Patents by Inventor Samuel C. Brooks

Samuel C. Brooks has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions inhibiting estrogen sulfotransferase activity
    Patent number: 4810700
    Abstract: An estrogen sulfotransferase inhibitor composition comprises a compound of the formula ##STR1## wherein R.sub.1 is F, Br, NO.sub.2, or H; R.sub.2 is F, Br, NO.sub.2, NH.sub.2, or H; R is H or alkyl of 1-4 carbon atoms; R.sub.3 is O or H.sub.2 ; and R.sub.4 is H.sub.2, O, or .alpha.-H, .beta.-OH; R.sub.5 is H.sub.2, .alpha.-H and .beta.-OH or B-H and .alpha.-OH in admixture with a pharmaceutically acceptable carrier with the proviso that R.sub.1, R.sub.2 and R.sub.3 cannot all be hydrogen and one of R.sub.1 and R.sub.2 is F.
    Type: Grant
    Filed: May 18, 1983
    Date of Patent: March 7, 1989
    Assignee: Wayne State University
    Inventor: Samuel C. Brooks
  • Compositions inhibiting murine MXT ductal carcinoma
    Patent number: 4668668
    Abstract: A compound of the formula ##STR1## wherein Z is alkoxy of 1-4 carbon atoms and Y is amino, inhibits the growth of murine ductal carcinoma (MXT mammary tumors). A compound wherein Z is OH and Y is nitro, administered orally, inhibits the growth of MXT mammary tumors.
    Type: Grant
    Filed: February 3, 1986
    Date of Patent: May 26, 1987
    Assignee: Wayne State University
    Inventors: Samuel C. Brooks, Jerome P. Horwitz
  • Compositions inhibiting murine MXT ductal carcinoma
    Patent number: 4636496
    Abstract: A compound of the formula ##STR1## wherein Z is hydrogen and Y is nitro, inhibits the growth of murine ductal carcinoma (MXT mammary tumors).
    Type: Grant
    Filed: January 28, 1986
    Date of Patent: January 13, 1987
    Assignee: Wayne State University
    Inventors: Samuel C. Brooks, Jerome P. Horwitz
  • Compositions inhibiting murine MXT ductal carcinoma
    Patent number: 4568673
    Abstract: A compound of the formula ##STR1## wherein Z is alkoxy of 1-4 carbon atoms or hydroxyalkoxy of 2-4 carbon atoms and Y is nitro, inhibiting the growth of murine ductal carcinoma (MXT mammary tumors).
    Type: Grant
    Filed: March 20, 1984
    Date of Patent: February 4, 1986
    Assignee: Wayne State University
    Inventors: Samuel C. Brooks, Jerome P. Horwitz
  • Compounds and compositions for inhibiting estrogen sulfotransferase transferase activity, process and novel intermediates therein
    Patent number: 4496555
    Abstract: The present invention concerns the novel compounds having fluoro, amino, nitro or hydroxy monosubstituted at the 2- or 4- position on deoxyestrone as well as deoxyestra-17-ol. The compounds are useful as estrogen sulfotransferase inhibitors. Such estrogen sulfotransferase inhibition provides the novel use for treating a female mammal to prevent implantation of a blastocyst. Additionally, the invention concerns the novel synthesis and novel intermediates in the synthesis of the estrogen sulfotransferase inhibiting compound of the present invention.
    Type: Grant
    Filed: July 19, 1983
    Date of Patent: January 29, 1985
    Assignee: Wayne State University
    Inventors: Samuel C. Brooks, Jerome P. Horwitz
  • Compositions inhibiting estrogen sulfotransferase activity
    Patent number: 4340602
    Abstract: An estrogen sulfotransferase inhibitor composition comprises a compound of the formula ##STR1## wherein R.sub.1 is Br, NO.sub.2, or H; R.sub.2 is Br, NO.sub.2, NH.sub.2, or H; R is H or alkyl of 1-4 carbon atoms; R.sub.3 is O or H.sub.2 ; and R.sub.4 is H.sub.2, O, or .alpha.-H, .beta.-OH, in admixture with a pharmaceutically acceptable carrier. The specificity of the invention is believed targeted to the substituent at R.sub.2 or C.sub.4 and secondarily the OR group at C.sub.3.
    Type: Grant
    Filed: October 18, 1978
    Date of Patent: July 20, 1982
    Assignee: Wayne State University
    Inventor: Samuel C. Brooks