 14, 2018
    Publication date: October 10, 2019
    Inventors: Dvin ADALIAN, Samson CHEN, Muhammad M. JILANI, Axel SCHERER, Xiomara Linnette MADERO, Richard SMITH
  • PC board fluidic devices
    Patent number: 10376892
    Abstract: PC board fluidic devices for performing a Polymerase Chain Reaction (PCR) are disclosed. The devices comprise a printed circuit board and a PCR chamber. The PCR chamber is a fluidic chamber and is located in, or is part of, the PC board. The PC board can include a coil trace heating element with a temperature sensor and controller.
    Type: Grant
    Filed: November 23, 2016
    Date of Patent: August 13, 2019
    Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Aditya Rajagopal, Samson Chen, Axel Scherer, Christopher I. Walker
  • SWITCHABLE LOW VOLTAGE ELECTROCHEMICAL SENSING FOR INTERFERING SPECIES REJECTION
    Publication number: 20190090797
    Abstract: A sensor implanted in tissues and including a sensing enzyme takes an electrical measurement and compares it to reference curves for the voltage current relationship. The sensor determines whether molecular compounds are present which interfere with the detection of the molecule of interest. If interfering species are found, the measurement voltage is set in a low range to reduce errors, while if the interfering species are not found, the measurement voltage is set in a high range to increase the detected signal.
    Type: Application
    Filed: September 27, 2018
    Publication date: March 28, 2019
    Inventors: Samson CHEN, Axel SCHERER
  • METHOD OF PRODUCING THIN ENZYME-BASED SENSING LAYERS ON PLANAR SENSORS
    Publication number: 20190090796
    Abstract: A sensor implanted in tissues and including a sensing layer is fabricated by mixing the signal transduction enzyme with non-reactive components including buffer salts and fillers, and spin coating the enzyme onto a substrate. The signal transduction enzyme is crosslinked by introducing the coated substrate in a vacuum chamber. In the chamber, a crosslinker evaporates and is deposited onto the enzyme, therefore crosslinking the enzyme.
    Type: Application
    Filed: September 27, 2018
    Publication date: March 28, 2019
    Inventors: Samson CHEN, Axel SCHERER
  • LOW POWER, CHEMICALLY AMPLIFIED, ELECTRICALLY REMOVABLE BARRIER
    Publication number: 20190060218
    Abstract: An implantable device contains a drug or biosensing compound, protected from the external environment within a human body by several barriers which are broken upon activation of the device through electrothermal, chemical, and mechanical processes. The device allows accurate and repeated dosing within a human body, thus reducing the number of implantation procedures required. This device extends the lifetime of a biosensor, reducing the number of implantation procedures required.
    Type: Application
    Filed: July 24, 2018
    Publication date: February 28, 2019
    Inventors: Samson CHEN, Axel SCHERER, Richard Daniel SMITH, JR.
  • WIRELESS AUTOMATED ANIMAL MONITORING SYSTEM
    Publication number: 20180338681
    Abstract: A smart cage includes radiofrequency transceivers and tags attached to laboratory animals. The tags include sensors to detect monitorable conditions of the laboratory animals. The sensors include working electrodes, counter electrodes, reference electrodes, and potentiostats. The top surface of the electrodes is coated with ionophores or enzymes which detect the monitorable conditions of the laboratory animals.
    Type: Application
    Filed: May 23, 2018
    Publication date: November 29, 2018
    Inventors: Axel SCHERER, Peter A. PETILLO, Samson CHEN, Azita EMAMI
  • IN SITU CHEMICAL SENSING ELECTRODE RECONDITIONING
    Publication number: 20170336340
    Abstract: A cycle of positive and negative voltage pulses applied to an electrode sensor removes passivation of an electrode surface. The conditioned sensors have improved sensitivity to concentrations for analytes of interest. The electrode surfaces can also be passivated on purpose to reduce sensitivity. The voltages applied are varied according to the solution present.
    Type: Application
    Filed: May 22, 2017
    Publication date: November 23, 2017
    Inventors: Samson CHEN, Axel SCHERER, Muhammad M. JILANI