Abstract: Methods and kits for detecting polymorphisms that are predictive of a subject's susceptibility to developing an obstructive airway disease, such as asthma, as well as for determining the relative severity of the disease are described. Assays for identify therapeutics are also described.

Abstract: A screening method for identifying a drug-like compound or lead compound for the development of a drug-like compound in which (1) a xanthine or related compound is exposed to a histone deacetylase, (2) the binding of the compound to the histone deacetylase is measured or the change in the activity of the histone deacetylase is measured or the change in the binding of the histone deacetylase to activated glucocorticoid receptor (GR) is measured and (3) any compound capable of the required binding to the histone deacetylase or producing the required change in the activity of the histone deacetylase or its binding to activated glucocorticoid receptor is identified. Methods of treatment make use of compounds identifiable by the screening methods.

Abstract: The present invention provides a novel method for the early prediction of a propensity to develop chronic obstructive airway disorders such as asthma. The present invention also provides kits for the early determination of the propensity to develop such a disorder. The method consists of detecting the presence of one or more alleles of an IL-1B haplotype, specifically the IL-1b (+3954) and the IL-1B (-511) loci. The presence of allele 2 at the IL-1b (+3954) locus indicates increased risk for a chronic obstructive airway disorder. The presence of allele 2 at the IL-1B (-511) locus indicates susceptibility to more severe expression of chronic obstructive airway disorders.

Abstract: A subscription television system in which individual decoders are enabled to receive individually addressed messages is disclosed. The composite signal, including video and teletext, also comprises addressed packets which are detected by decoders and which indicate that a message addressed to a particular subscriber is forthcoming, and system control data. In a preferred embodiment, both addressed packets and teletext are encrypted. The addressed packet is decrypted using a decoder-specific code and a transmitted code, while the teletext message is decrypted using a decryption key contained in the system control data. The teletext message cannot be received until the addressed packet has been decrypted. Therefore, redundant levels of security are provided to the system. Messages for display to the user can be selected in response to user initiated commands, in response to decoder initiation, or in response to the transmitter.

Abstract: A subscription television system for distributing program material protected by copyright to subscribers comprises a transmitter including a data insertion circuit for inserting a control bit in a transmitted signal comprising other control data and the protected program material. A receiver of the system includes a memory for storing a pre-assigned subscriber identification. Upon receipt and identification of the control bit at the receiver, the receiver inserts the subscriber identification into the program material so that any unauthorized copy made of the program material may be found to include the subscriber identification.

Abstract: A communication system enabling transmission of individual subscriber teletext messages, audio and video to individual subscribers and permitting group communications of audio, video, teletext and data information from a single central subscriber location, such as a corporate head office to a plurality of satellite offices, such as field or sales offices of the corporation, is disclosed. A composite signal including the information to be transmitted as well as system wide, individual decoder and group decoder control signals is transmitted. The system-wide control signals include data germane to operation of each of the decoders of this system, including key information needed to decode the composite signal. The system-wide control data is transmitted at a first relatively high frequency. The group decoder information includes information permitting individual groups of decoders to receive information portion of the composite signal being transmitted at a given time.

Abstract: A subscription television system in which individual decoders are enabled to receive individually addressed messages is disclosed. The composite signal, including video and teletext, also comprises addressed packets, which are detected by decoders and which indicate that a message addressed to a particular subscriber is forthcoming, and system control data. The decoder detects an addressed packet addressed to itself, whereby it is enabled to select the appropriate teletext message and to display the same. In a preferred embodiment, both address packets and teletext are encrypted. The addressed packet is decrypted using a decoder-specific code and a system key transmitted as part of the system control data, while the teletext packet is decrypted using the system key, but cannot be received until the addressed packet has been decrypted. Therefore, redundant levels of security are provided to the system.