Patents by Inventor Samuel A. Hasson

Samuel A. Hasson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TREM2 AGONIST BIOMARKERS AND METHODS OF USE THEREOF
    Publication number: 20240102094
    Abstract: The present invention provides a method of treating a disease or conditions associated with a dysfunction of TREM2 in a human patient, such as Alzheimer's disease, comprising administering to the patient a TREM2 agonist. In another aspect, the invention provides a method of assaying a biological sample taken from a patient having Alzheimer's for biomarkers to determine potential benefit or if the disease has an increased probability of responding to treatment with a TREM2 agonist.
    Type: Application
    Filed: December 3, 2021
    Publication date: March 28, 2024
    Applicant: AMGEN INC.
    Inventors: Daniel C. ELLWANGER, Ian N. FOLTZ, Samuel A. HASSON
  • Modulators of mitochondrial protein import
    Patent number: 10758513
    Abstract: The present invention provides compounds that modulate protein translocation in mitochondria, compositions thereof, and methods of identifying, making and using these.
    Type: Grant
    Filed: November 16, 2017
    Date of Patent: September 1, 2020
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Carla M. Koehler, Samuel A. Hasson, Kiyoko Miyata, Michael A. Teitell, Deepa Dabir
  • COINCIDENCE REPORTER GENE SYSTEM
    Publication number: 20180265934
    Abstract: Disclosed is a nucleic acid comprising a nucleotide sequence encoding (i) two or more reporters comprising a first reporter and a second reporter that is different from the first reporter; and (ii) one or more ribosomal skip sequences, wherein a ribosomal skip sequence is positioned between the first and second reporters, wherein the first and second reporters are stoichiometrically co-expressed from the nucleotide sequence and the nucleic acid does not comprise a cytomegalovirus-immediate early (CMV-IE) promoter. Also disclosed are methods of screening test compounds for ability to modulate a biological activity of interest using the nucleic acid, as well as related recombinant expression vectors, host cells, and populations of cells.
    Type: Application
    Filed: March 9, 2018
    Publication date: September 20, 2018
    Applicant: The United States of America, as represented by the Secretary, Department of Health anh Human Serv
    Inventors: James Inglese, Ken Chih-Chien Cheng, Samuel Hasson
  • MODULATORS OF MITOCHONDRIAL PROTEIN IMPORT
    Publication number: 20180221330
    Abstract: The present invention provides compounds that modulate protein translocation in mitochondria, compositions thereof, and methods of identifying, making and using these.
    Type: Application
    Filed: November 16, 2017
    Publication date: August 9, 2018
    Inventors: Carla M. Koehler, Samuel A. Hasson, Kiyoko Miyata, Michael A. Teitell, Deepa Dabir
  • COINCIDENCE REPORTER GENE SYSTEM
    Publication number: 20160024600
    Abstract: Disclosed is a nucleic acid comprising a nucleotide sequence encoding (i) two or more reporters comprising a first reporter and a second reporter that is different from the first reporter; and (ii) one or more ribosomal skip sequences, wherein a ribosomal skip sequence is positioned between the first and second reporters, wherein the first and second reporters are stoichiometrically co-expressed from the nucleotide sequence and the nucleic acid does not comprise a cytomegalovirus-immediate early (CMV-IE) promoter. Also disclosed are methods of screening test compounds for ability to modulate a biological activity of interest using the nucleic acid, as well as related recombinant expression vectors, host cells, and populations of cells.
    Type: Application
    Filed: March 15, 2013
    Publication date: January 28, 2016
    Inventors: James Inglese, Ken Chih-Chien Cheng, Samuel Hasson
  • MODULATORS OF MITOCHONDRIAL PROTEIN IMPORT
    Publication number: 20140249193
    Abstract: The present invention provides compounds that modulate protein translocation in mitochondria, compositions thereof, and methods of identifying, making and using these.
    Type: Application
    Filed: April 12, 2012
    Publication date: September 4, 2014
    Applicant: The Regents of the University of California
    Inventors: Carla M. Koehler, Samuel A. Hasson, Kiyoko Miyata, Micheal A. Teitell, Deepa Dabir