Patents by Inventor Samuel Bader

Samuel Bader has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method to obtain unbiased identification of interaction of test compounds with the proteome
    Patent number: 11024492
    Abstract: The invention provides an unbiased method to assess the binding of a test compound to a multiplicity of proteins in the same sample, including samples from living cells by applying the unbiased determination technique of SWATH-MS or the biased technique of SRM-MS to a thermal shift assay to evaluate drug target interactions. In addition, the results created by SWATH-MS can be analyzed by SRM-MS in a biased manner to assess the binding of a test compound to a multiplicity of proteins in the same sample, including samples from living cells.
    Type: Grant
    Filed: July 5, 2016
    Date of Patent: June 1, 2021
    Assignee: Institute for Systems Biology
    Inventors: Robert L. Moritz, Samuel Bader, Ulrike Kusebauch
  • Method to obtain unbiased identification of interaction of test compounds with the proteome
    Patent number: 10978281
    Abstract: The invention provides an unbiased method to assess the binding of a test compound to a multiplicity of proteins in the same sample, including samples from living cells by applying the unbiased determination technique of SWATH-MS or the biased technique of SRM-MS to a thermal shift assay to evaluate drug target interactions. In addition, the results created by SWATH-MS can be analyzed by SRM-MS in a biased manner to assess the binding of a test compound to a multiplicity of proteins in the same sample, including samples from living cells.
    Type: Grant
    Filed: February 21, 2020
    Date of Patent: April 13, 2021
    Assignee: Institute for Systems Biology
    Inventors: Robert L. Moritz, Samuel Bader, Ulrike Kusebauch
  • METHOD TO OBTAIN UNBIASED IDENTIFICATION OF INTERACTION OF TEST COMPOUNDS WITH THE PROTEOME
    Publication number: 20200251319
    Abstract: The invention provides an unbiased method to assess the binding of a test compound to a multiplicity of proteins in the same sample, including samples from living cells by applying the unbiased determination technique of SWATH-MS or the biased technique of SRM-MS to a thermal shift assay to evaluate drug target interactions. In addition, the results created by SWATH-MS can be analyzed by SRM-MS in a biased manner to assess the binding of a test compound to a multiplicity of proteins in the same sample, including samples from living cells.
    Type: Application
    Filed: February 21, 2020
    Publication date: August 6, 2020
    Applicant: Institute for Systems Biology
    Inventors: Robert L. MORITZ, Samuel BADER, Ulrike KUSEBAUCH
  • METHOD TO OBTAIN UNBIASED IDENTIFICATION OF INTERACTION OF TEST COMPOUNDS WITH THE PROTEOME
    Publication number: 20170010229
    Abstract: The invention provides an unbiased method to assess the binding of a test compound to a multiplicity of proteins in the same sample, including samples from living cells by applying the unbiased determination technique of SWATH-MS or the biased technique of SRM-MS to a thermal shift assay to evaluate drug target interactions. In addition, the results created by SWATH-MS can be analyzed by SRM-MS in a biased manner to assess the binding of a test compound to a multiplicity of proteins in the same sample, including samples from living cells.
    Type: Application
    Filed: July 5, 2016
    Publication date: January 12, 2017
    Applicant: Institute for Systems Biology
    Inventors: Robert L. MORITZ, Samuel BADER, Ulrike KUSEBAUCH
  • Nanosized biological container and manufacture thereof
    Publication number: 20060240456
    Abstract: Nanosized biological containers that are “ghosts” of viruses for which capsids are independent of their endogenous viral nucleic acid cores, provide nano-particles of uniform size, and known numbers of sites for attachments of ligands. These containers can be filled with a fluorescent, magnetic, x-ray absorbent, nucleotide components or a radioactive particle and used as nanoscale markers.
    Type: Application
    Filed: March 20, 2006
    Publication date: October 26, 2006
    Inventors: Liaohai Chen, Samuel Bader, Axel Hoffmann, Brian Kay, Lee Makowski