Abstract: Disclosed herein are high affinity anti-Siglec 15 antibodies and methods of using such for therapeutic and/or diagnostic purposes. Also provided herein are methods for producing such anti-Siglec 15 antibodies.

Abstract: Provided herein are engineered IL2 polypeptides and fusion proteins thereof. Also provided are methods of modulating an immune response by administering an engineered IL2 polypeptide or a fusion protein thereof. The engineered IL2 polypeptides and fusion proteins thereof demonstrate increased binding to IL2R?, decreased binding to IL2R?, or both.

Abstract: A system and related techniques and data structures present a Web based or other client application or service with a relational node structure to access, store and manipulate XML-based or XML-compliant data. Unlike unmodified XML information for instance stored in document object model (DOM) format, the inventive platform may load a relational node structure encapsulating XML-compliant information in an organized structure having pointers to next peer, parent, child and other links to related or unrelated information. Searching, querying and other operations may therefore be made more efficient since an entire tree structure need not be exhaustively traversed to locate desired data, but instead sorted via those relational linkages. Client applications such as Web browsing, email, contacts managers, calendars and others may therefore operate on XML or XML-compliant data without the loading or performance disadvantages which conventional XML platforms may incur.

Abstract: An extensible mechanism for storage and interchange of objects is described herein. According to first aspect of the disclosure, objects having respective class definitions are received. The objects are represented in an interchange format by mapping the class definitions of the objects to corresponding fields defined within the interchange format. According to a second aspect of the disclosure, the objects are loaded into a persistent store by mapping the class definitions of the objects to corresponding fields of the store. According to at least a third aspect of the disclosure, a data structure for a unique identifier element is described, along with processes using the unique identifier element to determine whether to update an existing object in the store, or to create a new object in the store.

Abstract: Matching metadata for sporting events with television program listing data. A global sports format enables the import of sports metadata from various providers. The metadata is interlinked with the television program listing data via configurable match rules or criteria. An enhanced electronic programming guide is created to display, to a user, the interlinked metadata.

Abstract: A system and related techniques and data structures present a Web based or other client application or service with a relational node structure to access, store and manipulate XML-based or XML-compliant data. Unlike unmodified XML information for instance stored in document object model (DOM) format, the inventive platform may load a relational node structure encapsulating XML-compliant information in an organized structure having pointers to next peer, parent, child and other links to related or unrelated information. Searching, querying and other operations may therefore be made more efficient since an entire tree structure need not be exhaustively traversed to locate desired data, but instead sorted via those relational linkages. Client applications such as Web browsing, email, contacts managers, calendars and others may therefore operate on XML or XML-compliant data without the loading or performance disadvantages which conventional XML platforms may incur.