Patents by Inventor Samuël Dominique Demin

Samuël Dominique Demin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MACROCYCLIC 7-PYRAZOL-5-YL-INDOLE DERIVATIVES AS INHIBITORS OF MCL-1
    Publication number: 20230265105
    Abstract: The present invention relates to pharmaceutical agents useful for therapy and/or prophylaxis in a subject, pharmaceutical composition comprising such compounds, and their use as MCL-1 inhibitors, useful for treating diseases such as cancer.
    Type: Application
    Filed: May 27, 2021
    Publication date: August 24, 2023
    Inventors: Frederik Jan Rita ROMBOUTS, Aldo PESCHIULLI, Samuël Dominique DEMIN, Adriana-Ingrid VELTER, Matthieu Dominique JOUFFROY
  • SUBSTITUTED PHENYL-1H-PYRROLO[2,3-c] PYRIDINE DERIVATIVES
    Publication number: 20230250096
    Abstract: The present invention relates to pharmaceutical agents useful for therapy and/or prophylaxis in a mammal, pharmaceutical composition comprising such compounds, and their use as menin/MLL protein/protein interaction inhibitors, useful for treating diseases such as cancer, including but not limited to leukemia, myelodysplastic syndrome (MDS), and myeloproliferative neoplasms (MPN); and diabetes.
    Type: Application
    Filed: May 30, 2022
    Publication date: August 10, 2023
    Inventors: Wei Cai, Johannes Wilhelmus J. Thuring, Fabian Hulpia, Xuedong Dai, Ming Li, Xiangjun Deng, Chao Liang, Alicia Tee Fuay Ng, Zhen Sun, Zhigao Zhang, Samuel Dominique Demin, Natalia Nikolaevna Dyubankova, Matthiew Dominique Jouffroy, Susan Lepri, Nicolas Freddy J. Darville, Vineet Pande, Wim Bert Griet Schepens, James Patrick Edwards, Olivier Alexis Georges Querolle
  • CYCLIZED SULFAMOYLARYLAMIDE DERIVATIVES AND THE USE THEREOF AS MEDICAMENTS FOR THE TREATMENT OF HEPATITIS B
    Publication number: 20210179635
    Abstract: Inhibitors of HBV replication of Formula (I-A) including stereochemically isomeric forms, and salts, hydrates, solvates thereof, wherein Ra to Rd, and R1 to R8 have the meaning as defined herein. The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other HBV inhibitors, in HBV therapy.
    Type: Application
    Filed: December 18, 2020
    Publication date: June 17, 2021
    Inventors: Sandrine Marie Helene VENDEVILLE, Stefaan Julien LAST, Samuël Dominique DEMIN, Sandrine Céline GROSSE, Geerwin Yvonne Paul HACHÉ, Lili HU, Serge Maria Aloysius PIETERS, Geert ROMBOUTS, Koen VANDYCK, Wim Gaston VERSCHUEREN, Pierre Jean-Marie Bernard RABOISSON
  • Cyclized sulfamoylarylamide derivatives and the use thereof as medicaments for the treatment of hepatitis B
    Patent number: 10875876
    Abstract: Inhibitors of HBV replication of Formula (I-A) including stereochemically isomeric forms, and salts, hydrates, solvates thereof, wherein Ra to Rd, and R1 to R8 have the meaning as defined herein. The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other HBV inhibitors, in HBV therapy.
    Type: Grant
    Filed: June 28, 2016
    Date of Patent: December 29, 2020
    Assignee: JANSSEN SCIENCES IRELAND UC
    Inventors: Sandrine Marie Helene Vendeville, Stefaan Julien Last, Samuël Dominique Demin, Sandrine Céline Grosse, Geerwin Yvonne Paul Haché, Lili Hu, Serge Maria Aloysius Pieters, Geert Rombouts, Koen Vandyck, Wim Gaston Verschueren, Pierre Jean-Marie Bernard Raboisson
  • Quinoxalinones and dihydroquinoxalinones as respiratory syncytial virus antiviral agents
    Patent number: 10501445
    Abstract: Quinoxalinones and dihydroquinoxalinones having inhibitory activity on RSV replication and having the formula I including addition salts, and stereochemically isomeric forms thereof; compositions containing these compounds as active ingredient and processes for preparing these compounds and compositions.
    Type: Grant
    Filed: September 24, 2018
    Date of Patent: December 10, 2019
    Assignee: Janssen Sciences Ireland UC
    Inventors: Abdellah Tahri, Tim Hugo Maria Jonckers, Pierre Jean-Marie Bernard Raboisson, Samuel Dominique Demin
  • QUINOXALINONES AND DIHYDROQUINOXALINONES AS RESPIRATORY SYNCYTIAL VIRUS ANTIVIRAL AGENTS
    Publication number: 20190023692
    Abstract: Quinoxalinones and dihydroquinoxalinones having inhibitory activity on RSV replication and having the formula I including addition salts, and stereochemically isomeric forms thereof; compositions containing these compounds as active ingredient and processes for preparing these compounds and compositions.
    Type: Application
    Filed: September 24, 2018
    Publication date: January 24, 2019
    Inventors: Abdellah TAHRI, Tim Hugo Maria JONCKERS, Pierre Jean-Marie Bernard RABOISSON, Samuël Dominique DEMIN
  • Piperidine substituted tricyclic pyrazolo[1,5-a]pyrimidine derivatives with inhibitory activity on the replication of the respiratory syncytial virus (RSV)
    Patent number: 10131673
    Abstract: The invention concerns novel substituted tricyclic pyrazolo pyrimidine compounds of formula (I-a) or (I-b) having antiviral activity, in particular, having an inhibitory activity on the replication of the respiratory syncytial virus (RSV). The invention further concerns the preparation of such novel compounds, compositions comprising these compounds, and the compounds for use in the treatment of respiratory syncytial virus infection.
    Type: Grant
    Filed: December 7, 2015
    Date of Patent: November 20, 2018
    Assignee: Janssen Sciences Ireland UC
    Inventors: Abdellah Tahari, Sandrine Marie Helene Vendeville, Tim Hugo Maria Jonckers, Pierre Jean-Marie Bernard Raboisson, Samuël Dominique Demin, Lili Hu
  • Quinoxalinones and dihydroquinoxalinones as respiratory syncytial virus ativiral agents
    Patent number: 10081618
    Abstract: Quinoxalinones and dihydroquinoxalinones having inhibitory activity on RSV replication and having the formula I including addition salts, and stereochemically isomeric forms thereof; compositions containing these compounds as active ingredient and processes for preparing these compounds and compositions.
    Type: Grant
    Filed: January 27, 2014
    Date of Patent: September 25, 2018
    Assignee: Janssen Sciences Ireland UC
    Inventors: Abdellah Tahri, Tim Hugo Maria Jonckers, Pierre Jean-Marie-Bernard Raboisson, Samuël Dominique Demin
  • Piperidine substituted pyrazolo[1,5-A]pyrimidine derivatives with inhibitory activity on the replication of the respiratory syncytial virus (RSV)
    Patent number: 9981976
    Abstract: The invention concerns novel substituted bicyclic pyrazolo pyrimidine compounds of formula (I) having antiviral activity, in particular, having an inhibitory activity on the replication of the respiratory syncytial virus (RSV). The invention further concerns the preparation of such novel compounds, compositions comprising these compounds, and the compounds for use in the treatment of respiratory syncytial virus infection.
    Type: Grant
    Filed: December 7, 2015
    Date of Patent: May 29, 2018
    Assignee: Janssen Sciences Ireland UC
    Inventors: Abdellah Tahari, Sandrine Marie Helene Vendeville, Tim Hugo Maria Jonckers, Pierre Jean-Marie Bernard Raboisson, Samuël Dominique Demin, Lili Hu, Ludwig Paul Cooymans
  • Indoles as respiratory syncytial virus antiviral agents
    Patent number: 9944638
    Abstract: Indoles having inhibitory activity on RSV replication and having the formula I the prodrugs, N-oxides, addition salts, quaternary amines, metal complexes and stereochemically isomeric forms thereof; compositions containing these compounds as active ingredient and processes for preparing these compounds and compositions.
    Type: Grant
    Filed: April 22, 2016
    Date of Patent: April 17, 2018
    Assignee: JANSSEN SCIENCES IRELAND US
    Inventors: Ludwig Paul Cooymans, Samuël Dominique Demin, Lili Hu, Tim Hugo Maria Jonckers, Pierre Jean-Marie Bernard Raboisson, Abdellah Tahri, Sandrine Marie Helene Vendeville
  • Azaindoles as respiratory syncytial virus antiviral agents
    Patent number: 9896459
    Abstract: Azaindoles having inhibitory activity on RSV replication and having the formula I compositions containing these compounds as active ingredient and processes for preparing these compounds and compositions.
    Type: Grant
    Filed: May 12, 2016
    Date of Patent: February 20, 2018
    Assignee: Janssen Sciences Ireland UC
    Inventors: Ludwig Paul Cooymans, Samuël Dominique Demin, Lili Hu, Tim Hugo Maria Jonckers, Pierre Jean-Marie Bernard Raboisson, Abdellah Tahri, Sandrine Marie Helene Vendeville
  • Azabenzimidazoles as respiratory syncytial virus antiviral agents
    Patent number: 9890178
    Abstract: A compound satisfying formula I, a prodrug, N-oxide, addition salt, quaternary amine, metal complex, or a stereochemically isomeric form thereof; compositions contain these compounds as active ingredient and processes for preparing these compounds and compositions.
    Type: Grant
    Filed: April 22, 2016
    Date of Patent: February 13, 2018
    Assignee: Janssen Sciences Ireland UC
    Inventors: Ludwig Paul Cooymans, Samuël Dominique Demin, Lili Hu, Tim Hugo Maria Jonckers, Pierre Jean-Marie Bernard Raboisson, Abdellah Tahri, Sandrine Marie Helene Vendeville
  • 1,3-dihydro-2H-benzimidazol-2-one derivatives substituted with heterocycles as respiratory syncytial virus antiviral agents
    Patent number: 9845321
    Abstract: The present invention is concerned with novel 1,3-dihydro-2H-benzimidazol-2-one derivatives substituted with heterocycles having formula (I) stereoisomeric forms thereof, and the pharmaceutically acceptable addition salts, and the solvates thereof, wherein R4, R5, Z and Het have the meaning defined in the claims. The compounds according to the present invention are useful as inhibitors on the replication of the respiratory syncytial virus (RSV). The invention further concerns the preparation of such novel compounds, compositions comprising these compounds, and the compounds for use in the treatment of respiratory syncytial virus infection.
    Type: Grant
    Filed: January 8, 2016
    Date of Patent: December 19, 2017
    Assignee: Janssen Sciences Ireland UC
    Inventors: Abdellah Tahri, Tim Hugo Maria Jonckers, Pierre Jean-Marie Bernard Raboisson, Sandrine Marie Helene Vendeville, Lili Hu, Samuel Dominique Demin, Ludwig Paul Cooymans
  • PIPERIDINE SUBSTITUTED PYRAZOLO[1,5-A]PYRIMIDINE DERIVATIVES WITH INHIBITORY ACTIVITY ON THE REPLICATION OF THE RESPIRATORY SYNCYTIAL VIRUS (RSV)
    Publication number: 20170349591
    Abstract: The invention concerns novel substituted bicyclic pyrazolo pyrimidine compounds of formula (I) having antiviral activity, in particular, having an inhibitory activity on the replication of the respiratory syncytial virus (RSV). The invention further concerns the preparation of such novel compounds, compositions comprising these compounds, and the compounds for use in the treatment of respiratory syncytial virus infection.
    Type: Application
    Filed: December 7, 2015
    Publication date: December 7, 2017
    Inventors: Abdellah TAHARI, Sandrine Marie Helene VENDEVILLE, Tim Hugo Maria JONCKERS, Pierre Jean-Marie Bernard RABOISSON, Samuël Dominique DEMIN, Lili HU, Ludwig Paul COOYMANS
  • PIPERIDINE SUBSTITUTED TRICYCLIC PYRAZOLO[1,5-A]PYRIMIDINE DERIVATIVES WITH INHIBITORY ACTIVITY ON THE REPLICATION OF THE RESPIRATORY SYNCYTIAL VIRUS (RSV)
    Publication number: 20170349602
    Abstract: The invention concerns novel substituted tricyclic pyrazolo pyrimidine compounds of formula (I-a) or (I-b) having antiviral activity, in particular, having an inhibitory activity on the replication of the respiratory syncytial virus (RSV). The invention further concerns the preparation of such novel compounds, compositions comprising these compounds, and the compounds for use Sin the treatment of respiratory syncytial virus infection.
    Type: Application
    Filed: December 7, 2015
    Publication date: December 7, 2017
    Inventors: Abdellah TAHARI, Sandrine Marie Helene VENDEVILLE, Tim Hugo Maria JONCKERS, Pierre Jean-Marie Bernard RABOISSON, Samuël Dominique DEMIN, Lili HU
  • QUINOXALINONES AND DIHYDROQUINOXALINONES AS RESPIRATORY SYNCYTIAL VIRUS ATIVIRAL AGENTS
    Publication number: 20170260166
    Abstract: Quinoxalinones and dihydroquinoxalinones having inhibitory activity on RSV replication and having the formula I including addition salts, and stereochemically isomeric forms thereof; compositions containing these compounds as active ingredient and processes for preparing these compounds and compositions.
    Type: Application
    Filed: January 27, 2014
    Publication date: September 14, 2017
    Inventors: Abdellah Tahri, Tim Hugo Maria Jonckers, Pierre Jean-Marie-Bernard Raboisson, Samuël Dominique Demin
  • Spiro urea compounds as RSV antiviral compounds
    Patent number: 9738652
    Abstract: The invention concerns novel substituted spiro urea azetidinyl or piperidinyl compounds of formula (I) having antiviral activity, in particular, having an inhibitory activity on the replication of the respiratory syncytial virus (RSV). The invention further concerns the preparation of such novel compounds, compositions comprising these compounds, and the compounds for use in the treatment of respiratory syncytial virus infection.
    Type: Grant
    Filed: April 13, 2015
    Date of Patent: August 22, 2017
    Assignee: JANSSEN SCIENCES IRELAND UC
    Inventors: Lili Hu, Samuël Dominique Demin, Sandrine Marie Helene Vendeville, Abdellah Tahri, Pierre Jean-Marie Bernard Raboisson
  • RSV antiviral compounds
    Patent number: 9617289
    Abstract: Inhibitors of RSV replication of formula RI including stereochemically isomeric forms, and salts or solvates thereof, wherein R22, W, Q, V, Z p, s, and Het have the meaning as defined herein. The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other RSV inhibitors, in RSV therapy.
    Type: Grant
    Filed: October 15, 2013
    Date of Patent: April 11, 2017
    Assignee: JANSSEN SCIENCES IRELAND UC
    Inventors: Abdellah Tahri, Sandrine Marie Helene Vendeville, Tim Hugo Maria Jonckers, Pierre Jean-Marie Bernard Raboisson, Lili Hu, Samuël Dominique Demin, Ludwig Paul Cooymans
  • SPIRO UREA COMPOUNDS AS RSV ANTIVIRAL COMPOUNDS
    Publication number: 20170044172
    Abstract: The invention concerns novel substituted spiro urea azetidinyl or piperidinyl compounds of formula (I) having antiviral activity, in particular, having an inhibitory activity on the replication of the respiratory syncytial virus (RSV). The invention further concerns the preparation of such novel compounds, compositions comprising these compounds, and the compounds for use in the treatment of respiratory syncytial virus infection.
    Type: Application
    Filed: April 13, 2015
    Publication date: February 16, 2017
    Inventors: Lili HU, Samuël Dominique DEMIN, Sandrine Marie Helene VENDEVILLE, Abdellah TAHRI, Pierre Jean-Marie Bernard RABOISSON
  • CYCLIZED SULFAMOYLARYLAMIDE DERIVATIVES AND THE USE THEREOF AS MEDICAMENTS FOR THE TREATMENT OF HEPATITIS B
    Publication number: 20170002025
    Abstract: Inhibitors of HBV replication of Formula (I-A) including stereochemically isomeric forms, and salts, hydrates, solvates thereof, wherein Ra to Rd, and R1 to R8 have the meaning as defined herein. The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other HBV inhibitors, in HBV therapy.
    Type: Application
    Filed: June 28, 2016
    Publication date: January 5, 2017
    Inventors: Sandrine Marie Helene VENDEVILLE, Stefaan Julien LAST, Samuël Dominique DEMIN, Sandrine Céline GROSSE, Geerwin Yvonne Paul HACHÉ, Lili HU, Serge Maria Aloysius PIETERS, Geert ROMBOUTS, Koen VANDYCK, Wim Gaston VERSCHUEREN, Pierre Jean-Marie Bernard RABOISSON