Patents by Inventor Samuel C. Dudley, Jr.

Samuel C. Dudley, Jr. has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Diagnostics for pulmonary arterial hypertension and sudden cardiac death
    Patent number: 10941447
    Abstract: This invention relates to a diagnostic test measuring circulating SCN5A proteins or gene transcripts in a test sample as a biomarker for pulmonary hypertension.
    Type: Grant
    Filed: February 27, 2017
    Date of Patent: March 9, 2021
    Assignee: Rhode Island Hospital
    Inventors: Samuel C. Dudley, Jr., Corey E. Ventetuolo
  • DIAGNOSTICS FOR PULMONARY ARTERIAL HYPERTENSION AND SUDDEN CARDIAC DEATH
    Publication number: 20180094317
    Abstract: This invention relates to a diagnostic test measuring circulating SCN5A proteins or gene transcripts in a test sample as a biomarker for pulmonary hypertension.
    Type: Application
    Filed: February 27, 2017
    Publication date: April 5, 2018
    Inventors: Samuel C. Dudley, JR., Corey E. Ventetuolo
  • Method for ameliorating or preventing arrhythmic risk associated with cardiomyopathy
    Patent number: 9220720
    Abstract: A method for reducing arrhythmic risk associated with cardiomyopathy includes administering a composition containing NAD+ or a mitochondrial targeted antioxidant to an individual in need thereof.
    Type: Grant
    Filed: July 18, 2012
    Date of Patent: December 29, 2015
    Assignees: U.S. DEPARTMENT OF VETERANS AFFAIRS, THE BOARD OF TRUSTEES OF THE UNIV. OF ILLINOIS
    Inventor: Samuel C. Dudley, Jr.
  • Method for ameliorating or preventing arrhythmic risk associated with cardiomyopathy by improving conduction velocity
    Patent number: 9211301
    Abstract: A method for reducing arrhythmic risk associated with cardiomyopathy by improving conduction velocity, includes administering a composition containing NAD+ or a mitochondrial targeted antioxidant to an individual or person in need thereof.
    Type: Grant
    Filed: August 14, 2012
    Date of Patent: December 15, 2015
    Assignees: U.S. DEPARTMENT OF VETERANS AFFAIRS, THE BOARD OF TRUSTEES OF THE UNIV. OF ILLINOIS
    Inventor: Samuel C. Dudley, Jr.
  • Method for modulating or controlling sodium channel current by reactive oxygen species (ROS) originating from mitochondria
    Patent number: 9114151
    Abstract: Method for modulating or controlling sodium channel current of a cell includes inducing mitochondrial reactive oxygen species (ROS) production in the cell.
    Type: Grant
    Filed: February 16, 2011
    Date of Patent: August 25, 2015
    Assignees: THE UNITED STATES OF AMERICA DEPT. OF VETERANS AFFAIRS, THE BOARD OF TRUSTEES OF THE UNIV. OF ILLINOIS
    Inventor: Samuel C. Dudley, Jr.
  • Method of improving diastolic dysfunction
    Patent number: 9114133
    Abstract: A method of treating, preventing, reversing, or ameliorating diastolic dysfunction includes reducing S-glutathionylated myosin binding protein-C (MyBP-C) level by administering to a host in need thereof a therapeutically effective amount of tetrahydrobiopterin (BH4).
    Type: Grant
    Filed: October 24, 2012
    Date of Patent: August 25, 2015
    Assignees: U.S. DEPT. OF VETERANS AFFAIRS, THE BOARD OF TRUSTEES OF THE UNIV. OF ILLINOIS
    Inventor: Samuel C. Dudley, Jr.
  • Method for modulating or controlling connexin 43(Cx43) level of a cell and reducing arrhythmic risk
    Patent number: 9050350
    Abstract: A method of modulating or controlling connexin 43 (Cx43) level of a cell includes inducing mitochondrial reactive oxygen species (ROS) production in the cell.
    Type: Grant
    Filed: June 21, 2012
    Date of Patent: June 9, 2015
    Assignees: U.S. DEPARTMENT OF VETERANS AFFAIRS, THE BOARD OF TRUSTEES OF THE UNIV. OF ILLINOIS
    Inventor: Samuel C. Dudley, Jr.
  • Method of Treating Diabetes, Glucose Intolerance, Insulin Resistance and/or Diabetes-Induced Diastolic Dysfunction
    Publication number: 20140080789
    Abstract: A method of treating, reversing, or ameliorating type 2 diabetes (DM) includes administering to a host in need thereof a therapeutically effective amount of a mitochondria-targeted antioxidant, such as mito-TEMPO (2-(2,2,6,6-Tetramethylpiperidin-1-oxyl-4-ylamino)-2-oxoethyl)triphenylphosphonium chloride).
    Type: Application
    Filed: November 19, 2013
    Publication date: March 20, 2014
    Applicants: The Board of Trustees of the University of Illinois, U.S. Department of Veterans Affairs
    Inventor: Samuel C. DUDLEY, JR.
  • Method of Improving Diastolic Dysfunction
    Publication number: 20130065903
    Abstract: A method of treating, preventing, reversing, or ameliorating diastolic dysfunction includes reducing S-glutathionylated myosin binding protein-C (MyBP-C) level by administering to a host in need thereof a therapeutically effective amount of tetrahydrobiopterin (BH4).
    Type: Application
    Filed: October 24, 2012
    Publication date: March 14, 2013
    Inventor: Samuel C. DUDLEY, JR.
  • Method for Ameliorating or Preventing Arrhythmic Risk Associated with Cardiomyopathy by Improving Conduction Velocity
    Publication number: 20120308542
    Abstract: A method for reducing arrhythmic risk associated with cardiomyopathy by improving conduction velocity, includes administering a composition containing NAD+ or a mitochondrial targeted antioxidant to an individual or person in need thereof.
    Type: Application
    Filed: August 14, 2012
    Publication date: December 6, 2012
    Applicants: THE BOARD FO TRUSTEES OF THE UNIVERSITY OF ILLINOIS, U.S. DEPARTMENT OF VETERANS AFFAIRS
    Inventor: Samuel C. Dudley, JR.
  • Method for modulating or controlling connexin 43(Cx43) level of a cell and reducing arrhythmic risk
    Publication number: 20120289482
    Abstract: A method of modulating or controlling connexin 43 (Cx43) level of a cell includes inducing mitochondrial reactive oxygen species (ROS) production in the cell.
    Type: Application
    Filed: June 21, 2012
    Publication date: November 15, 2012
    Applicants: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS, U.S. DEPARTMENT OF VETERANS AFFAIRS
    Inventor: Samuel C. Dudley, JR.
  • Method for Ameliorating or Preventing Arrhythmic Risk Associated with Cardiomyopathy
    Publication number: 20120288486
    Abstract: A method for reducing arrhythmic risk associated with cardiomyopathy includes administering a composition containing NAD+ or a mitochondrial targeted antioxidant to an individual in need thereof.
    Type: Application
    Filed: July 18, 2012
    Publication date: November 15, 2012
    Applicants: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS, U.S. DEPARTMENT OF VETERANS AFFAIRS
    Inventor: Samuel C. DUDLEY, JR.
  • Modulation of sodium channels by nicotinamide adenine dinucleotide
    Publication number: 20110288044
    Abstract: The present invention relates to the use of oxidized nicotinamide adenine dinucleotide (NAD+) or of its reduced form, NADH, as sodium channel modulators. The present invention also relates to the use of compositions containing NAD+ or NADH to treat conditions associated with sodium channel current, such as arrhythmia. NAD+ is found to increase sodium channel current, while NADH is found to decrease sodium channel current. Thus, conditions that are associated with decreased sodium channel current can be treated with NAD+, while conditions that is associated with increased sodium channel current can be treated with NADH.
    Type: Application
    Filed: July 11, 2011
    Publication date: November 24, 2011
    Applicants: EMORY UNIVERSITY, U.S. DEPARTMENT OF VETERANS AFFAIRS
    Inventor: Samuel C. Dudley, JR.
  • Modulation of sodium channels by nicotinamide adenine dinucleotide
    Patent number: 8003324
    Abstract: The present invention relates to the use of oxidized nicotinamide adenine dinucleotide (NAD+) or of its reduced form, NADH, as sodium channel modulators. The present invention also relates to the use of compositions containing NAD+ or NADH to treat conditions associated with sodium channel current, such as arrhythmia. NAD+ is found to increase sodium channel current, while NADH is found to decrease sodium channel current. Thus, conditions that are associated with decreased sodium channel current can be treated with NAD+, while conditions that is associated with increased sodium channel current can be treated with NADH.
    Type: Grant
    Filed: October 17, 2008
    Date of Patent: August 23, 2011
    Assignees: U.S. Department of Veterans Affairs, Emory University
    Inventor: Samuel C. Dudley, Jr.
  • Method for modulating or controlling sodium channel current by reactive oxygen species (ROS) originating from mitochondria
    Publication number: 20110144192
    Abstract: Method for modulating or controlling sodium channel current of a cell includes inducing mitochondrial reactive oxygen species (ROS) production in the cell.
    Type: Application
    Filed: February 16, 2011
    Publication date: June 16, 2011
    Applicants: U.S. DEPARTMENT OF VETERANS AFFAIRS, THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
    Inventor: Samuel C. Dudley, JR.
  • MARKER FOR ARRHYTHMIA RISK
    Publication number: 20100233727
    Abstract: The present invention relates to markers and methods for determining risk of ventricular arrhythmia in an African American or woman patient. By using the markers of the present invention, individual with high risk of ventricular arrhythmia can properly be detected and treated. The present inventors have discovered that, in African American and women, IL-6 and/or DROMs and/or CRP have strongly positive correlation with the risk of ventricular arrhythmia.
    Type: Application
    Filed: March 17, 2010
    Publication date: September 16, 2010
    Inventors: Samuel C. DUDLEY, JR., Heather L. BLOOM
  • Method for predicting onset/risk of atrial fibrillation (AF)
    Patent number: 7550299
    Abstract: A method for predicting onset or risk of atrial fibrillation in a subject includes determining the presence of an oxidative stress marker, such as glutathione, cysteine, and/or a derivative of a reactive oxidative metabolite (DROM).
    Type: Grant
    Filed: August 3, 2007
    Date of Patent: June 23, 2009
    Assignees: The United States of America as represented by the Department of Veterans Affairs, Emory University
    Inventors: Samuel C. Dudley, Jr., Dean P. Jones
  • Modulation of sodium channels by nicotinamide adenine dinucleotide
    Publication number: 20090105181
    Abstract: The present invention relates to the use of oxidized nicotinamide adenine dinucleotide (NAD+) or of its reduced form, NADH, as sodium channel modulators. The present invention also relates to the use of compositions containing NAD+ or NADH to treat conditions associated with sodium channel current, such as arrhythmia. NAD+ is found to increase sodium channel current, while NADH is found to decrease sodium channel current. Thus, conditions that are associated with decreased sodium channel current can be treated with NAD+, while conditions that is associated with increased sodium channel current can be treated with NADH.
    Type: Application
    Filed: October 17, 2008
    Publication date: April 23, 2009
    Applicant: The U.S.A Dept. of Veterans Affairs Technology Transfer Program Office of Research & Development
    Inventor: Samuel C. Dudley, JR.
  • MARKER FOR ARRHYTHMIA RISK
    Publication number: 20090092998
    Abstract: The present invention relates to markers and methods for determining risk of ventricular arrhythmia in an individual. By using the markers of the present invention, individual with high risk of ventricular arrhythmia can properly be detected and treated. The present inventors have discovered that IL-6 and/or DROMs have strongly positive correlation with the risk of ventricular arrhythmia.
    Type: Application
    Filed: September 10, 2008
    Publication date: April 9, 2009
    Applicant: The United States of America Department of Veterans Affairs
    Inventor: Samuel C. Dudley, JR.