Patents by Inventor Samuel C. Mok

Samuel C. Mok has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Microfibrillar-Associated Protein 5 (MFAP5)-Targeting Monoclonal Antibodies and Methods for Use in Treating Cancer
    Publication number: 20240199735
    Abstract: Disclosed are antibody compositions and methods for treatment mammalian cancers. Also disclosed are methods for use of the disclosed MFAP5-specific monoclonal antibodies and antigen-binding-fragments thereof, in the treatment, prophylaxis, and/or the amelioration of one or more symptoms of mammalian cancer, including human ovarian and pancreatic cancers, in particular.
    Type: Application
    Filed: July 22, 2020
    Publication date: June 20, 2024
    Inventors: Stephen T.C. WONG, Jianting SHENG, Samuel C. MOK, Cecilia S. LEUNG, Tsz-Lun YEUNG
  • Eosinophil-derived neurotoxin as a marker for ovarian cancer
    Patent number: 7288383
    Abstract: The present invention is directed to methods of identifying women at increased risk of having ovarian cancer. Identification is based upon the extent to which biological samples derived from the women exhibit elevated levels of eosinophil-derived neurotoxin (EDN).
    Type: Grant
    Filed: January 13, 2004
    Date of Patent: October 30, 2007
    Assignee: The Brigham and Women's Hospital, Inc.
    Inventors: Bin Ye, Daniel W. Cramer, Samuel C. Mok
  • Methods of detecting cancer based on osteopontin
    Patent number: 7214501
    Abstract: The present invention is directed to diagnostic methods based upon the expression of the protein prostasin. In particular, it is concerned with assays performed on women to determine their risk of ovarian cancer.
    Type: Grant
    Filed: December 21, 2004
    Date of Patent: May 8, 2007
    Assignees: The Brigham and Women's Hospital, Inc., Battelle Memorial Institute
    Inventors: Samuel C. Mok, Kwong-Kwok Wong
  • Detection of ovarian cancer based upon alpha-haptoglobin levels
    Patent number: 7112408
    Abstract: The present invention is directed to a method for determining whether a woman has, or is likely to develop, ovarian cancer based upon assays of the alpha subunit of haptoglobin.
    Type: Grant
    Filed: June 5, 2002
    Date of Patent: September 26, 2006
    Assignee: The Brigham and Women's Hospital, Inc.
    Inventors: Bin Ye, Samuel C. Mok, Daniel W. Cramer, Ross S. Berkowitz, Steven Skates
  • Methods of detecting cancer based on prostasin
    Patent number: 6846642
    Abstract: The present invention is directed to diagnostic methods based upon the expression of the protein prostasin. In particular, it is concerned with assays performed on women to determine their risk of ovarian cancer.
    Type: Grant
    Filed: September 7, 2001
    Date of Patent: January 25, 2005
    Assignees: The Brigham and Women's Hospital, Inc., Battelle Memorial Institute
    Inventors: Samuel C. Mok, Kwong-Kwok Wong
  • Eosinophil-derived neurotoxin as a marker for ovarian cancer
    Publication number: 20040157251
    Abstract: The present invention is directed to methods of identifying women at increased risk of having ovarian cancer. Identification is based upon the extent to which biological samples derived from the women exhibit elevated levels of eosinophil-derived neurotoxin (EDN).
    Type: Application
    Filed: January 13, 2004
    Publication date: August 12, 2004
    Applicant: The Brigham and Women's Hospital, Inc.
    Inventors: Bin Ye, Daniel W. Cramer, Samuel C. Mok
  • Detection of ovarian cancer based upon alpha-haptoglobin levels
    Publication number: 20030017515
    Abstract: The present invention is directed to a method for determining whether a woman has, or is likely to develop, ovarian cancer based upon assays of the alpha subunit of haptoglobin.
    Type: Application
    Filed: June 5, 2002
    Publication date: January 23, 2003
    Applicant: The Brigham and Women's Hospital, Inc.
    Inventors: Bin Ye, Samuel C. Mok, Daniel W. Cramer, Ross S. Berkowitz, Steven Skates
  • Diagnosing and treating cancer cells using Sal2
    Publication number: 20020156039
    Abstract: The invention features the use of Sal2 nucleic acids and proteins in methods for treating patients having proliferative disorders, such as cancers, involving mutations in a Sal2 nucleic acid sequence and in the protein that it encodes. In addition, these treatment methods may also be used for patients having a mutation in a nucleic acid sequence encoding a protein that interacts with Sal2 or that functions in a signaling pathway involving Sal2. Furthermore, Sal2 may be used as an anti-viral agent that interferes with the ability of a DNA tumor virus to replicate and disseminate in a cell.
    Type: Application
    Filed: November 16, 2001
    Publication date: October 24, 2002
    Inventors: Thomas L. Benjamin, Dawei Li, Samuel C. Mok, Daniel W. Cramer, Yupo Ma
  • Diagnosing and treating cancer cells using Sal2
    Publication number: 20020147996
    Abstract: The invention features the analysis of Sal2 nucleic acids and proteins for diagnosing and treating patients having proliferative disorders, including cancer, involving mutations in a Sal2 gene and encoded protein. The invention also includes transgenic and knockout mice including Sal2 nucleic acids or proteins and mutants thereof. Furthermore, the invention features a method of killing cells carrying a Sal2 alteration using a T-HR mutant.
    Type: Application
    Filed: March 19, 2001
    Publication date: October 10, 2002
    Inventors: Thomas L. Benjamin, Dawei Li, Samuel C. Mok, Daniel W. Cramer, Yupo Ma
  • Methods of detecting cancer based on prostasin
    Publication number: 20020090625
    Abstract: The present invention is directed to diagnostic methods based upon the expression of the protein prostasin. In particular, it is concerned with assays performed on women to determine their risk of ovarian cancer.
    Type: Application
    Filed: September 7, 2001
    Publication date: July 11, 2002
    Applicant: The Brigham and Women's Hospital, Inc.
    Inventors: Samuel C. Mok, Kwong-Kwok Wong