Abstract: An electrical connector includes a front housing and a plurality of contact modules stacked side by side along a rear side of the front housing. Each contact module comprises a housing frame, multiple signal conductors and ground conductors held in the housing frame, and a ground shield coupled to an outer side of the housing frame. The housing frame is formed by a first shell member abutting a second shell member at an interface. At least one of the shell members defines multiple openings that align with the ground conductors held in the housing frame. The ground shield includes ground tabs that extend through the openings and engage the ground conductors to electrically connect the ground shield and the ground conductors. Broad sides of the signal conductors and the ground conductors are oriented orthogonal to the interface between the first and second shell members.

Abstract: An electrical connector includes a housing stack, signal and ground conductors, and an electrically conductive ground bracket. The housing stack comprises a front housing and a rear housing. The front housing defines a mating end of the housing stack, and the rear housing defines a mounting end of the housing stack. The housing stack defines signal cavities and ground cavities that extend continuously through the front housing and the rear housing. The signal conductors and ground conductors are held in the signal cavities and ground cavities, respectively, of the housing stack. The signal conductors are arranged in signal pairs, and the ground conductors are interleaved between the signal pairs. The ground bracket is held in the housing stack between the front housing and the rear housing. The ground bracket engages and is electrically connected to each of the ground conductors to electrically common the ground conductors along a ground plane.

Abstract: An electrical connector includes a housing stack, signal and ground conductors, and an electrically conductive ground bracket. The housing stack comprises a front housing and a rear housing. The front housing defines a mating end of the housing stack, and the rear housing defines a mounting end of the housing stack. The housing stack defines signal cavities and ground cavities that extend continuously through the front housing and the rear housing. The signal conductors and ground conductors are held in the signal cavities and ground cavities, respectively, of the housing stack. The signal conductors are arranged in signal pairs, and the ground conductors are interleaved between the signal pairs. The ground bracket is held in the housing stack between the front housing and the rear housing. The ground bracket engages and is electrically connected to each of the ground conductors to electrically common the ground conductors along a ground plane.

Abstract: An electrical connector includes a plurality of contact modules stacked parallel to each other within a housing. Each contact module includes a pair of wafer sub-assemblies. The wafer sub-assemblies are identical and oriented 180° with respect to each other. Each wafer sub-assembly includes an overmolded leadframe and a conductive shell holding the overmolded leadframe. The overmolded leadframe has a plurality of contacts including intermediate sections extending between mating and mounting ends. The intermediate sections are encased in an overmolded body of the overmolded leadframe. The shell has a pocket at an inner side thereof receiving the overmolded leadframe and the inner sides of the shells face each other. The shell has securing features for securing the shells together and the shell provides electrical shielding for the contacts of the overmolded leadframe.

Abstract: A bispecific antibody format providing ease of isolation is provided, comprising immunoglobulin heavy chain variable domains that are differentially modified in the CH3 domain, wherein the differential modifications are non-immunogenic or substantially non-immunogenic with respect to the CH3 modifications, and at least one of the modifications results in a differential affinity for the bispecific antibody for an affinity reagent such as Protein A, and the bispecific antibody is isolable from a disrupted cell, from medium, or from a mixture of antibodies based on its affinity for Protein A.

Abstract: A genetically modified mouse is provided, wherein the mouse expresses an immunoglobulin light chain repertoire characterized by a limited number of light chain variable domains. Mice are provided that express just one or a few immunoglobulin light chain variable domains from a limited repertoire in their germline. Methods for making bispecific antibodies having universal light chains using mice as described herein, including human light chain variable regions, are provided. Methods for making human variable regions suitable for use in multispecific binding proteins, e.g., bispecific antibodies, and host cells are provided. Bispecific antibodies capable of binding first and second antigens are provided, wherein the first and second antigens are separate epitopes of a single protein or separate epitopes on two different proteins are provided.

Abstract: An electrical connector includes a housing, signal contacts, and ground shields. The housing extends between a front end and a rear end and defines a cavity at the front end. The signal contacts are held by the housing and are arranged in pairs carrying differential signals. The signal contacts have mating ends in the cavity for mating with a mating connector. The ground shields are held by the housing and extend along the signal contacts in the cavity. The ground shields have center walls and side walls surrounding associated pairs of the signal contacts on at least two sides thereof. The ground shields each have a commoning feature extending outward from a corresponding side wall. The commoning feature mechanically engages another ground shield in a group of ground shields to electrically join the ground shields of the group within the cavity.

Abstract: A header assembly of a mezzanine connector system may include a main housing defining signal channels extending through the main housing and ground channels extending into a first surface of the main housing, a plurality of signal modules, and a plurality of ground shields. At least a portion of each of the plurality of signal modules is retained within a respective one of the signal channels. At least a portion of each of the plurality of ground shields is retained within at least one of the ground channels.

Abstract: An electrical connector includes a housing, signal contacts, and ground shields. The housing extends between a front end and a rear end and defines a cavity at the front end. The signal contacts are held by the housing and are arranged in pairs carrying differential signals. The signal contacts have mating ends in the cavity for mating with a mating connector. The ground shields are held by the housing and extend along the signal contacts in the cavity. The ground shields have center walls and side walls surrounding associated pairs of the signal contacts on at least two sides thereof. The ground shields each have a commoning feature extending outward from a corresponding side wall. The commoning feature mechanically engages another ground shield in a group of ground shields to electrically join the ground shields of the group within the cavity.

Abstract: Antibodies, antigen-binding proteins and Fc-fusion proteins that comprise recombinant polypeptides containing a chimeric heavy chain constant region sequence are provided that bind to certain Fc receptors however have reduced effector functions. Methods of making constructs for expression of such chimeric Fc-containing antibodies, antigen-binding proteins and Fc-fusion proteins in cell systems, and methods of producing and isolating the chimeric Fc-containing proteins are provided.

Abstract: The present invention provides VEGF antagonists with improved pharmacokinetic properties. According to certain embodiments, a fusion polypeptide capable of antagonizing VEGF activity is provided comprising a modified extracellular ligand binding domain of a VEGF receptor fused to a multimerizing component.

Abstract: A bispecific antibody format providing ease of isolation is provided, comprising immunoglobulin heavy chain variable domains that are differentially modified in the CH3 domain, wherein the differential modifications are non-immunogenic or substantially non-immunogenic with respect to the CH3 modifications, and at least one of the modifications results in a differential affinity for the bispecific antibody for an affinity reagent such as Protein A, and the bispecific antibody is isolable from a disrupted cell, from medium, or from a mixture of antibodies based on its affinity for Protein A.

Abstract: A header assembly of a mezzanine connector system may include a main housing defining signal channels extending through the main housing and ground channels extending into a first surface of the main housing, a plurality of signal modules, and a plurality of ground shields. At least a portion of each of the plurality of signal modules is retained within a respective one of the signal channels. At least a portion of each of the plurality of ground shields is retained within at least one of the ground channels.

Abstract: An electrical connector includes a contact module having a leadframe and a dielectric frame surrounding the leadframe. The leadframe has signal conductors having transition contacts encased in the dielectric frame. The transition contacts are coplanar such that the transition contacts are arranged within a contact plane of the leadframe. The signal conductors have mating contacts extending from the corresponding transition contacts. Each of the mating contacts have a mating interface configured to be electrically connected to a corresponding mating contact of a mating connector. The mating contacts are arranged in pairs with the corresponding mating interfaces aligned in rows along corresponding row axes. Each of the pairs of mating contacts are arranged in different rows.

Abstract: The inherent human biases related to hiring processes are mediated using automated computer based systems. Computer executed logic is configured to detect and compensate for, for example, cultural, gender, and/or racial biases. Specific applications include, but are not limited to, job descriptions, review of resumes and interviews.

Abstract: A leadframe for a contact module includes signal contacts arranged in pairs carrying differential signals. Each pair of signal contacts includes a first signal contact and a second signal contact. Each signal contact has a mating beam at an end thereof configured to be electrically connected to a corresponding header contact of a header assembly. Each mating beam includes a stem and a branch extending from the stem. A first paddle extends from the stem and a second paddle extends from the branch. In an initial, stamped orientation, the mating beams are stamped such that the mating beams of the first and second signal contacts within the same pair of signal contacts are angled non-parallel to one another.

Abstract: A connector assembly includes a contact module having a conductive holder and a frame assembly held by the conductive holder. The conductive holder includes first and second holder members electrically connected to one another and having a chamber divided into a plurality of channels by first and second tabs. The first tabs have posts extending therefrom and the second tabs having holes receiving the posts with tab segments on opposite sides of the associated holes. Each hole has a bridge extending across the hole between the tab segments that blocks electrical radiation across the hole between the adjacent channels. The frame assembly includes a dielectric frame received in the holder members including a plurality of contacts and frame members supporting the contacts routed through corresponding channels. The first and second tabs are disposed between corresponding frame members and the bridges are disposed between corresponding frame members.

Abstract: The present invention relates generally to a method of providing an on-line assessment of digital content, such as video clips (10), across a network, such as the internet. In general terms the steps involved an this embodiment of the methodology include: 1. presenting a stimulant video clip (10); 2. providing means for rating the video clip in real time, in this example a rating bar (12) and slider (14) driven by a computer peripheral device (not shown); 3. collecting rating data relevant to the viewed video clip such as (10).

Abstract: A patient support apparatus for spinal conditions comprising means 10 for supporting a patient in the kneeling position, means 32 for supporting a patient's torso in a range of inclinations below horizontal in order to cause a mass of the patient's torso to tension the spine, the knee support 10 being a pad 10 supported off the floor to bring the patient's back within comfortable reach of the practitioner, the apparatus having an upright reaction surface 18, against which the patient's feet may push.

Abstract: An electrical connector includes a contact module having a leadframe and a dielectric frame surrounding the leadframe. The leadframe has signal conductors having transition contacts encased in the dielectric frame. The transition contacts are coplanar such that the transition contacts are arranged within a contact plane of the leadframe. The signal conductors have mating contacts extending from the corresponding transition contacts. Each of the mating contacts have a mating interface configured to be electrically connected to a corresponding mating contact of a mating connector. The mating contacts are arranged in pairs with the corresponding mating interfaces aligned in rows along corresponding row axes. Each of the pairs of mating contacts are arranged in different rows.